公开(公告)号：US4622325A

公开(公告)日：1986-11-11

申请号：US591459

申请日：1984-03-20

申请人： Setsuro Fujii ,  Norio Unemi ,  Setsuo Takeda

发明人： Setsuro Fujii ,  Norio Unemi ,  Setsuo Takeda

IPC分类号： A61K31/505 ,  C07D239/54 ,  C07D239/553

CPC分类号： C07D239/553 ,  A61K31/505 ,  Y10S514/922

摘要： An anti-cancer composition for delivering 5-fluorouracil to cancer tissues in a warm-blooded animal, wherein the cancer is a cancer sensitive to 5-fluorouracil, comprising 1-n-hexylcarbamoyl-5-fluorouracil and uracil (or salt there-of), wherein the composition contains less than 0.1 mole of the 5-fluorouracil per mole of the uracil.

摘要翻译： 一种用于将5-氟尿嘧啶递送至温血动物的癌症组织的抗癌组合物，其中所述癌症是对5-氟尿嘧啶敏感的癌症，其包含1-正己基氨基甲酰基-5-氟尿嘧啶和尿嘧啶（或其中的盐） ），其中所述组合物每摩尔尿嘧啶含有少于0.1摩尔的5-氟尿嘧啶。

公开(公告)号：US4507301A

公开(公告)日：1985-03-26

申请号：US214022

申请日：1980-12-08

申请人： Setsuro Fujii ,  Norio Unemi ,  Setsuo Takeda

发明人： Setsuro Fujii ,  Norio Unemi ,  Setsuo Takeda

IPC分类号： A61K31/505 ,  C07D239/54 ,  C07D239/553

CPC分类号： C07D239/553 ,  A61K31/505 ,  Y10S514/922

摘要： An anti-cancer composition comprising a 5-fluorouracil (including derivatives thereof) and uracil (or salt thereof), is disclosed, wherein the composition contains less than 0.1 mole of the 5-fluorouracil per mole of the uracil.

摘要翻译： 公开了包含5-氟尿嘧啶（包括其衍生物）和尿嘧啶（或其盐）的抗癌组合物，其中组合物每摩尔尿嘧啶含有少于0.1摩尔的5-氟尿嘧啶。

公开(公告)号：US4481203A

公开(公告)日：1984-11-06

申请号：US212543

申请日：1980-12-03

申请人： Setsuro Fujii ,  Norio Unemi ,  Setsuo Takeda

发明人： Setsuro Fujii ,  Norio Unemi ,  Setsuo Takeda

IPC分类号： A61K31/505 ,  C07D239/54 ,  C07D239/553

CPC分类号： C07D239/553 ,  A61K31/505 ,  Y10S514/922

摘要： A composition for delivering 5-fluorouracil to cancer tissues, of a cancer sensitive to 5-fluorouracil, in warm blooded animals, comprising effective amounts of 1-(n-hexylcarbamoyl)-5-fluorouracil and uracil in a molar ratio of 1:0.1-10, respectively.

摘要翻译： 用于向温血动物中向5-氟尿嘧啶敏感的癌症组织递送5-氟尿嘧啶的组合物，其包含有效量的1-（正己基氨基甲酰基）-5-氟尿嘧啶和尿嘧啶的摩尔比为1:0.1 -10。

公开(公告)号：US5032680A

公开(公告)日：1991-07-16

申请号：US314924

申请日：1989-02-24

申请人： Tsutomu Kawai ,  Fumio Mori ,  Setsuo Takeda ,  Hitoshi Saito ,  Norio Unemi

发明人： Tsutomu Kawai ,  Fumio Mori ,  Setsuo Takeda ,  Hitoshi Saito ,  Norio Unemi

IPC分类号： C07H19/10

CPC分类号： C07H19/10

摘要： 2'-Deoxy-5-fluorouridine derivatives of the formula ##STR1## wherein, R.sup.1 is hydrogen atom or an acyl group and R.sup.2 and R.sup.3 are respectively hydrogen atom, an acyl group or a group of the formula ##STR2## wherein X.sup.1 and X.sup.2 are respectively oxygen atom or sulfur atom; R.sup.4 is a phenyl group, a benzyl group or a naphthyl group each of which may be substituted by an alkyl group, an alkoxyl group, an alkoxycarbonyl group, an alkylthio group, and acyl group, a halogen atom, trifluoromethyl group, nitro group, cyano group, carboxyl group and/or methylenedioxy group and R.sup.5 is an alkyl group, an alkenyl group or one of the groups represented by R.sup.4 which is the same as or different from R.sup.4, at least one of R.sup.2 and R.sup.3 being a group of the formula ##STR3## which exhibit excellent antitumour activities and have lower toxicity, methods of the production thereof and antitumour compositions containing said 2'-deoxy-5-fluorouridine derivatives.

公开(公告)号：US6153616A

公开(公告)日：2000-11-28

申请号：US8577

申请日：1998-01-16

申请人： Mohsen Daneshtalab ,  Yadagiri Bathini ,  Dai Nguyen ,  Inderjit Sidhu ,  Mark Abel ,  Chan Ha ,  Sameeh Salama ,  Jehangir Khan ,  Ronald Micetich ,  Tetsuo Furukawa ,  Norio Unemi

发明人： Mohsen Daneshtalab ,  Yadagiri Bathini ,  Dai Nguyen ,  Inderjit Sidhu ,  Mark Abel ,  Chan Ha ,  Sameeh Salama ,  Jehangir Khan ,  Ronald Micetich ,  Tetsuo Furukawa ,  Norio Unemi

IPC分类号： C07D521/00 ,  A61K31/496 ,  C07D403/10 ,  C07D403/14

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

摘要： A compound of formula I, or an optical isomer or pharmaceutically acceptable salt thereof, ##STR1## is disclosed as well as a pharmaceutical composition and a method of treating or preventing a fungal infection using the compound.

摘要翻译： 公开了式I化合物或其光学异构体或其药学上可接受的盐，以及药物组合物和使用该化合物治疗或预防真菌感染的方法。

公开(公告)号：US4946951A

公开(公告)日：1990-08-07

申请号：US225984

申请日：1988-07-29

申请人： Yukio Tada ,  Atsuhiko Uemura ,  Mitsugi Yasumoto ,  Setsuo Takeda ,  Hitoshi Saito ,  Norio Unemi

发明人： Yukio Tada ,  Atsuhiko Uemura ,  Mitsugi Yasumoto ,  Setsuo Takeda ,  Hitoshi Saito ,  Norio Unemi

IPC分类号： B09B3/00 ,  A61K31/70 ,  B02C18/00 ,  C07H19/06 ,  C07H19/073

CPC分类号： C07H19/06

摘要： Disclosed is a 2'-deoxy-5-fluorouridine derivative of the formula ##STR1## wherein one of R.sub.1 and R.sub.2 is a benzyl group which may optionally have substituent selected from the group consisting of C.sub.1 -C.sub.6 alkyl group, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.3 halogenated alkyl group, halogen atom, hydroxyl group and nitro group on the phenyl ring, and the other constitutes an amino acid residue, or a salt thereof. The compounds are useful for treating cancer.

摘要翻译： 公开了式（CHEM）2分钟的脱氧-5-氟尿苷衍生物，其中R 1和R 2之一是可以任选具有选自C 1 -C 6烷基，C 1 -C 6烷氧基的取代基的苄基 苯基环上的C1-C3卤代烷基，卤原子，羟基和硝基，另一个构成氨基酸残基或其盐。 该化合物可用于治疗癌症。

公开(公告)号：US4897503A

公开(公告)日：1990-01-30

申请号：US159590

申请日：1988-01-27

申请人： Tetsuji Asao ,  Setsuo Takeda ,  Yoshikazu Sugimoto ,  Toshiyuki Toko ,  Yuji Yamada ,  Kazuo Ogawa ,  Norio Unemi

发明人： Tetsuji Asao ,  Setsuo Takeda ,  Yoshikazu Sugimoto ,  Toshiyuki Toko ,  Yuji Yamada ,  Kazuo Ogawa ,  Norio Unemi

IPC分类号： C07F9/12

CPC分类号： C07F9/12

摘要： This invention provides a 1,1,2-triaryl-1-butene derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, one of R.sub.3 and R.sub.4 is a lower alkyl group and the other is a group of the formula ##STR2## (in which R.sub.5 is a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom or --OPO(OH).sub.2 group); or a pharmacologically acceptable salt thereof, its preparation and agents containing the derivative for treating mammary cancer and anovulatory infertility.