公开(公告)号：US5683998A

公开(公告)日：1997-11-04

申请号：US432714

申请日：1995-05-02

申请人： Katsuhiro Shibayama ,  Tetsuya Makino ,  Takayuki Imaoka ,  Tetsuya Katou ,  Masayuki Kaneko

发明人： Katsuhiro Shibayama ,  Tetsuya Makino ,  Takayuki Imaoka ,  Tetsuya Katou ,  Masayuki Kaneko

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/495 ,  C07D243/12

CPC分类号： C07D487/04

摘要： Novel tricyclic triazolo derivatives and pharmaceutically acceptable salts thereof, which are useful as anti-inflammation agents, anti-allergy agents or anti-PAF agents as well as processes for producing the same are disclosed. The triazolo derivatives of the present invention are represented by the formula (I): ##STR1## �wherein R.sup.1 represents hydrogen, lower alkyl or C.sub.3 -C.sub.5 cycloalkyl; R.sup.2 and R.sup.3 respectively represent hydrogen, lower alkyl, lower alkoxy or halogen; W represents C.dbd.O or CR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 respectively represents hydrogen or lower alkyl); A represents C.sub.1 -C.sub.5 straight or branched saturated or unsaturated alkylene which may contain one or more hetero atoms; l represents 0 to 2, n represents 1 to 3, . . . represents single bond or double bond; Y represents N or C; Z represents C(B)Ar.sup.1 Ar.sup.2 (wherein B represents hydrogen, hydroxy or methoxy, Ar.sup.1 and Ar.sup.2 respectively represent hydrogen or substituted or non-substituted aryl), CAr.sup.1 Ar.sup.2 (wherein Ar.sup.1 and Ar.sup.2 represent the same meanings as mentioned above), O--CHAr.sup.1 Ar.sup.2 (wherein Ar.sup.1 and Ar.sup.2 represent the same meanings as mentioned above) or condensed aromatic ring!.

摘要翻译： 公开了可用作抗炎剂，抗过敏剂或抗PAF剂的新型三环三唑衍生物及其药学上可接受的盐及其制备方法。 本发明的三唑衍生物由式（I）表示：其中R 1表示氢，低级烷基或C 3 -C 5环烷基; R2和R3分别表示氢，低级烷基，低级烷氧基或卤素; W表示C = O或CR4R5（其中R4和R5分别表示氢或低级烷基）; A表示可含有一个或多个杂原子的C1-C5直链或支链饱和或不饱和亚烷基; l表示0〜2，n表示1〜3。 。 。 表示单键或双键; Y表示N或C; Z表示C（B）Ar1Ar2（其中B表示氢，羟基或甲氧基，Ar1和Ar2分别表示氢或取代或未取代的芳基），CAr1Ar2（其中Ar1和Ar2表示与上述相同的含义），O-CHAr1Ar2 （其中Ar1和Ar2表示与上述相同的含义）或稠合芳香环]。

公开(公告)号：US06492364B1

公开(公告)日：2002-12-10

申请号：US09601620

申请日：2000-09-22

申请人： Toshiya Takahashi ,  Takayuki Imaoka ,  Noriko Mori ,  Masayuki Kaneko ,  Koh Tanida ,  Yuichi Torii

发明人： Toshiya Takahashi ,  Takayuki Imaoka ,  Noriko Mori ,  Masayuki Kaneko ,  Koh Tanida ,  Yuichi Torii

IPC分类号： A61K3153

CPC分类号： A61K31/437 ,  A61K31/4545 ,  A61K31/497 ,  C07D471/04 ,  Y02P20/582

摘要： Novel triazolo derivatives represented by the following formula and pharmaceutically acceptable salts thereof, as well as chemokine inhibitors containing the same as an effective component. These are useful as therapeutic agents for allergic diseases such as bronchial asthma and atopic dermatitis; therapeutic agents for inflammatory diseases such as chronic rheumatoid arthritis; therapeutic agents for autoimmune diseases such as ulcerative colitis and nephritis; and as anti-AIDS drugs.

摘要翻译： 由下式表示的新型三唑衍生物及其药学上可接受的盐，以及含有与有效成分相同的趋化因子抑制剂。 这些可用作过敏性疾病如支气管哮喘和特应性皮炎的治疗剂; 用于炎性疾病如慢性类风湿性关节炎的治疗剂; 自身免疫疾病如溃疡性结肠炎和肾炎的治疗剂; 并作为抗艾滋病药物。

公开(公告)号：US20110184091A1

公开(公告)日：2011-07-28

申请号：US13121358

申请日：2009-09-29

申请人： Maki Mizuki ,  Nobuyuki Tomioka ,  Takayuki Imaoka ,  Shiro Honda ,  Noriyuki Hirano ,  Jun Misumi ,  Kaori Narimatsu

发明人： Maki Mizuki ,  Nobuyuki Tomioka ,  Takayuki Imaoka ,  Shiro Honda ,  Noriyuki Hirano ,  Jun Misumi ,  Kaori Narimatsu

IPC分类号： C08L63/00 ,  C08L53/00 ,  C08K7/04

CPC分类号： C08L63/00 ,  B32B27/04 ,  B32B27/38 ,  C08G59/4238 ,  C08G59/50 ,  C08G59/686 ,  C08J5/24 ,  C08J2363/00 ,  C08L53/02 ,  Y10T428/24994 ,  Y10T428/24995 ,  C08L2666/08

摘要： An epoxy resin composition comprising an epoxy resin [A], an amine-based curing agent [B] and a block copolymer [C] as components, wherein the epoxy resin [A] contains [Aa] an epoxy resin having at least one structure selected from a condensed polycyclic structure, biphenyl structure and oxazolidone ring structure; [Ab] an epoxy resin selected from a polyfunctional amine type epoxy resin [Ab1] and a liquid bisphenol type epoxy resin [Ab2], and the block copolymer [C] is at least one block copolymer selected from the group consisting of S-B-M, B-M and M-B-M. The present invention provides an epoxy resin composition that can be cured to form a cured product excellent in heat resistance, elastic modulus and toughness.

摘要翻译： 包含环氧树脂[A]，胺基固化剂[B]和嵌段共聚物[C]作为组分的环氧树脂组合物，其中环氧树脂[A]含有具有至少一个结构的环氧树脂 选自缩合多环结构，联苯结构和恶唑烷酮环结构; [Ab]选自多官能胺型环氧树脂[Ab1]和液体双酚型环氧树脂[Ab2]的环氧树脂，嵌段共聚物[C]为选自SBM，BM 和MBM。 本发明提供一种能够固化以形成耐热性，弹性模量和韧性优异的固化物的环氧树脂组合物。

公开(公告)号：US20110009528A1

公开(公告)日：2011-01-13

申请号：US12919285

申请日：2009-02-26

申请人： Nobuyuki Tomioka ,  Shiro Honda ,  Yuki Mitsutsuji ,  Maki Mizuki ,  Takayuki Imaoka

发明人： Nobuyuki Tomioka ,  Shiro Honda ,  Yuki Mitsutsuji ,  Maki Mizuki ,  Takayuki Imaoka

IPC分类号： C08L63/02

CPC分类号： C08L63/00 ,  C08G59/184 ,  C08G59/226 ,  C08G59/38 ,  C08G59/5033 ,  C08J5/24 ,  C08J2363/02 ,  C08L2666/22

摘要： It is an object of the present invention to provide a fiber reinforced composite material combining good properties such as toughness and impact resistance and to provide an epoxy resin composition to obtain this. This object is achieved by the an epoxy resin composition comprising the following [A], [B], [C], and [D]: [A] a diglycidyl ether-type epoxy resin having a molecular weight of 1,500 or more; [B] an epoxy resin in which an SP value of a structural unit thereof is greater by 1.5 to 6.5 than an SP value of a structural unit of [A]; [C] a diglycidyl ether-type epoxy resin having a molecular weight of 500 to 1,200; and [D] an epoxy resin curing agent, in a ratio that satisfies the following formulas (1) to (4): 0.2≦A/(A+B+C+E)≦0.6;  (1), 0.2≦B/(A+B+C+E)≦0.6;  (2), 0.15≦C/(A+B+C+E)≦0.4; and  (3), 0≦E/(A+B+C+E)≦0.2,  (4) wherein A, B, and C represent weights of [A], [B], and [C], respectively, and E represents a weight of an epoxy resin other than [A], [B], and [C].

摘要翻译： 本发明的目的是提供一种结合韧性和耐冲击性等良好性能的纤维增强复合材料，并提供一种环氧树脂组合物来获得。 该目的通过包含以下[A]，[B]，[C]和[D]的环氧树脂组合物来实现：[A]分子量为1,500以上的二缩水甘油醚型环氧树脂; [B]结构单元的SP值比[A]的结构单元的SP值大1.5〜6.5的环氧树脂; [C]分子量为500〜1200的二缩水甘油醚型环氧树脂; 和[D]环氧树脂固化剂，其比例满足下述式（1）〜（4）：0.2＆lt; lE; A /（A + B + C + E）＆nlE; 0.6; （1），0.2＆nlE; B /（A + B + C + E）＆nlE; 0.6; （2），0.15＆nlE; C /（A + B + C + E）＆nlE; 0.4; 和（3），0＆nlE; E /（A + B + C + E）＆nlE; 0.2，（4）其中A，B和C分别表示[A]，[B]和[C] E表示除[A]，[B]和[C]以外的环氧树脂的重量。

公开(公告)号：US08309631B2

公开(公告)日：2012-11-13

申请号：US12919285

申请日：2009-02-26

申请人： Nobuyuki Tomioka ,  Shiro Honda ,  Yuki Mitsutsuji ,  Maki Mizuki ,  Takayuki Imaoka

发明人： Nobuyuki Tomioka ,  Shiro Honda ,  Yuki Mitsutsuji ,  Maki Mizuki ,  Takayuki Imaoka

IPC分类号： C08G59/38 ,  C08G59/22

CPC分类号： C08L63/00 ,  C08G59/184 ,  C08G59/226 ,  C08G59/38 ,  C08G59/5033 ,  C08J5/24 ,  C08J2363/02 ,  C08L2666/22

摘要： It is an object of the present invention to provide a fiber reinforced composite material combining good properties such as toughness and impact resistance and to provide an epoxy resin composition to obtain this. This object is achieved by the an epoxy resin composition comprising the following [A], [B], [C], and [D]: [A] a diglycidyl ether-type epoxy resin having a molecular weight of 1,500 or more; [B] an epoxy resin in which an SP value of a structural unit thereof is greater by 1.5 to 6.5 than an SP value of a structural unit of [A]; [C] a diglycidyl ether-type epoxy resin having a molecular weight of 500 to 1,200; and [D] an epoxy resin curing agent, in a ratio that satisfies the following formulas (1) to (4): 0.2≦A/(A+B+C+E)≦0.6;  (1), 0.2≦B/(A+B+C+E)≦0.6;  (2), 0.15≦C/(A+B+C+E)≦0.4; and  (3), 0≦E/(A+B+C+E)≦0.2,  (4) wherein A, B, and C represent weights of [A], [B], and [C], respectively, and E represents a weight of an epoxy resin other than [A], [B], and [C].

摘要翻译： 本发明的目的是提供一种结合韧性和耐冲击性等良好性能的纤维增强复合材料，并提供一种环氧树脂组合物来获得。 该目的通过包含以下[A]，[B]，[C]和[D]的环氧树脂组合物来实现：[A]分子量为1,500以上的二缩水甘油醚型环氧树脂; [B]结构单元的SP值比[A]的结构单元的SP值大1.5〜6.5的环氧树脂; [C]分子量为500〜1200的二缩水甘油醚型环氧树脂; 和[D]环氧树脂固化剂，其比例满足下述式（1）〜（4）：0.2＆lt; lE; A /（A + B + C + E）＆nlE; 0.6; （1），0.2＆nlE; B /（A + B + C + E）＆nlE; 0.6; （2），0.15＆nlE; C /（A + B + C + E）＆nlE; 0.4; 和（3），0＆nlE; E /（A + B + C + E）＆nlE; 0.2，（4）其中A，B和C分别表示[A]，[B]和[C] E表示除[A]，[B]和[C]以外的环氧树脂的重量。

公开(公告)号：US06517635B2

公开(公告)日：2003-02-11

申请号：US09803588

申请日：2001-03-09

申请人： Kenichi Mitsumori ,  Yasuhiko Kasama ,  Akira Abe ,  Oh Eui Yeol ,  Tadahiro Ohmi ,  Takayuki Imaoka ,  Masayuki Toda

发明人： Kenichi Mitsumori ,  Yasuhiko Kasama ,  Akira Abe ,  Oh Eui Yeol ,  Tadahiro Ohmi ,  Takayuki Imaoka ,  Masayuki Toda

IPC分类号： B08B304

CPC分类号： H01L21/6708 ,  B08B3/022 ,  B08B3/041 ,  B08B3/123 ,  B08B2203/0288 ,  H01L21/67051

摘要： The wet treatment liquid feed nozzle of the invention comprises an introducing path having an introducing port, a discharging path having a discharging port, a crossing section formed by causing the introducing path and the discharging path to cross at the other ends thereof, a nozzle assembly having an opening section opening to an object to be treated, provided at the crossing section, and pressure control means, for controlling the difference between the pressure of the wet treatment liquid in contact with the object to be treated and the atmospheric pressure provided at least on the discharging path side so that the wet treatment liquid having been in contact with the object to be treated via the opening section does not flow to outside the discharging path.

摘要翻译： 本发明的湿式处理液体进料喷嘴包括一个具有一个引入口的引入通道，一个具有排出口的排出通道，一个通过使引入通道和排放通道在其另一端处交叉而形成的交叉部分，一个喷嘴组件 具有开口部分，设置在交叉部分处的待处理对象;以及压力控制装置，用于控制与待处理物体接触的湿处理液体的压力与至少提供的大气压力之间的差异 在放电路径侧，使得经由开口部分与待处理物体接触的湿处理液体不会流到排出路径的外部。

公开(公告)号：US06230722B1

公开(公告)日：2001-05-15

申请号：US09083348

申请日：1998-05-22

申请人： Kenichi Mitsumori ,  Yasuhiko Kasama ,  Akira Abe ,  Oh Eui Yeol ,  Tadahiro Ohmi ,  Takayuki Imaoka ,  Masayuki Toda

发明人： Kenichi Mitsumori ,  Yasuhiko Kasama ,  Akira Abe ,  Oh Eui Yeol ,  Tadahiro Ohmi ,  Takayuki Imaoka ,  Masayuki Toda

IPC分类号： B08B312

CPC分类号： H01L21/6708 ,  B08B3/022 ,  B08B3/041 ,  B08B3/123 ,  B08B2203/0288 ,  H01L21/67051

摘要： The wet treatment liquid feed nozzle of the invention comprises an introducing path 10 having an introducing port 7, a discharging path 12 having a discharging port 15, a crossing section 14 formed by causing the introducing path 10 and the discharging path 12 to cross at the other ends thereof, a nozzle assembly 50 having an opening section 6 opening to an object to be treated 1, provided at the crossing section 14, and pressure control means 13, for controlling the difference between the pressure of the wet treatment liquid in contact with the object to be treated 1 and the atmospheric pressure provided at least on the discharging path 12 side so that the wet treatment liquid having been in contact with the object to be treated 1 via the opening section 6 does not flow to outside the discharging path 12.

摘要翻译： 本发明的湿处理液体供给喷嘴包括具有引入口7的引入路径10，具有排出口15的排出路径12，通过使引入路径10和排出路径12在 设置在交叉部分14处的具有开口部分6的开口部分6的喷嘴组件50，以及压力控制装置13，用于控制接触到的湿处理液体的压力之间的差异 待处理物体1和至少设置在排出路径12侧的大气压力，使得经由开口部分6与待处理物体1接触的湿处理液体不会流到排出路径12的外部 。