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公开(公告)号：US07412015B2
公开(公告)日：2008-08-12
申请号：US10920510
申请日：2004-08-18
申请人： Jack Nachamkin , Vincent Mancuso
发明人： Jack Nachamkin , Vincent Mancuso
IPC分类号： H03D1/04
CPC分类号： H03D3/006
摘要： Methods and apparatus for separating desired signals from a mixed signal. A preferred method includes identifying the frequencies associated with the independent signals within the mixed signal and sampling the mixed signal once for each of the identified frequencies. Using the identified frequencies, a set of constant coefficients is determined and applied to the samples to separate at least one of the independent signals from the mixed signal. The other independent signals may then be suppressed. A signal processing system is also supplied that includes memory and a circuit. The memory stores samples of the mixed signal for the circuit to process. The circuit identifies the frequencies of the independent signals, determines a set of coefficients, and applies the coefficients to the mixed signal. Thus, the system separates a desired signal from the mixed signal.
摘要翻译： 用于从混合信号中分离所需信号的方法和装置。 优选的方法包括识别与混合信号内的独立信号相关联的频率，并且针对每个识别的频率对混合信号进行一次采样。 使用所识别的频率，确定一组常数系数并将其应用于采样以将独立信号中的至少一个与混合信号分离。 然后可以抑制其他独立信号。 还提供了包括存储器和电路的信号处理系统。 存储器存储用于电路处理的混合信号的采样。 电路识别独立信号的频率，确定一组系数，并将系数应用于混合信号。 因此，系统将期望的信号与混合信号分离。
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公开(公告)号：US06777428B1
公开(公告)日：2004-08-17
申请号：US09890741
申请日：2001-12-04
IPC分类号： C07D21122
CPC分类号： C07D401/06 , C07D211/22 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to a compound of formula I and a process for making: or a pharmaceutical acid addition salt thereof; which are useful for activating 5-HT1F receptors and inhibiting neuronal protein extravasation in a mammal.
摘要翻译： 本发明涉及式I化合物及其制备方法：或其药用酸加成盐; 其可用于激活哺乳动物中的5-HT1F受体并抑制神经元蛋白质外渗。
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公开(公告)号：US20130089573A1
公开(公告)日：2013-04-11
申请号：US13702691
申请日：2011-06-08
CPC分类号： A61K9/1075 , A61K9/0019 , A61K9/107 , A61K39/39 , A61K47/06 , A61K47/22 , A61K2039/55588
摘要： The present invention provides processes for the production of a submicron oil in water emulsion comprising the steps of preparing a submicron oil in water emulsion; pre-filtering the oil in water emulsion through a first sterile grade filter and again filtering the oil in water emulsion through a second sterile grade filter.
摘要翻译： 本发明提供了生产亚微米水包油乳液的方法，包括以下步骤：制备亚微米水包油乳液; 通过第一个无菌级过滤器预过滤水包油乳液，并再次通过第二个无菌级过滤器过滤水中的乳液。
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公开(公告)号：US20130079395A1
公开(公告)日：2013-03-28
申请号：US13702713
申请日：2011-06-08
IPC分类号： A61K9/107 , A61K31/355
CPC分类号： A61K9/1075 , A61K9/0019 , A61K9/107 , A61K31/01 , A61K31/355 , A61K2039/55566
摘要： The present invention provides a process for the production of an oil in water emulsion comprising the step of a) introducing an oil phase into a mixing device by applying a positive pressure in the oil phase containing tank.
摘要翻译： 本发明提供了一种生产水包油乳液的方法，其包括以下步骤：a）通过在含油罐中施加正压将油相引入混合装置。
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公开(公告)号：US6150525A
公开(公告)日：2000-11-21
申请号：US188784
申请日：1998-11-06
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides processes and intermediates of Formula I: ##STR1## where X and R are defined in the specification, for the preparation of 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo-[3,2-b]pyridine.
摘要翻译： 本发明提供式I的方法和中间体：其中X和R在本说明书中定义，用于制备5-氨基-3-（1-甲基哌啶-4-基）吡咯并[3,2-b]吡啶 。
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公开(公告)号：US20140234403A1
公开(公告)日：2014-08-21
申请号：US14346047
申请日：2012-09-19
申请人： Carine De Kesel , Vincent Mancuso
发明人： Carine De Kesel , Vincent Mancuso
CPC分类号： A61K47/24 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K47/28 , A61K47/36 , Y02A50/411
摘要： Provided are compositions and methods for producing a lipidic film. The method comprises the steps of: (i) dissolving a lipid mix in isopropanol to form a homogeneous mix; and (ii) removing the solvent from the homogeneous mix to form a lipidic film, wherein the lipid mix comprises a lipid and cholesterol.
摘要翻译： 提供了用于制备脂质膜的组合物和方法。 该方法包括以下步骤：（i）将脂质混合物溶解在异丙醇中以形成均匀的混合物; 和（ii）从均匀混合物中除去溶剂以形成脂质膜，其中所述脂质混合物包含脂质和胆固醇。
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公开(公告)号：US07314879B2
公开(公告)日：2008-01-01
申请号：US10500476
申请日：2003-01-21
申请人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie
发明人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie
IPC分类号： A61K31/496 , C07D401/12 , C07D405/12 , C07D407/12
CPC分类号： C07D217/26 , C07D209/44 , C07D211/26 , C07D211/96 , C07D295/033 , C07D309/04 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to melanocortin receptor agonist of the formula (I): which is useful in the treatment for obesity, diabetes, and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式（I）的黑皮质素受体激动剂：其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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18.发明授权公开(公告)号：US07186715B2
公开(公告)日：2007-03-06
申请号：US10466248
申请日：2002-01-23
申请人： Karin Briner , Christopher William Doecke , Vincent Mancuso , Michael John Martinelli , Timothy Ivo Richardson , Roger Ryan Rothhaar , Qing Shi , Chaoyu Xie
发明人： Karin Briner , Christopher William Doecke , Vincent Mancuso , Michael John Martinelli , Timothy Ivo Richardson , Roger Ryan Rothhaar , Qing Shi , Chaoyu Xie
IPC分类号： A61K31/496 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
CPC分类号： A61K45/06 , C07D209/44 , C07D217/14 , C07D217/26 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式I的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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19.发明授权公开(公告)号：US07157463B2
公开(公告)日：2007-01-02
申请号：US10466249
申请日：2002-01-23
申请人： Ryan Thomas Backer , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Chaoyu Xie
发明人： Ryan Thomas Backer , Karin Briner , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Chaoyu Xie
IPC分类号： A61K31/496 , C07D401/12 , C07D403/12 , C07D403/14
CPC分类号： C07D401/12 , C07D209/44 , C07D217/26 , C07D401/14
摘要： The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction
摘要翻译： 本发明涉及式I的黑皮质素受体激动剂，其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍
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公开(公告)号：US20060039511A1
公开(公告)日：2006-02-23
申请号：US10920510
申请日：2004-08-18
申请人： Jack Nachamkin , Vincent Mancuso
发明人： Jack Nachamkin , Vincent Mancuso
IPC分类号： H03D1/04
CPC分类号： H03D3/006
摘要： Methods and apparatus for separating desired signals from a mixed signal. A preferred method includes identifying the frequencies associated with the independent signals within the mixed signal and sampling the mixed signal once for each of the identified frequencies. Using the identified frequencies, a set of constant coefficients is determined and applied to the samples to separate at least one of the independent signals from the mixed signal. The other independent signals may then be suppressed. A signal processing system is also supplied that includes memory and a circuit. The memory stores samples of the mixed signal for the circuit to process. The circuit identifies the frequencies of the independent signals, determines a set of coefficients, and applies the coefficients to the mixed signal. Thus, the system separates a desired signal from the mixed signal.
摘要翻译： 用于从混合信号中分离所需信号的方法和装置。 优选的方法包括识别与混合信号内的独立信号相关联的频率，并且针对每个识别的频率对混合信号进行一次采样。 使用所识别的频率，确定一组常数系数并将其应用于采样以将独立信号中的至少一个与混合信号分离。 然后可以抑制其他独立信号。 还提供了包括存储器和电路的信号处理系统。 存储器存储用于电路处理的混合信号的采样。 电路识别独立信号的频率，确定一组系数，并将系数应用于混合信号。 因此，系统将期望的信号与混合信号分离。
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