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    Method for Forming Nano-bubble
    1.
    发明申请
    Method for Forming Nano-bubble 有权
    形成纳米气泡的方法

    公开(公告)号：US20100080759A1

    公开(公告)日：2010-04-01

    申请号：US12423956

    申请日：2009-04-15

    申请人： Walter H. Chang ,  Cheng-An Lin ,  Chih-Hsien Lee ,  Chih-Kuang Yeh

    发明人： Walter H. Chang ,  Cheng-An Lin ,  Chih-Hsien Lee ,  Chih-Kuang Yeh

    IPC分类号： A61K49/22 ,  A61K47/30 ,  A61K49/18

    CPC分类号： A61K49/223 ,  B82Y5/00 ,  Y10S977/906 ,  Y10S977/929

    摘要： The present invention discloses a method for forming a nano-bubble. The forming method is different from the oil-water emulsion reaction in the prior art. The method comprises: taking an inorganic particle as a nucleus and performing a polymer coating process to coat at least one first polymer on the surface of the nucleus to form an organic/inorganic composite particle; then removing the nucleus of the organic/inorganic composite particle by way of the dissolution of a first solvent to form an impregnated nano-particle; performing a freeze-drying process to remove the first solvent to have the impregnated nano-particle form a hollow nano-particle; and finally dissolving the hollow nano-particle in a second solvent to form the nano-bubble.

    摘要翻译： 本发明公开了一种形成纳米气泡的方法。 成型方法与现有技术中的油水乳液反应不同。 该方法包括：以无机颗粒为核，并进行聚合物涂覆工艺以在核表面上涂覆至少一种第一聚合物以形成有机/无机复合颗粒; 然后通过溶解第一溶剂去除有机/无机复合颗粒的核以形成浸渍的纳米颗粒; 进行冷冻干燥处理以除去第一溶剂以使浸渍的纳米颗粒形成中空纳米颗粒; 最终将中空纳米颗粒溶解在第二溶剂中以形成纳米气泡。

    Contrast agents
    3.
    发明申请
    Contrast agents 审中-公开
    对比剂

    公开(公告)号：US20050118104A1

    公开(公告)日：2005-06-02

    申请号：US10889361

    申请日：2004-07-12

    申请人： Jonny Ostensen ,  Morten Eriksen ,  Sigmund Frigstad ,  Pal Rongved

    发明人： Jonny Ostensen ,  Morten Eriksen ,  Sigmund Frigstad ,  Pal Rongved

    IPC分类号： A61K49/00 ,  A61K9/107 ,  A61K9/127 ,  A61K49/22

    CPC分类号： A61K49/223 ,  Y10S977/928 ,  Y10S977/929

    摘要： Ultrasonic visualisation of a suject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.

    摘要翻译： 使用新型含气体的造影剂制剂进行超声波可视化，特别是心肌和其他组织中的灌注，其可在给药后在体内促进气相的可控和临时生长，因此可用作沉积灌注示踪剂。 制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。 在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。

    Methods for diagnostic imaging by regulating the administration rate of contrast agent
    5.
    发明申请
    Methods for diagnostic imaging by regulating the administration rate of contrast agent 审中-公开
    通过调节造影剂的施用率进行诊断成像的方法

    公开(公告)号：US20030012735A1

    公开(公告)日：2003-01-16

    申请号：US10213533

    申请日：2002-08-06

    发明人： Evan C. Unger ,  Terry Matsunaga ,  Thomas A. Fritz ,  Varadarajan Ramaswami

    IPC分类号： A61K049/00 ,  G06K009/00

    CPC分类号： A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

    摘要： Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

    摘要翻译： 提供患者内部区域的图像的方法。 该方法的实施方案涉及向患者施用造影剂，其包含囊泡组合物，所述囊泡组合物在水性载体中包含气体或气体前体和包含脂质，蛋白质或聚合物的囊泡。 使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。 将造影剂以基本上消除图像中的诊断伪像的速率施用于患者。 该方法对于诊断患者中任何患病组织的存在特别有用。

    CONTRAST AGENTS
    8.
    发明申请
    CONTRAST AGENTS 失效
    对比剂

    公开(公告)号：US20010002993A1

    公开(公告)日：2001-06-07

    申请号：US09291277

    申请日：1999-04-14

    发明人： JONNY OSTENSEN ,  MORTEN ERIKSEN ,  SIGMUND FRIGSTAD ,  PAL RONGVED

    IPC分类号： A61B008/00

    CPC分类号： A61K49/223 ,  Y10S977/928 ,  Y10S977/929

    摘要： Ultrasonic visualisation of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.

    摘要翻译： 使用新型含气体的造影剂制剂，使用受试者的超声波可视化，特别是心肌和其他组织中的灌注进行，其在给药后在体内促进气相的可控和临时生长，因此可用作沉积的灌注示踪剂。 制剂包括可共混组合物，其包含能够向内扩散到分散气相中以促进其暂时生长的可扩散组分。 在心脏灌注成像中，制剂可以有利地与血管扩张剂药物如腺苷共同施用，以分别增强来自正常和低灌注心肌组织的返回信号强度的差异。

    Bioadhesive microspheres and their use as drug delivery and imaging systems
    9.
    发明授权
    Bioadhesive microspheres and their use as drug delivery and imaging systems 失效
    生物粘附微球及其作为药物递送和成像系统的用途

    公开(公告)号：US06217908B1

    公开(公告)日：2001-04-17

    申请号：US08052473

    申请日：1993-04-23

    申请人： Edith Mathiowitz ,  Donald Chickering ,  Jules Serge Jacob

    发明人： Edith Mathiowitz ,  Donald Chickering ,  Jules Serge Jacob

    IPC分类号： A61K916

    CPC分类号： A61K9/1641 ,  A61K9/167 ,  Y10S977/795 ,  Y10S977/906 ,  Y10S977/929

    摘要： Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres all have a bioadhesive force of at least 11 mN/cm2 (110 N/m2). Techniques for the fabrication of bioadhesive microspheres, as well as a method for measuring bioadhesive forces between microspheres and selected segments of the gastrointestinal tract in vitro are also described. This quantitative method provides a means to establish a correlation between the chemical nature, the surface morphology and the dimensions of drug-loaded microspheres on one hand and bioadhesive forces on the other, allowing the screening of the most promising materials from a relatively large group of natural and synthetic polymers which, from theoretical consideration, should be used for making bioadhesive microspheres.

    摘要翻译： 描述了可以用作胃肠道疾病中的治疗或诊断目的的药物或生物活性物质的形式或作为包衣形式的生物粘附聚合物。 聚合物微球全部具有至少11mN / cm 2（110N / m 2）的生物附着力。 还描述了用于制造生物粘附微球的技术，以及用于测量体外微球和胃肠道的选定区段之间的生物粘附力的方法。 这种定量方法提供了一种手段来建立化学性质，表面形态和药物负载微球的尺寸与生物粘附力之间的相关性，另一方面可以从相对较大的组中筛选出最有希望的材料 天然和合成的聚合物，从理论上考虑，应用于制造生物粘附微球。