公开(公告)号：US11752206B2

公开(公告)日：2023-09-12

申请号：US16494130

申请日：2018-03-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Shinu John ,  Andrew J. Bett ,  Danilo R. Casimiro ,  Dai Wang ,  Lan Zhang

IPC: A61K39/245 ,  A61P31/22 ,  A61K9/00 ,  A61K9/51 ,  A61K39/39 ,  C07K14/005 ,  C12N7/00 ,  A61K47/69 ,  A61K39/00

CPC classification number: A61K39/245 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5146 ,  A61K39/39 ,  A61K47/6929 ,  A61P31/22 ,  C07K14/005 ,  C12N7/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/70 ,  C07K2319/02 ,  C07K2319/40 ,  C12N2710/16622 ,  C12N2710/16634

Abstract: Herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.

公开(公告)号：US20220401551A1

公开(公告)日：2022-12-22

申请号：US17840478

申请日：2022-06-14

Applicant: ModernaTX, Inc.

Inventor： Jack F. Kramarczyk ,  Kimberly Hassett ,  Shinu John ,  Phil White ,  Andrea Carfi

IPC: A61K39/245 ,  C12N7/00

Abstract: Aspects of the disclosure relate to methods for producing an antigen-specific immune response to human cytomegalovirus (hCMV) in a subject by administering mRNA vaccines.

公开(公告)号：US20220347292A1

公开(公告)日：2022-11-03

申请号：US17641967

申请日：2020-09-11

Applicant: ModernaTX, Inc.

Inventor： Lori Panther ,  Shinu John ,  Tal Zaks

IPC: A61K39/245 ,  A61P31/22

Abstract: Aspects of the invention relate to methods for producing an antigen-specific immune response to human cytomegalovirus (hCMV) in a subject by administering mRNA vaccines comprising hCMV antigenic polypeptides gH, gL, UL128, UL130, UL131 A and gB formulated in lipid nanoparticles, wherein the antigen-specific immune response to hCMV results in neutralizing antibodies that have i) a geometric mean titer of at least 3-fold against epithelial cell infection or ii) a geometric mean ratio of 9-41 against epithelial cell infection or iii) a geometric mean ratio of 4-8-fold against fibroblast infection.

公开(公告)号：US11484590B2

公开(公告)日：2022-11-01

申请号：US16833409

申请日：2020-03-27

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Shinu John ,  Kambiz Mousavi

IPC: A61K39/245 ,  A61K39/12 ,  C12N7/00 ,  C07K14/005 ,  A61K31/7105 ,  A61K31/7115 ,  A61K39/39 ,  A61K39/00

Abstract: The disclosure describes HCMV ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US11197927B2

公开(公告)日：2021-12-14

申请号：US16864566

申请日：2020-05-01

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Shinu John

IPC: A61K39/245 ,  A61P31/22 ,  A61K39/00

Abstract: The disclosure relates to HCMV ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20200246453A1

公开(公告)日：2020-08-06

申请号：US16833409

申请日：2020-03-27

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Shinu John ,  Kambiz Mousavi

IPC: A61K39/245 ,  C07K14/005 ,  A61K39/39 ,  A61K31/7115 ,  A61K31/7105 ,  C12N7/00 ,  A61K39/12

Abstract: The disclosure describes HCMV ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US10383937B2

公开(公告)日：2019-08-20

申请号：US16006526

申请日：2018-06-12

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Shinu John ,  Kambiz Mousavi

IPC: C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K39/245 ,  C07K14/005 ,  A61K31/7105 ,  A61K31/7115

Abstract: HCMV ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20250082748A1

公开(公告)日：2025-03-13

申请号：US18812841

申请日：2024-08-22

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Shinu John ,  Kambiz Mousavi

IPC: A61K39/245 ,  A61K31/7105 ,  A61K31/7115 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  C07K14/005 ,  C12N7/00

Abstract: The disclosure describes HCMV ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20240173400A1

公开(公告)日：2024-05-30

申请号：US18481204

申请日：2023-10-04

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Shinu John ,  Andrew J. Bett ,  Danilo R. Casimiro

IPC: A61K39/245 ,  A61K31/7105 ,  A61K31/7115 ,  A61K39/12 ,  A61P31/22 ,  A61K39/00

CPC classification number: A61K39/245 ,  A61K31/7105 ,  A61K31/7115 ,  A61K39/12 ,  A61P31/22 ,  A61K2039/53 ,  A61K2039/55555 ,  C12N2710/16634 ,  Y02A50/30

Abstract: Provided herein are immunogenic compositions comprising mRNA encoding herpes simplex virus polypeptides, as well as methods of using the immunogenic compositions.

公开(公告)号：US20240156952A1

公开(公告)日：2024-05-16

申请号：US18354574

申请日：2023-07-18

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Shinu John ,  Andrew J. Bett ,  Danilo R. Casimiro ,  Dai Wang ,  Lan Zhang

IPC: A61K39/245 ,  A61K9/00 ,  A61K9/51 ,  A61K39/39 ,  A61K47/69 ,  A61P31/22 ,  C07K14/005 ,  C12N7/00

CPC classification number: A61K39/245 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5146 ,  A61K39/39 ,  A61K47/6929 ,  A61P31/22 ,  C07K14/005 ,  C12N7/00 ,  A61K2039/53

Abstract: Herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.