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1.发明授权公开(公告)号：US06699856B2
公开(公告)日：2004-03-02
申请号：US10202817
申请日：2002-07-25
申请人： Yongxin Han , Andre Giroux , Robert Zamboni , Daniel J. McKay , Christopher I. Bayly , Erich L. Grimm , John Colucci
发明人： Yongxin Han , Andre Giroux , Robert Zamboni , Daniel J. McKay , Christopher I. Bayly , Erich L. Grimm , John Colucci
IPC分类号： A61K314965
CPC分类号： C07D403/12 , C07D241/20 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters, N-oxides and hydrates thereof are disclosed. Pharmaceutical compositions and methods of use are also included. The compounds are active against the caspase-3 enzyme, and thus are useful to treat caspase-3 mediated diseases and conditions.
摘要翻译： 公开了由式I表示的化合物及其药学上可接受的盐，酯，N-氧化物和水合物。 还包括药物组合物和使用方法。 这些化合物对半胱天冬酶-3酶具有活性，因此可用于治疗半胱天冬酶-3介导的疾病和病症。
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公开(公告)号：US20120046293A1
公开(公告)日：2012-02-23
申请号：US13269882
申请日：2011-10-10
申请人： CHRISTOPHER I. BAYLY , Austin C. Chen , Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Dwight MacDonald , Daniel McKay , David A. Powell , Erich L. Grimm
发明人： CHRISTOPHER I. BAYLY , Austin C. Chen , Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Dwight MacDonald , Daniel McKay , David A. Powell , Erich L. Grimm
IPC分类号： A61K31/165 , C07D295/192 , A61K31/5375 , A61K31/196 , A61K31/216 , C07D213/56 , A61K31/4425 , A61K31/4402 , C07C271/48 , A61K31/27 , A61K31/495 , C07D295/205 , C07C237/20 , A61P9/12 , A61P9/00 , A61P9/10 , A61P27/06 , A61P25/00 , A61P25/22 , A61P15/10 , C07C235/36
CPC分类号： C07C317/28 , C07C269/06 , C07C317/18 , C07C317/22 , C07C323/12 , C07C2601/02 , C07C2601/04 , C07D207/27 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/64 , C07D215/12 , C07D401/06 , C07C271/22
摘要： The present invention relates to renin inhibitor compounds having the structure and their use in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及具有结构和用于治疗心血管事件和肾功能不全的肾素抑制剂化合物。
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公开(公告)号：US07973037B2
公开(公告)日：2011-07-05
申请号：US12082104
申请日：2008-04-08
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/535 , A61K31/497 , A61K31/435 , A61K31/385 , C07D265/30 , C07D241/04 , C07D211/08 , C07D333/02 , C07D255/03
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如 骨质疏松症
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公开(公告)号：US07375134B2
公开(公告)日：2008-05-20
申请号：US10505796
申请日：2003-02-28
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien
IPC分类号： A01N37/34
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
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公开(公告)号：US08318748B2
公开(公告)日：2012-11-27
申请号：US13115462
申请日：2011-05-25
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/4965 , A61K31/66 , A61K31/44 , A61K31/445 , A61K31/425 , A61K31/415
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如 骨质疏松症
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公开(公告)号：US08063105B2
公开(公告)日：2011-11-22
申请号：US11988437
申请日：2006-07-20
申请人： Christopher I. Bayly , Austin C. Chen , Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Dwight MacDonald , Daniel McKay , David A. Powell , Erich L. Grimm
发明人： Christopher I. Bayly , Austin C. Chen , Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Dwight MacDonald , Daniel McKay , David A. Powell , Erich L. Grimm
IPC分类号： A61K31/165 , C07C229/00 , C07C233/00
CPC分类号： C07C317/28 , C07C269/06 , C07C317/18 , C07C317/22 , C07C323/12 , C07C2601/02 , C07C2601/04 , C07D207/27 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/64 , C07D215/12 , C07D401/06 , C07C271/22
摘要： The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及通式（I）的新型肾素抑制剂及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法的相关方面。 这些新型肾素抑制剂用于治疗心血管事件和肾功能不全。
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公开(公告)号：US20080188529A1
公开(公告)日：2008-08-07
申请号：US12082104
申请日：2008-04-08
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/4418 , C07C233/40 , A61K31/165 , C07D213/57
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如 骨质疏松症
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8.发明授权
公开(公告)号：US5994379A
公开(公告)日：1999-11-30
申请号：US246925
申请日：1999-02-09
申请人： Christopher I. Bayly , Cameron Black , Nathalie Ouimet , David Percival , Serge Leger , Marc Ouellet
发明人： Christopher I. Bayly , Cameron Black , Nathalie Ouimet , David Percival , Serge Leger , Marc Ouellet
IPC分类号： C07D333/60 , A61K31/192 , A61K31/216 , A61K31/34 , A61K31/343 , A61K31/381 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/495 , A61K31/496 , A61K31/4985 , A61P1/00 , A61P3/10 , A61P11/06 , A61P15/06 , A61P19/02 , A61P19/06 , A61P19/10 , A61P25/04 , A61P25/06 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/12 , A61P35/00 , A61P35/04 , A61P37/02 , A61P43/00 , C07C57/42 , C07C59/64 , C07C69/618 , C07C69/734 , C07C323/62 , C07D209/08 , C07D209/18 , C07D209/44 , C07D213/55 , C07D213/64 , C07D213/69 , C07D235/08 , C07D263/56 , C07D277/64 , C07D307/79 , C07D333/54 , C07D471/04 , A61K31/425 , A61K31/19 , A61K31/215 , A61K31/38 , A61K31/42 , C07C57/38 , C07C321/28 , C07D235/06
CPC分类号： C07D213/64 , C07C323/62 , C07C57/42 , C07C59/64 , C07C69/618 , C07C69/734 , C07D209/08 , C07D209/44 , C07D213/55 , C07D213/69 , C07D235/08 , C07D263/56 , C07D277/64 , C07D307/79 , C07D333/54 , C07D471/04
摘要： The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically acceptable salts and esters thereof.
摘要翻译： 本发明涉及COX-2抑制剂，其含有这些化合物和使用方法的组合物。 化合物由式I表示，并且包括其药学上可接受的盐和酯。
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公开(公告)号：US20110230446A1
公开(公告)日：2011-09-22
申请号：US13115462
申请日：2011-05-25
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Chirstophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Chirstophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/277 , A61K31/495 , A61K31/4418 , A61K31/426 , A61K31/4174 , A61K31/663 , A61P19/08 , A61P19/10 , A61P1/02 , A61P19/02 , A61P35/00 , A61P19/00
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如 骨质疏松症
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公开(公告)号：US20090281103A1
公开(公告)日：2009-11-12
申请号：US11988437
申请日：2006-07-20
申请人： Christopher I. Bayly , Austin C. Chen , Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Dwight MacDonald , Daniel McKay , David A. Powell , Erich L. Grimm
发明人： Christopher I. Bayly , Austin C. Chen , Daniel Dube , Laurence Dube , Michel Gallant , Patrick Lacombe , Dwight MacDonald , Daniel McKay , David A. Powell , Erich L. Grimm
IPC分类号： A61K31/165 , C07C237/20 , C07D215/12 , C07D213/56 , C07D295/18 , A61K31/47 , A61K31/216 , A61K31/4402 , A61K31/5375 , A61P9/00 , A61P25/00
CPC分类号： C07C317/28 , C07C269/06 , C07C317/18 , C07C317/22 , C07C323/12 , C07C2601/02 , C07C2601/04 , C07D207/27 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/64 , C07D215/12 , C07D401/06 , C07C271/22
摘要： The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency.
摘要翻译： 本发明涉及通式（I）的新型肾素抑制剂及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法的相关方面。 这些新型肾素抑制剂用于治疗心血管事件和肾功能不全。
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