摘要:
Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The spiro derivative according to the present invention has the chemical structure, for example, represented by the following Formula (31):
摘要:
Novel tricyclic triazolo derivatives and pharmaceutically acceptable salts thereof, which are useful as anti-inflammation agents, anti-allergy agents or anti-PAF agents as well as processes for producing the same are disclosed. The triazolo derivatives of the present invention are represented by the formula (I): ##STR1## �wherein R.sup.1 represents hydrogen, lower alkyl or C.sub.3 -C.sub.5 cycloalkyl; R.sup.2 and R.sup.3 respectively represent hydrogen, lower alkyl, lower alkoxy or halogen; W represents C.dbd.O or CR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 respectively represents hydrogen or lower alkyl); A represents C.sub.1 -C.sub.5 straight or branched saturated or unsaturated alkylene which may contain one or more hetero atoms; l represents 0 to 2, n represents 1 to 3, . . . represents single bond or double bond; Y represents N or C; Z represents C(B)Ar.sup.1 Ar.sup.2 (wherein B represents hydrogen, hydroxy or methoxy, Ar.sup.1 and Ar.sup.2 respectively represent hydrogen or substituted or non-substituted aryl), CAr.sup.1 Ar.sup.2 (wherein Ar.sup.1 and Ar.sup.2 represent the same meanings as mentioned above), O--CHAr.sup.1 Ar.sup.2 (wherein Ar.sup.1 and Ar.sup.2 represent the same meanings as mentioned above) or condensed aromatic ring!.
摘要:
A control device has a CPU for determining an opening time and a conversion time, set in a non-injection period between preceding and present injections, in an interception process every fuel injection, and a control circuit for controlling a converting unit, independent of the operation of the CPU, to convert an analog signal, indicating fuel pressure of an injector, into a converted value at the conversion time. The CPU determines a closing time from the opening time and the converted value in another interception process. The device has a driving circuit for starting the valve opening at the opening time to open the injector and to inject fuel from the opened injector into an engine and starting the valve closing at the closing time to close the injector and to stop the fuel injection when the injected fuel reaches a required quantity.
摘要:
The control system has a structure in which sensor apparatuses each having a data communication function are connected to an electronic control apparatus through a common communication line, and the sensors of the sensor apparatuses are connected to the electronic control apparatus through separate individual signal lines to transmit sensor signals to the electronic control apparatus. The electronic control apparatus is configured to, prior to transmitting communication data to one of the sensor apparatuses through the communication line, set the signal line connected to the selected sensor apparatus in a state in which the voltage of the signal line is outside a variation range corresponding to a voltage range of the sensor signal, and set the signal lines connected to the other sensor apparatuses to each of which the communication data is not addressed in a state in which the voltage of the signal line is within the variation range.
摘要:
A workpiece transporting apparatus includes a hand, a rotating portion for rotatably holding the hand, an arm provided in the hand and having one end provided at the rotating portion, and a holding portion provided in the hand and provided to another end of the arm for holding a workpiece, in which a center portion of the holding portion is disposed with a predetermined interval from an axial line extended from a rotational center of the rotating portion toward another end of the arm.
摘要:
The present invention regards the composition having a blood pressure reducing and/or elevation suppressing effect comprising a mannose-based oligosaccharide mass comprising 1 to 10 molecules of monosaccharides linked together, said molecules mainly comprising mannose. It is the object of the present invention to provide an economical and simple food and drink which has an excellent blood pressure reducing and/or elevation suppressing effect without changing ordinary eating habits much, and a composition ingestible with a food and drink which effectively uses waste resources such as coffee extraction residues.
摘要:
In a data processor for processing pieces of input data successively sampled, a memory unit and a plurality of data transferring units for transferring data are provided. Each of the plurality of data transferring units has an upper limit number of data items successively transferable when activated. An activating unit is provided. The activating unit is configured to successively activate, within a predetermined time frame, the data transferring units without all of the data transferring units being deactivated within the predetermined time frame to thereby successively transfer the pieces of input data to the memory unit so as to store the pieces of input data therein.
摘要:
Novel triazolo derivatives represented by the following formula and pharmaceutically acceptable salts thereof, as well as chemokine inhibitors containing the same as an effective component. These are useful as therapeutic agents for allergic diseases such as bronchial asthma and atopic dermatitis; therapeutic agents for inflammatory diseases such as chronic rheumatoid arthritis; therapeutic agents for autoimmune diseases such as ulcerative colitis and nephritis; and as anti-AIDS drugs.