摘要:
The present invention relates to adenosine A3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and theirs salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.
摘要:
The present invention relates to substituted pyrimidine compounds of formula I useful as orexin receptor antagonists. The invention also relates to pharmaceutical compositions containing said compounds.
摘要:
A method for producing a cast-iron cylinder liner for piston engines in which a metal chill mold (1) is used which has a tubular mold cavity (2) lined with a layer of a hardening molding material or green sand (3). The melt (7) is introduced into the mold cavity from above in such a manner that the cooling effect from the chill mold and the lining provides a frontage of solidification directed upwardly from the bottom.
摘要:
A grinding machine, particularly designed for machining a chipbreaker groove into the cutting edge of a cutting tool, the grinding machine has a support base and an abrasion wheel mounted to the support base, a workpiece table with anchoring fasteners for securing a workpiece to the table; a pedestal fixed to the support base with a pivot block connected to the pedestal by a vertical adjustment mechanism, the pivot block having a cooperating slide and pivot mechanism connecting the pivot block to the work-piece table for pivoting the table about a horizontal axis and sliding the table along the same horizontal axis; stop devices for delimiting the degree of pivot and length of slide of the work-piece table; and, guage indicators for defining the degree of pivot height and slide length of the work table.
摘要:
New compounds and a process for making the same, for use in inhibiting aggregation in human blood and inhibiting the growth of tumors, said compounds being of the general formula: ##STR1## wherein R is hydrogen, alkanoyl, substituted alkanoyl, aralkanoyl or aroyl and represents .alpha. or .beta. steric position or .alpha. and .beta. position, with the provision that if R stands for p-phenyl-benzoyl then methoxy in the position 2 may stand only in .alpha. or only in .beta. steric position.
摘要:
A mold closing unit for an injection molding machine having a double acting mold closing piston, a closable valve interconnecting both sides of the piston, an auxiliary piston, and a piston rod for each piston, each connecting one side of the pistons to the movable mold part wherein the cylinder spaces on mold closing side of the two pistons are permanently communicated whereby the change in volume of the combined working space is proportional to the areas of the piston rods. The cylinder for the auxiliary piston is placed laterally of the main cylinder so that the overall length of the machine is held to a minimum. An additional return piston is also provided.
摘要:
The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.