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公开(公告)号：US07060715B2
公开(公告)日：2006-06-13
申请号：US10916097
申请日：2004-08-11
IPC分类号： C07D213/22 , C07D211/72 , A61K31/435 , A61K31/44
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US06596736B2
公开(公告)日：2003-07-22
申请号：US10021187
申请日：2001-10-30
IPC分类号： A61K3144
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用。本发明还包括 用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US6071936A
公开(公告)日：2000-06-06
申请号：US312790
申请日：1999-05-17
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US5861419A
公开(公告)日：1999-01-19
申请号：US893395
申请日：1997-07-11
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新型化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无效治疗有效量的式I化合物的患者给药。图像I 本发明还包括用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US6001843A
公开(公告)日：1999-12-14
申请号：US181887
申请日：1998-10-29
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89 , A61K31/535 , C07D211/70 , C07D211/72 , C07D211/78
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
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公开(公告)号：US20050009875A1
公开(公告)日：2005-01-13
申请号：US10916097
申请日：2004-08-11
申请人： Daniel Dube , Rejean Fortin , Richard Friesen , Zhaoyin Wang , Jacques Gauthier
发明人： Daniel Dube , Rejean Fortin , Richard Friesen , Zhaoyin Wang , Jacques Gauthier
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用本发明还包括 用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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公开(公告)号：US6046217A
公开(公告)日：2000-04-04
申请号：US151626
申请日：1998-09-11
申请人： Richard Friesen , Rejean Fortin , Daniel Dube , Denis Deschenes
发明人： Richard Friesen , Rejean Fortin , Daniel Dube , Denis Deschenes
IPC分类号： C07D213/61 , C07D213/64 , C07D213/70 , A61K213/22 , C07D31/44
CPC分类号： C07D213/64 , C07D213/61 , C07D213/70
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗环加氧酶-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用本发明还包括 用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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公开(公告)号：US5817700A
公开(公告)日：1998-10-06
申请号：US814388
申请日：1997-03-11
申请人： Daniel Dube , Rejean Fortin , Richard Frenette , Richard Friesen , Daniel Guay , Sylvie Prescott
发明人： Daniel Dube , Rejean Fortin , Richard Frenette , Richard Friesen , Daniel Guay , Sylvie Prescott
IPC分类号： C07C311/16 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/44 , C07C321/28 , C07C323/22 , C07C323/62 , C07D333/22 , A61K31/10 , C07C317/10
CPC分类号： C07C311/16 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/44 , C07C321/28 , C07C323/22 , C07C323/62 , C07D333/22
摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。 本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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公开(公告)号：US06812346B2
公开(公告)日：2004-11-02
申请号：US10395788
申请日：2003-03-24
申请人： Daniel Dube , Rejean Fortin , Richard Friesen
发明人： Daniel Dube , Rejean Fortin , Richard Friesen
IPC分类号： C07D21322
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用。本发明还包括 用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。
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10.发明授权
公开(公告)号：US5428060A
公开(公告)日：1995-06-27
申请号：US936809
申请日：1992-08-27
申请人： Yves Ducharme , John W. Gillard , Rejean Fortin , Daniel Dube , Yves Girard , Pierre Hamel , Daniel Delorme
发明人： Yves Ducharme , John W. Gillard , Rejean Fortin , Daniel Dube , Yves Girard , Pierre Hamel , Daniel Delorme
IPC分类号： C07D405/14 , C07D407/14 , C07D409/14 , C07D493/08 , A61K31/36 , A61K31/365
CPC分类号： C07D405/14 , C07D407/14 , C07D409/14 , C07D493/08
摘要： Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
摘要翻译： 具有式I的化合物：I是抑制白三烯生物合成。 这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。 它们也可用于治疗心绞痛，脑痉挛，肾小球性肾炎，肝炎，内毒素血症，葡萄膜炎和同种异体移植物排斥和预防动脉粥样硬化斑块的形成。
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