公开(公告)号：US20130015367A1

公开(公告)日：2013-01-17

申请号：US13353029

申请日：2012-01-18

Applicant: Meng Cui

Inventor： Meng Cui

IPC: G01J3/45 ,  G01N21/64

CPC classification number: G01B9/02091 ,  A61B5/0062 ,  A61B5/0066 ,  G01J3/45 ,  G01J9/02 ,  G01J9/04 ,  G02B26/06 ,  G02B27/0031

Abstract: An apparatus includes a transverse scanning optical system in the path of a first light beam traveling along a first optic axis; a wavefront correction system in the path of a second light beam traveling along a second optic axis, the wavefront correction system including a wavefront correction device having a spatial phase profile on its surface; a beam combiner that receives the first light beam and the second light beam and outputs an interference beam having a beat frequency equal to a difference frequency between the first light beam and second light beam; and a detection system placed relative to a random scattering medium, which is in the path of the interference beam. The detection system detects measurement light produced by the random scattering medium while the interference beam strikes the random scattering medium.

Abstract translation: 一种装置包括在沿着第一光轴行进的第一光束的路径中的横向扫描光学系统; 所述波前校正系统包括沿着第二光轴行进的第二光束的路径中的波前校正系统，所述波前校正系统包括在其表面上具有空间相位轮廓的波前校正装置; 接收第一光束和第二光束并且输出具有等于第一光束和第二光束之间的差分频率的拍频的干涉光束的光束组合器; 以及相对于在干涉光束的路径中的随机散射介质放置的检测系统。 检测系统检测由随机散射介质产生的测量光，同时干涉光束照射随机散射介质。

公开(公告)号：US20110309267A1

公开(公告)日：2011-12-22

申请号：US13157194

申请日：2011-06-09

Applicant: Meng Cui ,  Changhuei Yang

Inventor： Meng Cui ,  Changhuei Yang

IPC: A61N5/00

CPC classification number: A61N5/00 ,  H05K999/00 ,  H05K999/99

Abstract: A method, apparatus, and article of manufacture for irradiating a sample with electromagnetic (EM) radiation. A number of passes of EM radiation through a sample are formed and/or selected, wherein the EM radiation in each of the passes comprises (1) input EM radiation incident on the sample, and (2) transmitted EM radiation exiting the sample formed from the input EM radiation that is transmitted through the sample. A phase conjugate of the transmitted EM radiation is used as the input EM radiation in a next pass of the EM radiation. The number of passes results in one or more EM fields of the input EM radiation having at least a threshold transmittance through the sample.

Abstract translation: 一种用电磁（EM）辐射照射样品的方法，设备和制品。 形成和/或选择通过样本的EM辐射的多次通过，其中每个通路中的EM辐射包括（1）入射在样品上的输入EM辐射，和（2）离开从 通过样品传输的输入EM辐射。 在EM辐射的下一次通过中，所使用的EM辐射的相位共轭被用作输入EM辐射。 通过次数导致输入EM辐射的一个或多个EM场具有通过样本的至少一个阈值透射率。

公开(公告)号：US20110108707A1

公开(公告)日：2011-05-12

申请号：US12943841

申请日：2010-11-10

Applicant: Meng Cui ,  Ying Min Wang ,  Charles DiMarzio ,  Changhuei Yang

Inventor： Meng Cui ,  Ying Min Wang ,  Charles DiMarzio ,  Changhuei Yang

IPC: H01L27/00 ,  G01N21/64

CPC classification number: G02B21/0056 ,  A61B5/0059 ,  A61B5/0066 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2021/1708 ,  G01N2021/1727 ,  G02B21/00 ,  G02B21/0004 ,  G02B21/0068 ,  G02B21/0092 ,  Y10T29/49826

Abstract: A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic waves frequency shift a frequency of light passing through the focus, thereby creating a frequency shifted light beam; at least one spatial light modulator (SLM) positioned to illuminate the sample with an output beam that is an optical phase conjugate of the frequency shifted light beam, wherein the output beam is a reflection of a first reference beam off one or more pixels of the SLM, and the pixels are for modulating the first reference beam to create the output beam; and a detector positioned to detect fluorescence generated by the output beam exciting the fluorescent agents at the focus in the sample, thereby imaging the sample.

Abstract translation: 一种用于对含有一种或多种荧光剂的样品进行成像的光学显微镜，其包括用于产生聚焦在样品中的聚焦的声波的源，其中所述声波使通过所述焦点的光的频率偏移，由此产生频率 移动光束; 至少一个空间光调制器（SLM），定位成用作为所述频移光束的光学相位共轭的输出光束照射所述样本，其中所述输出光束是第一参考光束的反射离开所述第一参考光束的一个或多个像素 SLM，并且像素用于调制第一参考光束以产生输出光束; 以及检测器，用于检测在样品中焦点处激发荧光剂的输出光束产生的荧光，从而对样品进行成像。