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11.发明授权5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof 失效5-烷基或羟烷基取代的-10,11-二氢-5H-二苯并[a，d]环庚烯-5,10-亚胺及其抗惊厥剂
公开(公告)号：US4399141A
公开(公告)日：1983-08-16
申请号：US272864
申请日：1981-06-12
申请人： Paul Anderson , Marcia E. Christy , Ben E. Evans
发明人： Paul Anderson , Marcia E. Christy , Ben E. Evans
IPC分类号： C07C45/56 , C07D295/096 , C07D295/116 , C07D451/02 , A61K31/435 , C07D455/00
CPC分类号： C07D295/096 , C07C45/56 , C07D295/116 , C07D451/02
摘要： 5-Substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anticonvulsants.
摘要翻译： 5-取代的10,11-二氢-5H-二苯并[a，d]环庚烯-5,10-亚胺，其衍生物和药学上可接受的盐可用作抗惊厥药。
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公开(公告)号：US4329465A
公开(公告)日：1982-05-11
申请号：US80896
申请日：1979-10-01
IPC分类号： A61K31/435 , A61K31/55 , A61P21/02 , A61P25/20 , A61P25/26 , A61P43/00 , C07C1/24 , C07C29/143 , C07C29/17 , C07C29/40 , C07C35/37 , C07C45/00 , C07C45/62 , C07C45/67 , C07C45/68 , C07C49/665 , C07C49/683 , C07C49/697 , C07D317/72 , C07D451/14 , C07D487/08 , C07D221/18 , A61K31/47
CPC分类号： C07D451/14 , C07C1/24 , C07C29/143 , C07C29/17 , C07C29/40 , C07C35/37 , C07C45/00 , C07C45/62 , C07C45/673 , C07C45/68 , C07C49/665 , C07C49/683 , C07C49/697 , C07D317/72 , C07D487/08 , C07C2103/04 , C07C2103/36
摘要： Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anxiolytics, antidepressants, anticonvulsants, muscle relaxants and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease.
摘要翻译： 二苯并[a，d]环辛-5,12-（和6,12） - 亚胺，其衍生物和药学上可接受的盐可用作抗焦虑剂，抗抑郁药，抗惊厥药，肌肉松弛剂和治疗混合焦虑抑郁症，最小脑 功能障碍和锥体外系疾病如帕金森病。
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公开(公告)号：US4064139A
公开(公告)日：1977-12-20
申请号：US736672
申请日：1976-10-28
IPC分类号： C07D471/18 , C07D487/08 , C07D487/04
CPC分类号： C07D471/18 , C07D487/08 , Y10S514/906 , Y10S514/964
摘要： Substituted 9,10-dihydroanthracen-9,10-imines are disclosed to be minor tranquilizers, anticonvulsnts, muscle relaxants, and to be useful in the treatment of extrapyramidal disorders such as Parkinson's disease; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions.
摘要翻译： 公开了取代的9,10-二氢蒽-9,10-亚胺是小的镇静剂，抗惊厥药，肌肉松弛剂，并且可用于治疗锥体外系疾病如帕金森病; 还公开了制备这些化合物的方法; 包含这些化合物的药物组合物; 和治疗方法，包括施用这样的化合物和组合物。
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公开(公告)号：US4052508A
公开(公告)日：1977-10-04
申请号：US564012
申请日：1975-04-07
IPC分类号： C07D471/18 , C07D471/08 , A61K31/395 , C07D487/08
CPC分类号： C07D471/18 , Y10S514/906
摘要： Heterocyclic dihydroanthracen imines are disclosed to be useful as minor tranquilizers, anticonvulsants, muscle relaxants and to be useful in the treatment of extrapyramidal disorders such as Parkinson's disease; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions.
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公开(公告)号：US3978127A
公开(公告)日：1976-08-31
申请号：US470500
申请日：1974-05-16
IPC分类号： C07C17/00 , C07C17/14 , C07C17/16 , C07C17/18 , C07C25/18 , C07C45/00 , C07C45/28 , C07C45/29 , C07C45/51 , C07C45/52 , C07C45/63 , C07C45/64 , C07C45/78 , C07C49/807 , C07C49/84 , C07C63/70 , C07D209/48 , C07D233/20 , C07C87/28
CPC分类号： C07D233/20 , C07C17/18 , C07C17/392 , C07C25/18 , C07C45/004 , C07C45/28 , C07C45/29 , C07C45/51 , C07C45/52 , C07C45/63 , C07C45/64 , C07C45/78 , C07D209/48
摘要： New fluoro derivatives of aralkylamine compounds, particularly 2-(2-phenyl-1,1,2,2-tetrafluoroethyl)benzylamine, as well as the N-alkyl and the N,N-dialkyl derivatives thereof are prepared by reaction of 2-bromobenzonitrile with benzylmagnesium chloride to produce 2'-bromo-2-phenylacetophenone; oxidation of said acetophenone with selenous acid to produce 2-bromobenzil; conversion of the benzil compound by treatment with sulfur tetrafluoride to the corresponding 2-bromo-.alpha. ,.alpha.-.alpha.',.alpha.'-tetrafluorobibenzyl; followed by reaction of the 2-bromobibenzyl compound with a metal cyanide to produce the corresponding 2-(2-phenyl-1,1,2,2-tetrafluoroethyl)benzonitrile. This nitrile compound is then reduced with lithium aluminum hydride to produce the corresponding benzylamine, which is then converted, if desired, to the N-alkyl and/or N,N-dialkyl 2-(2-phenyl-1,1,2,2-tetrafluoroethyl)benzylamine. Alternatively, the nitrile or the precursor bromobibenzyl can be converted by Grignard reactions to the corresponding .alpha.-alkyl or .alpha.,.alpha.-dialkylbenzylamine which can then be converted if desired to the corresponding N-alkyl and/or N,N-dialkyl substituted benzylamine compound. The phenyltetrafluoroethylbenzylamine as well as its N-alkyl and N,N-dialkyl derivatives are active as antiarrhythmic agents.
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