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公开(公告)号：US07450236B2
公开(公告)日：2008-11-11
申请号：US10932071
申请日：2004-09-02
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A sensor unit includes a dielectric block, a thin film layer and a reference surface. The thin film layer is formed on the upper surface of the dielectric block and the reference surface is coplanar with the upper surface of the dielectric block. The sensor unit is held in a predetermined position. A light beam is caused to enter the dielectric block to impinge upon the interface between the upper surface of the dielectric block and the thin film layer so that total internal reflection conditions are satisfied at the interface. Information on an analyte on the thin film layer is obtained on the basis of the light beam reflected at the interface. Displacement of the interface is measured by measuring displacement of the reference surface and the position of the sensor unit is adjusted according to the displacement of the reference surface.
摘要翻译： 传感器单元包括介质块，薄膜层和参考表面。 在介质块的上表面上形成薄膜层，并且参考表面与介质块的上表面共面。 传感器单元保持在预定位置。 导致光束进入介电块以撞击在介质块的上表面和薄膜层之间的界面上，使得在界面处满足全内反射条件。 基于在界面处反射的光束获得关于薄膜层上的分析物的信息。 通过测量参考表面的位移来测量界面的位移，并且根据参考表面的位移调节传感器单元的位置。
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公开(公告)号：US20050046854A1
公开(公告)日：2005-03-03
申请号：US10932071
申请日：2004-09-02
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： A sensor unit includes a dielectric block, a thin film layer and a reference surface. The thin film layer is formed on the upper surface of the dielectric block and the reference surface is coplanar with the upper surface of the dielectric block. The sensor unit is held in a predetermined position. A light beam is caused to enter the dielectric block to impinge upon the interface between the upper surface of the dielectric block and the thin film layer so that total internal reflection conditions are satisfied at the interface. Information on an analyte on the thin film layer is obtained on the basis of the light beam reflected at the interface. Displacement of the interface is measured by measuring displacement of the reference surface and the position of the sensor unit is adjusted according to the displacement of the reference surface.
摘要翻译： 传感器单元包括介质块，薄膜层和参考表面。 在介质块的上表面上形成薄膜层，并且参考表面与介质块的上表面共面。 传感器单元保持在预定位置。 导致光束进入介电块以撞击在介质块的上表面和薄膜层之间的界面上，使得在界面处满足全内反射条件。 基于在界面处反射的光束获得关于薄膜层上的分析物的信息。 通过测量参考表面的位移来测量界面的位移，并且根据参考表面的位移调节传感器单元的位置。
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公开(公告)号：US20060039003A1
公开(公告)日：2006-02-23
申请号：US11256151
申请日：2005-10-24
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： Disclosed herein is a measuring apparatus equipped with a plurality of measuring units. Each measuring unit includes a dielectric block, a thin film layer formed on the dielectric block, and a sample holding mechanism for holding a sample on the thin film layer. The measuring apparatus is further equipped with an optical system for making a light beam enter the dielectric block at an angle of incidence so that a total internal reflection condition is satisfied at an interface between the dielectric block and the thin film layer, and photodetectors for measuring the intensity of the light beam totally reflected at the interface. The optical system is constructed so that light beams simultaneously enter the dielectric blocks of the measuring units. The number of photodetectors corresponds to the number of the light beams.
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公开(公告)号：US20080088847A1
公开(公告)日：2008-04-17
申请号：US11723232
申请日：2007-03-19
申请人： Katsuaki Muraishi , Hitoshi Shimizu
发明人： Katsuaki Muraishi , Hitoshi Shimizu
IPC分类号： G01N21/47
CPC分类号： G01N21/553 , G01N21/05 , G01N21/11 , G01N2021/0346 , G01N2201/021
摘要： A sensor unit is for use in a surface plasmon resonance (SPR) assay apparatus having an assay stage. A total reflection prism is supported on a stage surface of the assay stage, and has a sensing surface positioned on an upper surface thereof. The sensing surface receives illuminating light applied thereto to reflect the illuminating light. The assay apparatus receives the illuminating light reflected by the sensing surface, for measuring reaction of a sample. Two engageable ridges are disposed on first and second lateral faces of the prism which are so positioned that the sensing surface is disposed between, and keep the prism positioned on the stage surface by engagement with a retention mechanism of the assay apparatus. Furthermore, a grip portion is formed at a first end of the prism, and adapted to holding of the prism.
摘要翻译： 传感器单元用于具有测定阶段的表面等离子体共振（SPR）测定装置。 全反射棱镜支撑在测定阶段的台表面上，并且具有位于其上表面上的感测表面。 感测表面接收施加到其上的照明光以反射照明光。 测定装置接收由感测表面反射的照射光，用于测量样品的反应。 两个可接合的脊设置在棱镜的第一和第二侧面上，其位置使得感测表面设置在棱镜之间并且通过与测定装置的保持机构接合而将棱镜保持在台面上。 此外，夹持部形成在棱镜的第一端，并且适于保持棱镜。
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公开(公告)号：US07075654B2
公开(公告)日：2006-07-11
申请号：US11256151
申请日：2005-10-24
CPC分类号： G01N21/553
摘要： Disclosed herein is a measuring apparatus equipped with a plurality of measuring units. Each measuring unit includes a dielectric block, a thin film layer formed on the dielectric block, and a sample holding mechanism for holding a sample on the thin film layer. The measuring apparatus is further equipped with an optical system for making a light beam enter the dielectric block at an angle of incidence so that a total internal reflection condition is satisfied at an interface between the dielectric block and the thin film layer, and photodetectors for measuring the intensity of the light beam totally reflected at the interface. The optical system is constructed so that light beams simultaneously enter the dielectric blocks of the measuring units. The number of photodetectors corresponds to the number of the light beams.
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公开(公告)号：US07545501B2
公开(公告)日：2009-06-09
申请号：US11723232
申请日：2007-03-19
申请人： Katsuaki Muraishi , Hitoshi Shimizu
发明人： Katsuaki Muraishi , Hitoshi Shimizu
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/05 , G01N21/11 , G01N2021/0346 , G01N2201/021
摘要： A sensor unit is for use in a surface plasmon resonance (SPR) assay apparatus having an assay stage. A total reflection prism is supported on a stage surface of the assay stage, and has a sensing surface positioned on an upper surface thereof. The sensing surface receives illuminating light applied thereto to reflect the illuminating light. The assay apparatus receives the illuminating light reflected by the sensing surface, for measuring reaction of a sample. Two engageable ridges are disposed on first and second lateral faces of the prism which are so positioned that the sensing surface is disposed between, and keep the prism positioned on the stage surface by engagement with a retention mechanism of the assay apparatus. Furthermore, a grip portion is formed at a first end of the prism, and adapted to holding of the prism.
摘要翻译： 传感器单元用于具有测定阶段的表面等离子体共振（SPR）测定装置。 全反射棱镜支撑在测定阶段的台表面上，并且具有位于其上表面上的感测表面。 感测表面接收施加到其上的照明光以反射照明光。 测定装置接收由感测表面反射的照射光，用于测量样品的反应。 两个可接合的脊设置在棱镜的第一和第二侧面上，其位置使得感测表面设置在棱镜之间并且通过与测定装置的保持机构接合而将棱镜保持在台面上。 此外，夹持部形成在棱镜的第一端，并且适于保持棱镜。
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公开(公告)号：US07030988B2
公开(公告)日：2006-04-18
申请号：US10102203
申请日：2002-03-21
IPC分类号： G01N21/55
CPC分类号： G01N21/553
摘要： Disclosed herein is a measuring apparatus equipped with a plurality of measuring units. Each measuring unit includes a dielectric block, a thin film layer formed on the dielectric block, and a sample holding mechanism for holding a sample on the thin film layer. The measuring apparatus is further equipped with an optical system for making a light beam enter the dielectric block at an angle of incidence so that a total internal reflection condition is satisfied at an interface between the dielectric block and the thin film layer, and photodetectors for measuring the intensity of the light beam totally reflected at the interface. The optical system is constructed so that light beams simultaneously enter the dielectric blocks of the measuring units. The number of photodetectors corresponds to the number of the light beams.
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公开(公告)号：US07830521B2
公开(公告)日：2010-11-09
申请号：US11864711
申请日：2007-09-28
IPC分类号： G01N21/00
CPC分类号： G01N21/553 , G01N2021/157
摘要： Provided are a detection apparatus, a detection method and an optically transparent member, which can detect a decrease in a precision. A convolution is performed by a convolution portion 80 contained in an image processing portion 38, to acquire the distribution information indicating the light intensity distribution of a light beam, which is totally reflected at the interface and which is incident at a plurality of angles to an dielectric block 52 so as to be totally reflected at the interface of the dielectric block 52. A spatial frequency resolution is performed on the light intensity distribution indicated by the distribution information acquired, by a detection precision evaluating portion 86 contained in the image processing portion 38, to thereby derive the light intensity distribution of each spatial frequency of the light beam. The precision is detected by comparing the light intensity distribution derived, with a threshold value predetermined for each spatial frequency.
摘要翻译： 提供了能够检测精度降低的检测装置，检测方法和光学透明构件。 通过包含在图像处理部分38中的卷积部分80执行卷积，以获取指示在该界面处被全反射并以多个角度入射的光束的光强度分布的分布信息 介质块52，以便在介质块52的界面处被全反射。通过由图像处理部分38中包含的检测精度评估部分86对由所获取的分布信息指示的光强度分布执行空间频率分辨率 ，从而导出光束的每个空间频率的光强度分布。 通过将导出的光强度分布与针对每个空间频率预定的阈值进行比较来检测精度。
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19.发明申请公开(公告)号：US20080079951A1
公开(公告)日：2008-04-03
申请号：US11864711
申请日：2007-09-28
IPC分类号： G01B11/30
CPC分类号： G01N21/553 , G01N2021/157
摘要： Provided are a detection apparatus, a detection method and an optically transparent member, which can detect a decrease in a precision. A convolution is performed by a convolution portion 80 contained in an image processing portion 38, to acquire the distribution information indicating the light intensity distribution of a light beam, which is totally reflected at the interface and which is incident at a plurality of angles to an dielectric block 52 so as to be totally reflected at the interface of the dielectric block 52. A spatial frequency resolution is performed on the light intensity distribution indicated by the distribution information acquired, by a detection precision evaluating portion 86 contained in the image processing portion 38, to thereby derive the light intensity distribution of each spatial frequency of the light beam. The precision is detected by comparing the light intensity distribution derived, with a threshold value predetermined for each spatial frequency.
摘要翻译： 提供了能够检测精度降低的检测装置，检测方法和光学透明构件。 通过包含在图像处理部分38中的卷积部分80执行卷积，以获取指示在该界面处被全反射并以多个角度入射的光束的光强度分布的分布信息 介质块52，以便在介质块52的界面处被完全反射。 由包含在图像处理部分38中的检测精度评估部分86对由所获取的分布信息指示的光强度分布执行空间频率分辨率，从而导出光束的每个空间频率的光强度分布。 通过将导出的光强度分布与针对每个空间频率预定的阈值进行比较来检测精度。
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公开(公告)号：US07348587B2
公开(公告)日：2008-03-25
申请号：US10175425
申请日：2002-06-20
申请人： Hitoshi Shimizu , Nobuhiko Ogura
发明人： Hitoshi Shimizu , Nobuhiko Ogura
IPC分类号： G03B42/08
CPC分类号： G01N21/76 , G01N21/6452 , G01N2021/6484
摘要： A method for producing biochemical analysis data includes the steps of collecting light selectively released from a plurality of light releasable regions two-dimensionally formed to be spaced apart from each other in a sample placed on a sample stage by a plurality of light guide member each of which is disposed to face one of the plurality of light releasable regions, leading the thus collected light to a light detector and photoelectrically detecting the light by the light detector. According to this method, it is possible to produce biochemical analysis data having high quantitative characteristics by photoelectrically detecting light emitted from a plurality of light releasable regions even in the case where the plurality of light releasable regions labeled with a labeling substance are formed in a sample at a high density.
摘要翻译： 一种生化分析数据的制造方法，其特征在于，在多个导光部件中，通过多个导光部件收集从放置在样品台上的样品彼此间隔开的二维形成的多个可光释放区域中选择性地剥离的光 其被设置为面对多个可光释放区域中的一个，将由此收集的光导向光检测器并通过光检测器光电检测光。 根据该方法，即使在标记有标记物质的多个可光剥离区域形成在样品中的情况下，也可以通过光电检测从多个可光释放区域发出的光来生成具有高定量特性的生化分析数据 以高密度。
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