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公开(公告)号：US20110263658A1
公开(公告)日：2011-10-27
申请号：US12674040
申请日：2008-08-18
申请人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
发明人： Helene Juteau , Michel Gallant , Daniel Dube , Patrick Roy , Renee Aspiotis , Rejean Fortin , Patrick Lacombe , Daniel McKay , Tom Yao-Hsiang Wu
IPC分类号： A61K31/4412 , A61K31/135 , C07C229/34 , A61K31/216 , C07D213/38 , A61K31/4418 , C07C255/43 , A61K31/277 , C07C271/12 , A61K31/27 , C07C237/20 , A61K31/165 , C07D211/76 , A61P9/12 , A61P13/12 , A61P9/00 , A61P3/10 , A61P27/06 , A61P15/10 , A61P25/22 , A61P25/28 , C07C211/01
CPC分类号： C07C217/62 , C07C217/48 , C07C229/38 , C07C237/10 , C07C237/20 , C07C255/43 , C07C271/12 , C07C323/32 , C07D213/38 , C07D213/64 , C07D213/89 , C07D317/60
摘要： The present invention relates to biphenyl-based renin inhibitor compounds having amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有氨基末端基团的联苯基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US07482456B2
公开(公告)日：2009-01-27
申请号：US10554176
申请日：2004-04-27
申请人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Denis Deschenes , Dwight Macdonald
发明人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Denis Deschenes , Dwight Macdonald
IPC分类号： C07D215/38
CPC分类号： C07D401/10 , C07D215/12 , C07D215/14 , C07D401/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Novel substituted 8-phenylquinolines represented by Formula (I), wherein the phenyl group at the 8-position contains an aryl or heteroaryl substituent in the meta position, are PDE4 inhibitors.
摘要翻译： 由式（I）表示的新型取代的8-苯基喹啉，其中8位上的苯基在间位含有芳基或杂芳基取代基是PDE4抑制剂。
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13.发明授权4-Oxo-1-3-substituted phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors 失效4-氧代-1,3-取代的苯基-1,4-二氢-1,8-二氮杂萘-3-甲酰胺磷酸二酯酶-4抑制剂公开(公告)号：US07342024B2
公开(公告)日：2008-03-11
申请号：US10534582
申请日：2003-11-19
申请人： Daniel Dube , Michel Gallant , Patrick Lacombe , Renee Aspiotis , Laurence Dube , Yves Girard , Dwight Macdonald
发明人： Daniel Dube , Michel Gallant , Patrick Lacombe , Renee Aspiotis , Laurence Dube , Yves Girard , Dwight Macdonald
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt thereof, are phosphodiesterase 4 inhibitors useful in the treatment of asthma and inflammation and useful for the enhancement of cognition
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是可用于治疗哮喘和炎症并且可用于增强认知的磷酸二酯酶4抑制剂
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14.发明授权4-oxo-1-(3-substituted phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors 失效4-氧代-1-（3-取代苯基-1,4-二氢-1,8-二氮杂萘-3-甲酰胺磷酸二酯酶-4抑制剂公开(公告)号：US07238706B2
公开(公告)日：2007-07-03
申请号：US10764229
申请日：2004-01-23
申请人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Renee Aspiotis , Yves Girard , Dwight Macdonald
发明人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Renee Aspiotis , Yves Girard , Dwight Macdonald
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt thereof, are phosphodiesterrase 4 inhibitors useful in the treatment of asthma and inflammation and useful for the enhancement of cognition.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是可用于治疗哮喘和炎症并且可用于增强认知的磷酸二酯酶4抑制剂。
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15.发明申请4-Oxo-1-(3-substituted phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors 失效4-氧代-1-（3-取代苯基-1,4-二氢-1,8-二氮杂萘-3-甲酰胺磷酸二酯酶-4抑制剂公开(公告)号：US20050107402A1
公开(公告)日：2005-05-19
申请号：US10764229
申请日：2004-01-23
申请人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Renee Aspiotis , Yves Girard , Dwight Macdonald
发明人： Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Renee Aspiotis , Yves Girard , Dwight Macdonald
IPC分类号： A61K31/4375 , A61K31/4745 , A61K31/506 , A61P25/00 , C07D221/00 , C07D471/02 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt thereof, are phosphodiesterrase 4 inhibitors useful in the treatment of asthma and inflammation and useful for the enhancement of cognition.
摘要翻译： 由式（I）表示的化合物或其药学上可接受的盐是可用于治疗哮喘和炎症并且可用于增强认知的磷酸二酯酶4抑制剂。
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公开(公告)号：US06812346B2
公开(公告)日：2004-11-02
申请号：US10395788
申请日：2003-03-24
申请人： Daniel Dube , Rejean Fortin , Richard Friesen
发明人： Daniel Dube , Rejean Fortin , Richard Friesen
IPC分类号： C07D21322
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用。本发明还包括 用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US6001843A
公开(公告)日：1999-12-14
申请号：US181887
申请日：1998-10-29
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89 , A61K31/535 , C07D211/70 , C07D211/72 , C07D211/78
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US08063105B2
公开(公告)日：2011-11-22
申请号：US11988437
申请日：2006-07-20
申请人： Christopher I. Bayly , Austin C. Chen , Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Dwight MacDonald , Daniel McKay , David A. Powell , Erich L. Grimm
发明人： Christopher I. Bayly , Austin C. Chen , Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Dwight MacDonald , Daniel McKay , David A. Powell , Erich L. Grimm
IPC分类号： A61K31/165 , C07C229/00 , C07C233/00
CPC分类号： C07C317/28 , C07C269/06 , C07C317/18 , C07C317/22 , C07C323/12 , C07C2601/02 , C07C2601/04 , C07D207/27 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/64 , C07D215/12 , C07D401/06 , C07C271/22
摘要： The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及通式（I）的新型肾素抑制剂及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法的相关方面。 这些新型肾素抑制剂用于治疗心血管事件和肾功能不全。
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公开(公告)号：US20100249163A1
公开(公告)日：2010-09-30
申请号：US12746037
申请日：2008-11-26
申请人： Daniel Dube , Erich L. Grimm , Dwight MacDonald , Bruce MacKay
发明人： Daniel Dube , Erich L. Grimm , Dwight MacDonald , Bruce MacKay
IPC分类号： A61K31/513 , A61K31/4545 , A61K31/454 , A61K31/451 , C07D401/04 , C07D417/04 , C07D211/52 , A61P9/10 , A61P27/06 , A61P9/04 , A61P5/42 , A61P13/12 , A61P9/12 , A61P15/10 , A61P25/22
CPC分类号： C07D211/60 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D417/04
摘要： The present invention relates to piperidinyl-based renin inhibitor compounds having the formula containing amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有含有氨基末端基团的式的哌啶基肾素抑制剂化合物及其在治疗心血管事件和肾功能不全中的用途。
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公开(公告)号：US07144896B2
公开(公告)日：2006-12-05
申请号：US10508261
申请日：2003-03-17
申请人： Michel Gallant , Denis Deschenes , Daniel Dube , Laurence Dube , Patrick Lacombe , Dwight MacDonald
发明人： Michel Gallant , Denis Deschenes , Daniel Dube , Laurence Dube , Patrick Lacombe , Dwight MacDonald
IPC分类号： C07D215/04 , A61K31/47
CPC分类号： C07D215/04 , C07D215/12 , C07D215/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04
摘要： 8-arylquinolines wherein the aryl group at the 8-position contains a meta one or two atom bridge to a phenyl, 5 or 6 member heteroaryl or fused bicyclic heteroaryl group, and wherein at least one of the bridge atoms is not carbon, are PDE4 inhibitors.
摘要翻译： 8-芳基喹啉，其中8-位上的芳基含有与苯基，5或6元杂芳基或稠合双环杂芳基相连的一个或两个原子桥，并且其中至少一个桥原子不是碳，是PDE4 抑制剂。
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