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    1-aza-bicyclo[3.3.1]nonanes
    13.
    发明授权
    1-aza-bicyclo[3.3.1]nonanes 有权
    1-氮杂 - 双环[3.3.1]壬烷

    公开(公告)号：US09475811B2

    公开(公告)日：2016-10-25

    申请号：US14558776

    申请日：2014-12-03

    Applicant: NOVARTIS AG

    Inventor： Dominik Feuerbach ,  Werner Müller ,  Bernard Lucien Roy ,  Thomas Troxler ,  Konstanze Hurth ,  Mathias Frederiksen

    IPC: C07D471/08

    CPC classification number: C07D471/08

    Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I); wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them. Formula (I), wherein A represents O or N(R1); Y represents a group of formula, or wherein the left bond is attached to the A group and the right bond is attached to the R group; R represents a substituted or unsubstituted C5-C10aryl, substituted or unsubstituted hetero-C5-C10aryl, a group N(R1)(R4), or a group N(R2)(CHP3R4); R represent a hydrogen, C1-C4alkyl, or CF3; R2 represents hydrogen, C1-C4alkyl, or CF3; R3 represents hydrogen, C1-C4alkyl, or CF3; R4 represents a substituted or unsubstituted C5-C10 aryl or a substituted or unsubstituted C5-C10heteroaryl; in free base or acid addition salt form.

    AZA-BICYLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS
    14.
    发明申请
    AZA-BICYLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS 有权
    AZA-BICYLOALKYL ETHERS及其作为ALPHA7-NACHR AGONISTS的用途

    公开(公告)号：US20150183794A1

    公开(公告)日：2015-07-02

    申请号：US14643275

    申请日：2015-03-10

    Applicant: Novartis AG

    Inventor： Dominik Feuerbach ,  Konstanze Hurth ,  Timothy John Ritchie ,  Rochdi Bouhelal

    IPC: C07D487/08 ,  C07D453/02

    CPC classification number: A61K31/439 ,  A61K9/20 ,  A61K31/444 ,  C07D453/02 ,  C07D487/08

    Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

    Abstract translation: 本发明涉及式I的1-氮杂 - 双环烷基衍生物，其中X是CH 2或单键; Y是一组式，其中R具有本说明书中定义的含义，该化合物是α7烟碱型乙酰胆碱受体（nAChR）激动剂; 其制备方法，它们作为药物的用途以及包含它们的药物组合物。

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