公开(公告)号：US07893058B2

公开(公告)日：2011-02-22

申请号：US11803015

申请日：2007-05-11

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

摘要翻译： 公开了具有下列表示的式的新型咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的多种病症， 包括作为非限制性实例的关节炎，炎症等。

公开(公告)号：US20100298300A1

公开(公告)日：2010-11-25

申请号：US12399979

申请日：2009-03-08

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

IPC分类号： A61K31/551 ,  A61K31/5377 ,  A61K31/519 ,  C07D487/04 ,  C07D243/08 ,  A61P29/00 ,  A61P19/02 ,  A61P9/10 ,  A61P9/00

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。

公开(公告)号：US07915256B2

公开(公告)日：2011-03-29

申请号：US12399979

申请日：2009-03-08

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

IPC分类号： C07D403/12 ,  A61K31/506

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。

公开(公告)号：US07501411B2

公开(公告)日：2009-03-10

申请号：US11809294

申请日：2007-05-30

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus MacLeod

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。

公开(公告)号：US20110218178A1

公开(公告)日：2011-09-08

申请号：US12970659

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： A61K31/635 ,  C07D487/04 ,  A61K31/4985 ,  C07D413/14 ,  A61K31/5377 ,  A61P19/02 ,  A61P29/00

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

摘要翻译： 公开了具有下列表示的式的新型咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的多种病症， 包括作为非限制性实例的关节炎，炎症等。

公开(公告)号：US08178530B2

公开(公告)日：2012-05-15

申请号：US12970632

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus MacLeod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

公开(公告)号：US08173656B2

公开(公告)日：2012-05-08

申请号：US12970659

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/4985

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

摘要翻译： 公开了具有下列表示的式的新型咪唑并[1,2-a]吡嗪化合物：该化合物可以制备为药物组合物，并且可用于预防和治疗包括人在内的哺乳动物中的多种病症， 包括作为非限制性实例的关节炎，炎症等。

公开(公告)号：US20110178067A1

公开(公告)日：2011-07-21

申请号：US12987129

申请日：2011-01-09

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus Macleod

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Juha Andrew Clase ,  Gregory Bar ,  Kim Louise Hirst ,  Angus Macleod

IPC分类号： A61K31/551 ,  C07D487/04 ,  A61K31/4985 ,  C07D413/14 ,  A61K31/5377 ,  A61P29/00 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

摘要翻译： 公开了具有下列化学式的新型[1.2.4]三唑并[1,5-a]吡嗪化合物：该化合物可以制备成药物组合物，并可用于预防和治疗各种病症 在包括人的哺乳动物中，包括作为非限制性实例的疼痛，炎症等。

公开(公告)号：US20110092497A1

公开(公告)日：2011-04-21

申请号：US12970632

申请日：2010-12-16

申请人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

发明人： Martin James Inglis Andrews ,  Paul Edwards ,  Reginald Christophe Xavier Brys ,  Philip Huxley ,  Wolfgang Schmidt ,  Veronique Birault ,  Mark Stuart Chambers ,  Clifford John Harris ,  Angus Macleod ,  Kim Louise Hirst ,  Juha Andrew Clase ,  Gregory Bar

IPC分类号： C07D487/04 ,  A61K31/5377 ,  A61K31/4985 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

公开(公告)号：US08148369B2

公开(公告)日：2012-04-03

申请号：US12151585

申请日：2008-05-07

申请人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

发明人： Martin James Inglis Andrews ,  Mark Stuart Chambers ,  Wolfgang Schmidt ,  Giovanni Alessandro Tricarico ,  Grégory Louis Joseph Bar ,  Kim Louise Hirst ,  Olga Raquel Pinto Santos Oliveira Roussel ,  Juha Andrew Clase

IPC分类号： A61K31/50 ,  A61K31/535 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D487/04

摘要： Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.