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公开(公告)号：US20120283221A1
公开(公告)日：2012-11-08
申请号：US13550963
申请日：2012-07-17
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nillsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nillsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , C07F9/40 , C07F9/576 , A61K31/662 , C07F9/6509
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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12.发明申请公开(公告)号：US20090118234A1
公开(公告)日：2009-05-07
申请号：US12288999
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrene de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrene de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , A61P11/06
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及可用作丝氨酸蛋白酶抑制剂的膦酸化合物，其组合物和用于治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US07459461B2
公开(公告)日：2008-12-02
申请号：US10414782
申请日：2003-04-16
申请人： Michael N. Greco , Harold R. Almond , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/4468 , C07F9/30
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及可用作丝氨酸蛋白酶抑制剂的膦酸化合物，其组合物和用于治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US20090118508A1
公开(公告)日：2009-05-07
申请号：US12288941
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donaid Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leoperd Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donaid Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leoperd Sorgi , Eugene Powell
IPC分类号： C07F9/28
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US08609888B2
公开(公告)日：2013-12-17
申请号：US13550963
申请日：2012-07-17
IPC分类号： A61K31/662 , C07F9/28 , C07F9/30
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US08207338B2
公开(公告)日：2012-06-26
申请号：US12973013
申请日：2010-12-20
IPC分类号： C07F9/59 , A61K31/445
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20110319363A1
公开(公告)日：2011-12-29
申请号：US12972848
申请日：2010-12-20
IPC分类号： A61K31/675 , A61K31/662 , A61P29/00 , A61P19/02 , A61P11/08 , A61P17/06 , A61P37/08 , A61P9/10 , C07F9/38 , A61P11/06
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20110092457A1
公开(公告)日：2011-04-21
申请号：US12972891
申请日：2010-12-20
IPC分类号： A61K31/675 , C07F9/58 , C07F9/38 , C07F9/572 , C07F9/6561 , C07F9/6509 , A61K31/662
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US08247599B2
公开(公告)日：2012-08-21
申请号：US12290028
申请日：2008-10-24
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20110092705A1
公开(公告)日：2011-04-21
申请号：US12973013
申请日：2010-12-20
IPC分类号： C07F9/38
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及可用作丝氨酸蛋白酶抑制剂的膦酸化合物，其组合物和用于治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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