公开(公告)号：US07915256B2

公开(公告)日：2011-03-29

申请号：US12399979

申请日：2009-03-08

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

IPC分类号： C07D403/12 ,  A61K31/506

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。

公开(公告)号：US20100240666A1

公开(公告)日：2010-09-23

申请号：US12753383

申请日：2010-04-02

申请人： Martin James Inglis ANDREWS ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Grégory Louis Joseph Bar

发明人： Martin James Inglis ANDREWS ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Grégory Louis Joseph Bar

IPC分类号： A61K31/4985 ,  C07D471/04 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: with Z, R1, R2, R8 and R9 as defined in the written description. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

摘要翻译： 公开了具有由以下表示的式的新型稠合吡嗪化合物：如书面描述中所定义的Z，R 1，R 2，R 8和R 9。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例，炎症，类风湿性关节炎等。

公开(公告)号：US07501411B2

公开(公告)日：2009-03-10

申请号：US11809294

申请日：2007-05-30

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。

公开(公告)号：US08178530B2

公开(公告)日：2012-05-15

申请号：US12970632

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

公开(公告)号：US08173656B2

公开(公告)日：2012-05-08

申请号：US12970659

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

摘要翻译： 公开了具有下列表示的式的新型咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的多种病症， 包括作为非限制性实例的关节炎，炎症等。

公开(公告)号：US20110178067A1

公开(公告)日：2011-07-21

申请号：US12987129

申请日：2011-01-09

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus Macleod

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus Macleod

IPC分类号： A61K31/551 ,  C07D487/04 ,  A61K31/4985 ,  C07D413/14 ,  A61K31/5377 ,  A61P29/00 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。

公开(公告)号：US20110092497A1

公开(公告)日：2011-04-21

申请号：US12970632

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/5377 ,  A61K31/4985 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

公开(公告)号：US07977352B2

公开(公告)日：2011-07-12

申请号：US11998817

申请日：2007-11-30

申请人： Paul John Edwards ,  Wolfgang Schmidt ,  Veronique Birault ,  Friedrich Erich Karl Kroll ,  Andrew Burritt ,  Xueliang Tao ,  Martin James Inglis Andrews ,  Sébastien Laurent Xavier Martina

发明人： Paul John Edwards ,  Wolfgang Schmidt ,  Veronique Birault ,  Friedrich Erich Karl Kroll ,  Andrew Burritt ,  Xueliang Tao ,  Martin James Inglis Andrews ,  Sébastien Laurent Xavier Martina

IPC分类号： A61K31/44

CPC分类号： C07D471/04

摘要： Novel triazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型三唑并吡啶化合物：该化合物可以制备成药物组合物，并可用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例 ，ECM降解，关节降解和/或炎症等。

公开(公告)号：US20090105242A1

公开(公告)日：2009-04-23

申请号：US11998817

申请日：2007-11-30

申请人： Paul John Edwards ,  Wolfgang Schmidt ,  Veronique Birault ,  Friedrich Erich Karl Kroll ,  Andrew Burritt ,  Xueliang Tao ,  Martin James Inglis Andrews ,  Sebastien Laurent Xavier Martina

发明人： Paul John Edwards ,  Wolfgang Schmidt ,  Veronique Birault ,  Friedrich Erich Karl Kroll ,  Andrew Burritt ,  Xueliang Tao ,  Martin James Inglis Andrews ,  Sebastien Laurent Xavier Martina

IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61K31/496

CPC分类号： C07D471/04

摘要： Novel triazolopyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型三唑并吡啶化合物：该化合物可以制备成药物组合物，并可用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例 ，ECM降解，关节降解和/或炎症等。

公开(公告)号：US09354119B2

公开(公告)日：2016-05-31

申请号：US14119501

申请日：2012-05-24

申请人： Wolfgang Schmidt

发明人： Wolfgang Schmidt

IPC分类号： G01J5/08 ,  G01J5/00 ,  F21V23/04 ,  G08B13/19 ,  F21S6/00 ,  F21S8/00 ,  F21S8/04 ,  F21S8/06 ,  F21Y101/02 ,  F21Y105/00

摘要： A radiation sensing device for sensing first radiation (15) comprises a radiation sensor (11) for sensing the first radiation and at least one first radiation guiding member (13) forming at least a part of a first radiation path for guiding, and preferably converging or focusing, the first radiation towards the sensor. The first radiation guiding member (13) also forms at least a part of a second radiation path for guiding second radiation emitted by an illumination device (12). A control circuit (20) comprises a first sensor circuit (21) for operating one or more radiation sensors (11), an illumination circuit (22) for operating one or more illumination devices (22), and at least one connection (26) amongst said circuits (21, 22).