利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

77 条记录 (耗时 0.035 秒)

    Stable microbubble suspensions comprising saturated phospholipios for ultrasonic echography
    12.
    发明授权
    Stable microbubble suspensions comprising saturated phospholipios for ultrasonic echography 失效
    稳定的微泡悬浮液，包括用于超声波回波造影的饱和磷脂

    公开(公告)号：US5908610A

    公开(公告)日：1999-06-01

    申请号：US883592

    申请日：1997-06-26

    申请人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    发明人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    IPC分类号： A61K47/24 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61K9/127 ,  A61K49/00 ,  A61K49/22 ,  B01F3/04 ,  B01J13/02

    CPC分类号： A61K49/225 ,  A61K49/223

    摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

    摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

    Stable microbubble suspensions as enhancement agents for ultrasound echography
    15.
    发明授权
    Stable microbubble suspensions as enhancement agents for ultrasound echography 失效
    稳定的微泡悬浮液作为超声波回波成像的增强剂

    公开(公告)号：US5445813A

    公开(公告)日：1995-08-29

    申请号：US134671

    申请日：1993-10-12

    申请人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    发明人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    IPC分类号： A61K47/24 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61K9/127 ,  A61K49/00 ,  A61K49/22 ,  B01F3/04 ,  B01J13/02

    CPC分类号： A61K49/225 ,  A61K49/223

    摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

    摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

    Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography
    17.
    发明授权
    Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography 失效
    稳定的微泡悬浮液，包括用于超声回波的饱和磷脂

    公开(公告)号：US5686060A

    公开(公告)日：1997-11-11

    申请号：US420677

    申请日：1995-04-12

    申请人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    发明人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    IPC分类号： A61K47/24 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61K9/127 ,  A61K49/00 ,  A61K49/22 ,  B01F3/04 ,  B01J13/02

    CPC分类号： A61K49/225 ,  A61K49/223

    摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

    摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

    Stable microbubble suspensions as enhancement agents for ultrasound echography
    18.
    发明授权
    Stable microbubble suspensions as enhancement agents for ultrasound echography 失效
    稳定的微泡悬浮液作为超声波回波成像的增强剂

    公开(公告)号：US5597549A

    公开(公告)日：1997-01-28

    申请号：US414718

    申请日：1995-03-31

    申请人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    发明人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    IPC分类号： A61K47/24 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61K9/127 ,  A61K49/00 ,  A61K49/22 ,  B01F3/04 ,  B01J13/02

    CPC分类号： A61K49/225 ,  A61K49/223

    摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

    摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

    Gas-filled microvesicle assembly for contrast imaging
    19.
    发明授权
    Gas-filled microvesicle assembly for contrast imaging 有权

    公开(公告)号：US09750821B2

    公开(公告)日：2017-09-05

    申请号：US10584327

    申请日：2004-12-21

    申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

    发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

    IPC分类号： A61K47/48 ,  A61K41/00 ,  A61K49/22

    CPC分类号： A61K47/6925 ,  A61K41/0028 ,  A61K49/225

    摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

    Gas-filled microvesicle assembly for contrast imaging
    20.
    发明申请
    Gas-filled microvesicle assembly for contrast imaging 有权
    气体填充微泡组件，用于对比成像

    公开(公告)号：US20070071685A1

    公开(公告)日：2007-03-29

    申请号：US10584327

    申请日：2004-12-21

    申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

    发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

    IPC分类号： A61K49/22

    CPC分类号： A61K47/6925 ,  A61K41/0028 ,  A61K49/225

    摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

    摘要翻译： 组件包括充气微泡和结构实体，其能够通过静电相互作用与所述微囊体（微泡相关组分-MAC）的外表面缔合，从而改变其物理化学性质。 所述MAC可以任选地包含靶向配体，生物活性剂，诊断剂或其任何组合。 本发明的组件可以由气体填充的微泡或微球和直径小于100μm的MAC，特别是胶束形成，并且用作诊断和/或治疗活性制剂中的活性成分，特别是用于增强 在超声对比成像领域的成像，包括靶向超声成像，超声介导的药物递送和其他成像技术如分子共振成像（MRI）或核成像。