公开(公告)号：US20080154088A1

公开(公告)日：2008-06-26

申请号：US12045875

申请日：2008-03-11

Applicant: Mark E. Anderson ,  Donald E. Anderson

Inventor： Mark E. Anderson ,  Donald E. Anderson

IPC: A61B17/43 ,  A61M25/00

CPC classification number: A61D19/027

Abstract: A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.

Abstract translation: 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。

公开(公告)号：US06662750B2

公开(公告)日：2003-12-16

申请号：US10304524

申请日：2002-11-26

Applicant: Mark E. Anderson ,  Donald E. Anderson

Inventor： Mark E. Anderson ,  Donald E. Anderson

IPC: A01K2900

CPC classification number: A61D19/027 ,  Y10S604/906

Abstract: A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.

Abstract translation: 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。

公开(公告)号：USD363676S

公开(公告)日：1995-10-31

申请号：US14821

申请日：1993-10-29

Applicant: Mark E. Anderson ,  Richard J. Cooper ,  Ernie R. Paoli ,  Robert D. Stream

Designer： Mark E. Anderson ,  Richard J. Cooper ,  Ernie R. Paoli ,  Robert D. Stream

公开(公告)号：US20100226929A1

公开(公告)日：2010-09-09

申请号：US12430644

申请日：2009-04-27

Applicant: Mark E. Anderson ,  Peter J. Mohler ,  Douglas R. Spitz, JR. ,  Jeffrey Robert Erickson

Inventor： Mark E. Anderson ,  Peter J. Mohler ,  Douglas R. Spitz, JR. ,  Jeffrey Robert Erickson

IPC: A61K39/395 ,  C07K16/40 ,  C07K17/00 ,  C12N9/12 ,  C12N5/10 ,  G01N33/573 ,  A61P9/00

CPC classification number: C07K16/40 ,  C07K16/44 ,  G01N33/57484 ,  G01N2800/26 ,  G01N2800/2821 ,  G01N2800/32

Abstract: Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.

Abstract translation: 已经发现钙/钙调素依赖性蛋白激酶II（CaMKII）被直接氧化，并观察到CaMKII的直接氧化导致CaMKII的钙独立活化。 产生与氧化形式的CaMKII（oxCaMKII）特异性结合的抗体，并用于检测血液中的oxCaMKII：（1）具有癌症的小鼠; （2）敲除编码甲硫氨酸亚砜还原酶的基因的小鼠; （3）注射血管紧张素II的小鼠; （4）注射细菌内毒素的小鼠; （5）饲喂促氧化（酮生成）饮食的小鼠; 和（6）已经用实验治疗的癌症小鼠。

公开(公告)号：US07549485B2

公开(公告)日：2009-06-23

申请号：US10999811

申请日：2004-11-30

Applicant: Steven R. Radford ,  Kelly D. Ireland ,  Robert A. Laing ,  Daryl L. Pritchard ,  James L. Overstreet ,  Greg W. Presley ,  Scott S. Shu ,  Mark E. Anderson ,  Mathias Mueller

Inventor： Steven R. Radford ,  Kelly D. Ireland ,  Robert A. Laing ,  Daryl L. Pritchard ,  James L. Overstreet ,  Greg W. Presley ,  Scott S. Shu ,  Mark E. Anderson ,  Mathias Mueller

IPC: E21B10/32

CPC classification number: E21B10/322 ,  E21B4/00 ,  E21B4/04 ,  E21B7/00 ,  E21B10/32 ,  E21B17/1014 ,  E21B34/14 ,  E21B44/005 ,  E21B47/18 ,  E21B2034/007

Abstract: An expandable reamer apparatus and methods for reaming a borehole are disclosed, including at least one laterally movable blade carried by a tubular body selectively positioned at an inward position and an expanded position. The at least one laterally movable blade, held inwardly by at least one blade-biasing element, may be forced outwardly by drilling fluid selectively allowed to communicate therewith or by at least one intermediate piston element. For example, an actuation sleeve may allow communication of drilling fluid with the at least one laterally movable blade in response to an actuation device being deployed within the drilling fluid. Alternatively, a chamber in communication with an intermediate piston element in structural communication with the at least one laterally movable blade may be pressurized by way of a movable sleeve, a downhole turbine, or a pump.

Abstract translation: 公开了一种用于铰孔钻孔的可扩展铰刀装置和方法，包括至少一个横向可移动的刀片，其由选择性地定位在向内位置和扩张位置的管状体承载。 通过至少一个叶片偏置元件保持的至少一个可横向移动的叶片可以被选择性地允许与其连通的钻井液或通过至少一个中间活塞元件而被向外施力。 例如，致动套筒可以允许钻井流体与至少一个横向可移动刀片的响应于致动装置部署在钻井流体内。 或者，与中间活塞元件连通的与所述至少一个横向可动叶片结构连通的室可以通过可移动套筒，井下涡轮机或泵来加压。

公开(公告)号：US07343875B2

公开(公告)日：2008-03-18

申请号：US10693660

申请日：2003-10-24

Applicant: Mark E. Anderson ,  Donald E. Anderson

Inventor： Mark E. Anderson ,  Donald E. Anderson

IPC: A01K29/00

CPC classification number: A61D19/027 ,  Y10S604/906

Abstract: A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.

Abstract translation: 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。

公开(公告)号：US06883623B2

公开(公告)日：2005-04-26

申请号：US10268595

申请日：2002-10-09

Applicant: Ronny D. McCormick ,  Mumtaz Ball ,  Mark E. Anderson ,  Mark W. Dykstra ,  Michael L. Doster ,  Matthew R. Isbell

Inventor： Ronny D. McCormick ,  Mumtaz Ball ,  Mark E. Anderson ,  Mark W. Dykstra ,  Michael L. Doster ,  Matthew R. Isbell

IPC: E21B10/46 ,  E21B10/54 ,  E21B10/55 ,  E21B17/10

CPC classification number: E21B10/55 ,  E21B10/46 ,  E21B17/1092

Abstract: A rotary drill bit for drilling subterranean formations configured with at least one protective structure proximate to the rotationally leading and trailing edges of a gage trimmer, wherein the at least one protective structure is positioned at substantially the same exposure as its associated gage trimmer. Particularly, the apparatus of the present invention may provide protection for gage trimmers during drilling, tripping, and/or rotation within a casing; i.e., when changing a drilling fluid. Protective structures may be configured and located according to anticipated drilling conditions including helix angles. In addition, a protective structure may be proximate to more than one gage trimmer while having a substantially equal exposure to each associated gage trimmer. Methods of use and a method of rotary bit design are also disclosed.

Abstract translation: 一种用于钻探地下结构的旋转钻头，其配置有靠近量规修剪器的旋转前缘和后缘的至少一个保护结构，其中所述至少一个保护结构定位在与其相关联的量具修剪器基本相同的曝光处。 特别地，本发明的装置可以在套管内的钻孔，脱扣和/或旋转期间提供对量规修剪器的保护; 即，当改变钻井液时。 可以根据包括螺旋角度的预期钻井条件来构造和定位保护结构。 此外，保护结构可以接近多于一个量具修剪器，同时具有与每个相关联的量具修剪器基本相等的曝光。 还公开了使用方法和旋转钻头设计的方法。

公开(公告)号：US06526917B1

公开(公告)日：2003-03-04

申请号：US10161575

申请日：2002-05-31

Applicant: Mark E. Anderson ,  Donald E. Anderson

Inventor： Mark E. Anderson ,  Donald E. Anderson

IPC: A01K2900

CPC classification number: A61D19/027 ,  Y10S604/906

Abstract: A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.

公开(公告)号：USD336444S

公开(公告)日：1993-06-15

申请号：US482687

申请日：1990-02-21

Applicant: Mark E. Anderson ,  Richard J. Cooper ,  Robert D. Stream

Designer： Mark E. Anderson ,  Richard J. Cooper ,  Robert D. Stream

公开(公告)号：US4832686A

公开(公告)日：1989-05-23

申请号：US878026

申请日：1986-06-24

Applicant: Mark E. Anderson

Inventor： Mark E. Anderson

IPC: A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K9/50 ,  A61K38/20

CPC classification number: A61K9/1647 ,  A61K38/2013 ,  A61K9/204 ,  A61K9/5031 ,  Y10S514/885 ,  Y10S514/965

Abstract: A biocompatible, biodegradable, bioerodible composite polymer matrix comprising interleukin-2 in an appropriate polymer. The polymer may be a polymer or copolymer of lactic acid, lactide, glycolide, glutamic acid, or it may be collagen or albumin. The material contains from 10.sup.2 to 10.sup.8 U IL-2/g of polymer. Also disclosed is a method for making the composite polyer matrix and a method for implanting the material. A soft, malleable controlled-release composite material may be used for intracranial or other implantation and may be shaped or molded to fit the site from which malignant tissue has been removed, opposing the residual tumor, complementing hemostasis, compatible with anatomical structure, and functioning as an implantable immunotherapeutic adjuvant.