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公开(公告)号：US20070010440A1
公开(公告)日：2007-01-11
申请号：US11326924
申请日：2006-01-06
申请人： Jason Schense , John Watson , Isabelle Arrighi
发明人： Jason Schense , John Watson , Isabelle Arrighi
CPC分类号： A61K38/39 , A61K38/1875 , A61K38/29 , A61K38/4833 , A61L27/225 , A61L27/227 , A61L2400/06 , A61L2430/02 , A61K2300/00
摘要： A method of local treatment of specific bone defects such as osteoporosis or bone cysts comprises the step of local administration of a formulation comprising a fusion peptide containing a first domain comprising PTH or BMP 2 or BMP 7, and a second domain comprising a covalently crosslinkable substrate domain; and a material suitable of forming a biodegradable matrix suitable for cellular growth or in-growth, wherein the fusion peptide is covalently linked to the matrix. In one embodiment, the matrix contains one or more contrast agents, and is preferably formed in the absence of a growth factor. The matrix may be used in the treatment of fluid-filled cysts such as Tarlov cysts, ovarian cysts, arachnoid cysts, aneurysmal bone cysts or hepatic cysts.
摘要翻译： 局部治疗特定骨缺损如骨质疏松症或骨囊肿的方法包括局部施用包含含有包含PTH或BMP 2或BMP 7的第一结构域的融合肽的制剂的步骤，以及包含共价可交联底物的第二结构域 域; 以及适于形成适于细胞生长或生长的可生物降解的基质的材料，其中所述融合肽与所述基质共价连接。 在一个实施方案中，基质含有一种或多种造影剂，优选在不存在生长因子的情况下形成。 该基质可用于治疗流体充满囊肿如Tarlov囊肿，卵巢囊肿，蛛网膜囊肿，动脉瘤性骨囊肿或肝囊肿。
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公开(公告)号：US20060148704A1
公开(公告)日：2006-07-06
申请号：US11327214
申请日：2006-01-06
申请人： Jason Schense , John Watson , Isabelle Arrighi
发明人： Jason Schense , John Watson , Isabelle Arrighi
IPC分类号： A61K38/29
CPC分类号： A61K38/29 , A61L27/12 , A61L27/225 , A61L27/227 , A61L27/46 , A61L2430/02 , C07K14/635 , C07K2319/00
摘要： Supplemented matrices comprising a PTH releasably incorporated therein, optionally containing a granular material, are described herein. The PTH is incorporated either through covalent linkage to the matrix or through non-covalent interaction with the matrix and/or the granules. These supplemented matrices decrease the time of healing compared to autograft and or trigger healing of bone fractures which otherwise would not heal. The matrices are biocompatible and biodegradable and can be formed in vitro or in vivo, at the time of implantation. The PTH may be a part of a fusion peptide. PTH can be incorporated into the matrices with full retention of its bioactivity. PTH can be releasably incorporated, using techniques that provide control over how and when and to what degree the PTH is released using the matrix as a controlled release vehicle to heal bone fractures.
摘要翻译： 包含可释放地结合在其中的可选地含有颗粒材料的PTH的补充基质在本文中描述。 通过共价连接到基质中或通过与基质和/或颗粒的非共价相互作用掺入PTH。 与自体移植相比，这些补充的基质减少愈合时间和/或触发骨折的愈合，否则不会愈合。 该基质是生物相容的和可生物降解的并且可以在植入时在体外或体内形成。 PTH可能是融合肽的一部分。 PTH可以并入到具有完全保留其生物活性的基质中。 PTH可以可释放地并入，使用技术来控制使用基质作为受控释放载体来治疗骨折的如何和何时以及在什么程度上释放PTH。
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公开(公告)号：US10589001B2
公开(公告)日：2020-03-17
申请号：US13226618
申请日：2011-09-07
摘要： A pharmaceutical formulation for use in a spinal fusion method, comprising a composition for forming a matrix, a kit comprising the composition, a pharmaceutical product obtainable from the pharmaceutical formulation, and an interbody spinal fusion cage containing the pharmaceutical formulation or the pharmaceutical product are described herein. The composition comprises at least a first matrix material precursor component and a second matrix material precursor component that are able to crosslink to form the matrix under appropriate conditions, a bioactive factor that is biologically active for stimulating bone formation between two vertebrae and for effecting or supporting spinal fusion. The bioactive factor is PTH, optionally a PTH fusion peptide. The bioactive factor is releasably incorporated in the matrix upon crosslinking of the matrix material precursor components.
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14.发明申请Synthetic biomaterials having incorporated therein bioactive factors through enzymatically degradable linkages 审中-公开合成生物材料通过酶可降解的键连接其中的生物活性因子公开(公告)号：US20060147443A1
公开(公告)日：2006-07-06
申请号：US11317846
申请日：2005-12-22
申请人： Jason Schense , Didier Cowling , Matthias Lutolf , Annemie Rehor
发明人： Jason Schense , Didier Cowling , Matthias Lutolf , Annemie Rehor
CPC分类号： A61L27/58 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/29 , A61K38/30 , A61L27/227 , A61L27/54 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/43
摘要： Synthetic biomaterials containing bioactive factors or modified bioactive factors that are covalently bound to the synthetic precursor components and/or biomaterials by an enzymatically degradable linkage are described herein. Further described are methods to covalently bind bioactive factors to synthetic biomaterials by means of enzymatic catalysis, the biomaterials produced therewith and the bioactive factors necessary for practicing these methods. The bioactive factors contain an amino acid sequence which can serve as a substrate domain for cross-linkable enzymes. The enzyme catalyzes the cross-linking reaction between the substrate domain of the bioactive factor and functional groups of the synthetic precursor components capable of forming the biomaterial and/or synthetic biomaterial susceptible to an enzymatically catalyzed cross-linking reaction. The biomaterials described herein may be used for localized delivery of the bioactive factors, for tissue repair and regeneration and in particular for regeneration of soft and hard tissue, such as skin, bone, tendons and cartilage.
摘要翻译： 本文描述了含有生物活性因子或通过可酶促降解的键共价结合于合成前体组分和/或生物材料的修饰的生物活性因子的合成生物材料。 进一步描述的是通过酶催化，由其产生的生物材料和实践这些方法所需的生物活性因子将生物活性因子共价结合到合成生物材料的方法。 生物活性因子含有可用作可交联酶的底物结构域的氨基酸序列。 酶催化生物活性因子的底物结构域和能够形成对酶催化的交联反应敏感的生物材料和/或合成生物材料的合成前体组分的官能团之间的交联反应。 本文所述的生物材料可用于生物活性因子的局部递送，用于组织修复和再生，特别是用于软和硬组织如皮肤，骨骼，腱和软骨的再生。
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公开(公告)号：US08318674B2
公开(公告)日：2012-11-27
申请号：US11326924
申请日：2006-01-06
申请人： Jason Schense , John Watson , Isabelle Arrighi
发明人： Jason Schense , John Watson , Isabelle Arrighi
CPC分类号： A61K38/39 , A61K38/1875 , A61K38/29 , A61K38/4833 , A61L27/225 , A61L27/227 , A61L2400/06 , A61L2430/02 , A61K2300/00
摘要： A method of local treatment of specific bone defects such as osteoporosis or bone cysts comprises the step of local administration of a formulation comprising a fusion peptide containing a first domain comprising PTH or BMP 2 or BMP 7, and a second domain comprising a covalently crosslinkable substrate domain; and a material suitable of forming a biodegradable matrix suitable for cellular growth or in-growth, wherein the fusion peptide is covalently linked to the matrix. In one embodiment, the matrix contains one or more contrast agents, and is preferably formed in the absence of a growth factor. The matrix may be used in the treatment of fluid-filled cysts such as Tarlov cysts, ovarian cysts, arachnoid cysts, aneurysmal bone cysts or hepatic cysts.
摘要翻译： 局部治疗特定骨缺损如骨质疏松症或骨囊肿的方法包括局部施用包含含有包含PTH或BMP 2或BMP 7的第一结构域的融合肽的制剂的步骤，以及包含共价可交联底物的第二结构域 域; 以及适于形成适于细胞生长或生长的可生物降解的基质的材料，其中所述融合肽与所述基质共价连接。 在一个实施方案中，基质含有一种或多种造影剂，优选在不存在生长因子的情况下形成。 该基质可用于治疗流体充满囊肿如Tarlov囊肿，卵巢囊肿，蛛网膜囊肿，动脉瘤性骨囊肿或肝囊肿。
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公开(公告)号：US20110311643A1
公开(公告)日：2011-12-22
申请号：US13167488
申请日：2011-06-23
申请人： Jason Schense , John Watson , Isabelle Arrighi
发明人： Jason Schense , John Watson , Isabelle Arrighi
CPC分类号： A61K38/29 , A61L27/225 , A61L27/427 , A61L27/46 , A61L27/54 , A61L2300/252 , A61L2300/43 , A61L2430/02 , C07K14/635 , C07K2319/00
摘要： Supplemented matrices comprising a PTH releasably incorporated therein, optionally containing a granular material, which are used to heal bone fractures, particularly bone fractures with a risk of becoming delayed unions or non-unions, are described herein. The PTH is incorporated either through covalent linkage to the matrix or through non-covalent interaction with the matrix and/or the granules. These supplemented matrices decrease the time of healing compared to autograft and or trigger healing of bone fractures which otherwise would not heal. The matrices are biocompatible, preferably biodegradable, and can be formed in vitro or in vivo, at the time of implantation. The PTH may be a part of a fusion peptide. PTH can be incorporated into the matrices with full retention of its bioactivity. PTH can be releasably incorporated in the matrix.
摘要翻译： 本文描述了包含可释放地并入其中的PTH的补充基质，任选地含有颗粒材料，其用于治疗骨折，特别是具有变为延迟联合或非联合的风险的骨折。 通过共价连接到基质中或通过与基质和/或颗粒的非共价相互作用掺入PTH。 与自体移植相比，这些补充的基质减少愈合时间和/或触发骨折的愈合，否则不会愈合。 基质是生物相容的，优选可生物降解的，并且可以在植入时在体外或体内形成。 PTH可能是融合肽的一部分。 PTH可以并入到具有完全保留其生物活性的基质中。 PTH可以可释放地并入基质中。
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