公开(公告)号：US11912715B2

公开(公告)日：2024-02-27

申请号：US17374237

申请日：2021-07-13

Applicant: Novartis AG

Inventor： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  Vanessa Marx ,  Daniel Poon ,  James Clifford Sutton ,  Benjamin R. Taft ,  Lifeng Wan ,  Aregahegn Yifru ,  Qian Zhao

IPC: C07D487/14 ,  C07D471/14 ,  C07D498/14 ,  A61P31/16 ,  A61K31/551 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5383 ,  A61K31/5025

CPC classification number: C07D487/14 ,  A61K31/5025 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5383 ,  A61K31/551 ,  A61P31/16 ,  C07D471/14 ,  C07D498/14

Abstract: The invention provides compounds of Formula (I):




as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US11787785B2

公开(公告)日：2023-10-17

申请号：US17693759

申请日：2022-03-14

Applicant: NOVARTIS AG

Inventor： Simone Bonazzi ,  Artiom Cernijenko ,  Jennifer Stroka Cobb ,  Natalie Alysia Dales ,  Janetta Dewhurst ,  Matthew James Hesse ,  Rama Jain ,  John Ryan Kerrigan ,  Hasnain Ahmed Malik ,  James R. Manning ,  Gary O'Brien ,  Andrew W. Patterson ,  Noel Marie-France Thomsen ,  Pamela Y F Ting

IPC: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

CPC classification number: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US11098051B2

公开(公告)日：2021-08-24

申请号：US16328616

申请日：2017-08-25

Applicant: Novartis AG

Inventor： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  Vanessa Marx ,  Daniel Poon ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Aregahegn Yifru ,  Qian Zhao

IPC: C07D487/14 ,  C07D471/14 ,  C07D498/14 ,  A61P31/16 ,  A61K31/16 ,  A61K31/5025 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5383 ,  A61K31/551

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US10858366B2

公开(公告)日：2020-12-08

申请号：US16083089

申请日：2017-03-07

Applicant: Novartis AG

Inventor： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Qian Zhao

IPC: C07D487/14 ,  C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  A61P31/16 ,  C07D513/14

Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.