公开(公告)号：US10751386B2

公开(公告)日：2020-08-25

申请号：US15981762

申请日：2018-05-16

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Jason P. Schrum ,  Alexander Aristarkhov

IPC: A61K49/00 ,  A61K39/00 ,  A61K39/38 ,  A61K38/17 ,  C07K14/47 ,  A61K45/06 ,  A61K38/46 ,  A61K48/00

Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing.

公开(公告)号：US09937233B2

公开(公告)日：2018-04-10

申请号：US15248053

申请日：2016-08-26

Applicant: ModernaTX, Inc.

Inventor： Jason P. Schrum ,  Stephane Bancel ,  Noubar B. Afeyan ,  Kenechi Ejebe

IPC: A61K31/70 ,  C07H21/04 ,  A61K38/19 ,  A61K48/00 ,  A61K31/495 ,  A61K39/395 ,  A01K67/00

CPC classification number: A61K38/193 ,  A61K31/395 ,  A61K31/495 ,  A61K31/7088 ,  A61K31/7115 ,  A61K38/00 ,  A61K38/13 ,  A61K38/195 ,  A61K38/28 ,  A61K39/3955 ,  A61K48/00 ,  A61K48/0066 ,  A61K48/0075 ,  A61K48/0083 ,  C07K14/62 ,  C07K14/685 ,  A61K2300/00

Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.

公开(公告)号：US20210236655A1

公开(公告)日：2021-08-05

申请号：US16930720

申请日：2020-07-16

Applicant: ModernaTX, Inc.

Inventor： Jason P. Schrum ,  Gregory J. Sieczkiewicz ,  Kenechi Ejebe ,  Sayda M. Elbashir

IPC: A61K48/00 ,  C12N15/113 ,  C07H21/02 ,  C07H19/10 ,  C12P21/00 ,  C12N5/071 ,  C12N15/10 ,  C12N15/11 ,  C07K16/00 ,  C07K16/28 ,  G01N33/559 ,  C12N15/67

Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful for production of proteins.