公开(公告)号：US07890171B2

公开(公告)日：2011-02-15

申请号：US11738251

申请日：2007-04-20

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

IPC分类号： A61N1/00

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种装置包括可植入装置，例如具有装置主体的长期可植入装置。 一个或多个化学传感器与装置本体结合。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US20070191921A1

公开(公告)日：2007-08-16

申请号：US11738251

申请日：2007-04-20

申请人： Qingsheng Zhu ,  Ronald Heil ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald Heil ,  Mudit Jain

IPC分类号： A61N1/05

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种装置包括可植入装置，例如具有装置主体的长期可植入装置。 一个或多个化学传感器与装置本体结合。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US20050070768A1

公开(公告)日：2005-03-31

申请号：US10677144

申请日：2003-09-30

申请人： Qingsheng Zhu ,  Ronald Heil ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald Heil ,  Mudit Jain

IPC分类号： A61B5/00 ,  A61N1/05

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种装置包括可植入装置，例如具有装置主体的长期可植入装置。 一个或多个化学传感器与装置本体结合。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US20110098547A1

公开(公告)日：2011-04-28

申请号：US12984161

申请日：2011-01-04

申请人： Qingsheng Zhu ,  Ronald W. Heil, JR. ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald W. Heil, JR. ,  Mudit Jain

IPC分类号： A61B5/145

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种装置包括可植入装置，例如具有装置主体的长期可植入装置。 一个或多个化学传感器与装置本体结合。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US08825155B2

公开(公告)日：2014-09-02

申请号：US13223919

申请日：2011-09-01

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/362 ,  A61N1/36 ,  A61N1/368 ,  A61N1/05

CPC分类号： A61N1/3627 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/36114 ,  A61N1/3625 ,  A61N1/368 ,  A61N1/3684

摘要： Disclosed are certain methods, apparatus, and processor-readable mediums that may be used to treat a conduction abnormality of the heart. In one example, the apparatus includes an implantable pacing profile generator configured to generate a specified pacing electrostimulation profile for delivery to a heart via electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including a first pulse for delivery via a first electrode; and a second pulse for delivery via a second electrode; and wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other.

摘要翻译： 公开了可用于治疗心脏传导异常的某些方法，装置和处理器可读介质。 在一个示例中，该装置包括植入式起搏分布生成器，其被配置为产生指定的起搏电刺激曲线，用于经由靠近His束的位于心脏右心室附近的电极的电极递送至心脏，起搏曲线包括第一 用于经由第一电极传送的脉冲; 以及用于经由第二电极传送的第二脉冲; 并且其中所述第一和第二脉冲在时间上至少部分同时并且彼此极性相反。

公开(公告)号：US08326423B2

公开(公告)日：2012-12-04

申请号：US12147317

申请日：2008-06-26

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/372

CPC分类号： A61N1/37 ,  A61N1/3627

摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by delivering pulses to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, a catheter arrangement includes a fixation mechanism to attach the catheter arrangement to heart tissue, individually-addressable electrodes for providing pacing signals to the heart tissue, and an elongated structure that supports the fixation mechanism and the electrodes. The elongated structure is used to direct an end thereof to the target region in the right ventricle, and deliver an electrical pacing signal to different portions within the target region of the heart when the fixation mechanism is operative to attach to heart tissue and also when the fixation mechanism is not attaching the catheter arrangement to heart tissue.

摘要翻译： 工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。 某些方面涉及通过将脉搏递送到心脏位置，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/压力， 或其组合。 在一个实施例中，导管装置包括用于将导管装置附接到心脏组织的固定机构，用于向心脏组织提供起搏信号的单独寻址电极，以及支撑固定机构和电极的细长结构。 细长结构用于将其末端引导到右心室中的目标区域，并且当固定机构可操作地附接到心脏组织时，以及当心脏组织工作时，将电起搏信号递送到心脏的目标区域内的不同部分 固定机构不将导管装置附接到心脏组织。

公开(公告)号：US20120209130A1

公开(公告)日：2012-08-16

申请号：US13456795

申请日：2012-04-26

申请人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

发明人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

IPC分类号： A61B5/0402 ,  A61B7/00

CPC分类号： A61B7/04 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/742 ,  A61B7/023 ,  G06F19/00

摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

摘要翻译： 用于输出心音的装置包括可植入系统和外部系统。 可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。 外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。 可植入系统还可以包括用于检测心脏电信号的传感器。 在这种情况下，还输出表示心电信号的输出。

公开(公告)号：US20120041503A1

公开(公告)日：2012-02-16

申请号：US13282163

申请日：2011-10-26

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/365 ,  A61N1/37 ,  A61N1/362

CPC分类号： A61N1/3627

摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by generating pulses for delivery to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, an implantable pulse generator includes circuitry for generating pacing profiles, with signals of opposite polarities, specifically selected for delivery on electrodes at a site near the septal wall of a right ventricle of the heart.

摘要翻译： 工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。 某些方面涉及起搏和/或作图，通过产生用于递送到心脏部位的脉搏，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/ 压力或其组合。 在一个实施例中，可植入脉冲发生器包括用于产生具有相反极性的信号的起搏曲线的电路，其具体选择用于在靠近心脏右心室隔壁的位置处的电极上传送。

公开(公告)号：US20120041500A1

公开(公告)日：2012-02-16

申请号：US13211937

申请日：2011-08-17

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/3627

摘要： According to one aspect, various methods and apparatus are used for treating a condition of a patient's heart, and for monitoring cardiac operation. In one approach consistent therewith, an electrode arrangement is placed in a right ventricle of the heart. The electrode arrangement is used to capture the myocardium for re-synchronization of the left and right ventricles by providing first and second signal components having opposite polarity on respective electrodes. The electrode arrangement is connected to an implantable CRM device that has the capability of pacing/sensing atrium, pacing/sensing ventricles, and deliver defibrillation therapy from the right side of the heart. The CRM device captures ventricular contractions to treat conduction abnormalities in one or more of the ventricles.

摘要翻译： 根据一个方面，使用各种方法和装置来治疗患者心脏的状况，并用于监测心脏手术。 在与其一致的一种方法中，将电极装置放置在心脏的右心室中。 电极装置用于通过在相应的电极上提供具有相反极性的第一和第二信号分量来捕获心肌以重新同步左心室和右心室。 电极装置连接到具有起搏/感测心房，起搏/感测心室的能力的可植入CRM装置，并且从心脏的右侧输送除颤疗法。 CRM设备捕获心室收缩以治疗一个或多个心室中的传导异常。

公开(公告)号：US08014861B2

公开(公告)日：2011-09-06

申请号：US12147293

申请日：2008-06-26

申请人： Qingsheng Zhu ,  Daniel Felipe Ortega

发明人： Qingsheng Zhu ,  Daniel Felipe Ortega

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/36114 ,  A61N1/3625 ,  A61N1/368 ,  A61N1/3684

摘要： Tools and methods are particularly suited for certain cardiac conditions advantaged by pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by delivering pulses to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. Other specific aspects include: determining a pacing threshold, beyond the capture threshold, to improve heart function; delivering pulses of opposite polarity to achieve such heart-function improvement; bi-ventricular pacing from a lead in the right ventricle for such improved heart function; delivering pulses of opposite polarity at a site near the His bundle; electrode-based His-pacing, without penetrating the myocardium; generating and/or delivering multiple pacing profiles including a pacing profile that delivers pulses of opposite polarity and another pacing profile; delivering a pacing profile to generate a synchronous contraction of the septal wall and free wall of the LV from a RV pacing location; and treating one or more of distal LBBB and/or diffuse LBBB by pacing at a site near the His bundle.

摘要翻译： 工具和方法特别适用于通过在右心室中的引线引导右心室和左心室有利的某些心脏状况，以促进用于再同步的机械和/或电同步收缩。 某些方面涉及通过将脉搏递送到心脏位置，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/压力， 或其组合。 其他具体方面包括：确定超出捕获阈值的起搏阈值，以改善心脏功能; 递送相反极性的脉冲以实现这种心脏功能的改善; 双心室起搏从右心室的引导改善心脏功能; 在His束附近的位置递送相反极性的脉冲; 基于电极的His起搏，不渗透心肌; 生成和/或递送多个起搏分布，包括递送相反极性的脉冲和另一起搏分布的起搏分布; 提供起搏剖面以产生来自RV起搏位置的LV的隔膜壁和自由壁的同步收缩; 并通过在靠近His束的位置进行起搏来治疗远端LBBB和/或扩散LBBB中的一种或多种。