公开(公告)号：US5100662A

公开(公告)日：1992-03-31

申请号：US422047

申请日：1989-10-16

申请人： Lois E. Bolcsak ,  Lawrence Boni ,  Mircea C. Popescu ,  Paul A. Tremblay

发明人： Lois E. Bolcsak ,  Lawrence Boni ,  Mircea C. Popescu ,  Paul A. Tremblay

IPC分类号： A61K9/127 ,  A61K39/145

CPC分类号： A61K9/1271 ,  A61K39/12 ,  A61K39/145 ,  A61K9/1272 ,  A61K2039/55555 ,  C12N2760/16134 ,  Y10T428/2984

摘要： The present invention relates to novel liposomes and liposome-like structures (vesicles) comprising an amount of a derivatized sterol either alone or in combination with additional liposome-forming lipids.Sterols such as cholesterol or other lipids, to which numerous charged or neutral groups are attached, may be used to prepare liposomes and liposome-like structures such as micelles, reverse micelles and hexagonal phases, suspensions of multilamellar vesicles or small unilamellar vesicles. The novel liposomes of the present invention may be prepared with or without the use of organic solvents. These vesicles may entrap compounds varying in polarity and solubility in water and other solvents. The vesicles of the present invention may function as vaccines after entrapment or association of an immunogen, as adjuvants, either alone or in combination with additional adjuvants, including, for example, Freund's adjuvant (and other oil emulsions), Bortedella Pertussis, aluminum salts and other metal salts and Mycobacterial products (including muramyldipeptides), among others. The present invention relates to novel liposomes and liposome-like structures (vesicles) comprising an amount of a derivatized sterol either alone or in combination with additional liposome-forming lipids.

摘要翻译： 本发明涉及包含一定量的衍生化甾醇的新型脂质体和脂质体样结构（囊泡），其单独或与另外的形成脂质体的脂质组合。 许多带电荷或中性基团连接的胆固醇或其他脂质的甾醇可用于制备脂质体和脂质体样结构如胶束，反胶束和六方相，多层囊泡或小单层囊泡的悬浮液。 本发明的新型脂质体可以在使用或不使用有机溶剂的情况下制备。 这些囊泡可能会捕获在水和其他溶剂中极性和溶解度变化的化合物。 本发明的囊泡可以在作为佐剂截留或结合后单独或与另外的佐剂组合（例如弗氏佐剂（和其它油乳剂），百日咳百日咳杆菌，铝盐和 其他金属盐和分枝杆菌产品（包括胞壁酰二肽）等。 本发明涉及包含一定量的衍生化甾醇的新型脂质体和脂质体样结构（囊泡），其单独或与另外的形成脂质体的脂质组合。