公开(公告)号：US4745117A

公开(公告)日：1988-05-17

申请号：US844528

申请日：1986-03-27

申请人： Kikuo Ishizumi ,  Fujio Antoku ,  Isamu Maruyama ,  Atuyuki Kojima

发明人： Kikuo Ishizumi ,  Fujio Antoku ,  Isamu Maruyama ,  Atuyuki Kojima

IPC分类号： C07D209/48 ,  A61K31/425 ,  A61K31/428 ,  A61K31/435 ,  A61K31/495 ,  A61P25/00 ,  A61P25/18 ,  A61P25/20 ,  C07D209/76 ,  C07D275/06 ,  C07D405/06 ,  C07D417/12 ,  C07D491/18 ,  C07D417/14

CPC分类号： C07D275/06 ,  C07D417/12

摘要： A compound of the formula: ##STR1## wherein A is a carbonyl group or a sulfonyl group;B is either one of the formulas: ##STR2## (in which E is a methylene group, an ethylene group or an oxygen atom and a full line accompanying a broken line ( ) indicates a single bond or a double bond), ##STR3## (in which F is a methylene group or an ethylene group and a full line accompanying a broken line ( ) is as defined above) and ##STR4## (in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each a hydrogen atom or a methyl group) when A represents a carbonyl group, or B is a 1,2-phenylene group when A represents a sulfonyl group;D is an ethylene group, an ethenylene group or an ethynylene group, of which one or more may be optionally substituted with hydroxyl; andn is an integer of 0, 1 or 2, or its acid addition salt. These compounds are useful for the treatment or psychosis.

摘要翻译： 下式的化合物：其中A是羰基或磺酰基; B是下列公式之一：（其中E是亚甲基，亚乙基或氧原子，伴随虚线的全部线表示单键或双键）， （其中F是亚甲基或亚乙基，虚线（）的全部线如上所定义）和（其中R 1，R 2，R 3，R 4，R 5和R 6各自为氢原子 或甲基），当A表示羰基时，或B表示1,2-亚苯基，当A表示磺酰基时; D是亚乙基，亚乙烯基或亚乙炔基，其中一个或多个可以任选被羟基取代; n为0,1或2的整数，或其酸加成盐。 这些化合物可用于治疗或精神病。

公开(公告)号：US4598078A

公开(公告)日：1986-07-01

申请号：US543496

申请日：1983-10-19

申请人： Kikuo Ishizumi ,  Fujio Antoku ,  Yukio Asami

发明人： Kikuo Ishizumi ,  Fujio Antoku ,  Yukio Asami

IPC分类号： A61K31/495 ,  A61K31/505 ,  A61P25/20 ,  C07C51/567 ,  C07C61/09 ,  C07C61/24 ,  C07D209/48 ,  C07D239/42 ,  C07D295/073 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D403/04

CPC分类号： C07D209/48 ,  C07C51/567 ,  C07C61/09 ,  C07C61/24 ,  C07D239/42 ,  C07D295/073 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14

摘要： A succinimide derivative of the formula: ##STR1## wherein A is straight or branched C.sub.2 -C.sub.6 alkylene or alkenylene, B is straight or branched C.sub.3 -C.sub.5 alkylene, D is straight or branched C.sub.2 -C.sub.3 alkylene, E is straight or branched C.sub.2 -C.sub.3 alkylene, R.sup.1 and R.sup.2 are each hydrogen or C.sub.1 -C.sub.4 alkyl, or they may form a single bond and R.sup.3 is a phenyl group optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen and/or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: ##STR2## (in which R.sup.4 is hydrogen or phenyl), a group of the formula: CO--R.sup.5 (in which R.sup.5 is adamantyl or furyl) or hydroxy (C.sub.2 -C.sub.4) alkyl, and an acid addition salt thereof, which are useful as anti-anxiety drugs and/or anti-allergic drugs.

摘要翻译： 下式的琥珀酰亚胺衍生物，其中A是直链或支链C 2 -C 6亚烷基或亚烯基，B是直链或支链C 3 -C 5亚烷基，D是直链或支链C 2 -C 3亚烷基，E是直链或支链C 2 -C 6亚烷基， C 3亚烷基，R 1和R 2各自为氢或C 1 -C 4烷基，或者它们可以形成单键，并且R 3是任选被C 1 -C 4烷基，C 1 -C 4烷氧基，卤素和/或三氟甲基取代的苯基， 任选被卤素取代的吡啶基，任选被卤素取代的2-嘧啶基，下式的基团：其中R 4是氢或苯基，其中R 5是 金刚烷基或呋喃基）或羟基（C 2 -C 4）烷基及其酸加成盐，其可用作抗焦虑药物和/或抗过敏药物。

公开(公告)号：US4507303A

公开(公告)日：1985-03-26

申请号：US446047

申请日：1982-12-01

申请人： Kikuo Ishizumi ,  Fujio Antoku ,  Yukio Asami

发明人： Kikuo Ishizumi ,  Fujio Antoku ,  Yukio Asami

IPC分类号： A61K31/40 ,  A61K31/505 ,  C07D209/76 ,  C07D401/12 ,  C07D403/02 ,  C07D403/06 ,  C07D403/12 ,  C07D491/18 ,  C07D403/04 ,  C07D403/14

CPC分类号： C07D401/12 ,  C07D209/76 ,  C07D403/12

摘要： Succinimide derivatives representable by the following formula: ##STR1## wherein X and Y are combined to form a group of the formula: ##STR2## (wherein A is an oxygen atom, a methylene group or an ethylene group and a full line accompanying a broken line ( ) is a single bond or a double bond) and Z is a hydrogen atom or, X and Z are combined to form a group of the formula: ##STR3## (wherein A and a full line are each as defined above) and Y is a hydrogen atom, R is a phenyl group, optionally substituted with halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, a 2-pyridyl group or a 2-pyrimidinyl group and n is an integer of 3 or 4, and pharmaceutically acceptable acid addition salts thereof, which are useful as antianxious substances.

摘要翻译： 可以由下式表示的琥珀酰亚胺衍生物：其中X和Y组合形成下式的基团：其中A是氧原子，亚甲基或亚乙基和全数 伴随虚线（）是单键或双键），Z是氢原子，或X和Z组合形成下式的基团：其中A和全部线各自如所定义 并且Y是氢原子，R是任选被卤素，C 1 -C 4烷基，C 1 -C 4烷氧基或三氟甲基取代的苯基，2-吡啶基或2-嘧啶基，n是3的整数 或4及其药学上可接受的酸加成盐，其可用作抗毒物质。