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11.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer 有权核苷酸和氨基酸序列，以及其用于诊断卵巢癌的测定和方法公开(公告)号：US07906635B2
公开(公告)日：2011-03-15
申请号：US12354641
申请日：2009-01-15
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/156 , Y10T436/143333
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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12.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 失效核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US07714100B2
公开(公告)日：2010-05-11
申请号：US11978203
申请日：2007-10-29
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
IPC分类号： A61K38/00
CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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13.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer 失效新型核苷酸和氨基酸序列，以及其用于诊断肺癌的测定和方法公开(公告)号：US20060046257A1
公开(公告)日：2006-03-02
申请号：US11051720
申请日：2005-01-27
申请人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
发明人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
IPC分类号： C12Q1/68
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/112
摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。
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14.发明申请公开(公告)号：US20060040278A1
公开(公告)日：2006-02-23
申请号：US11050857
申请日：2005-01-27
申请人： Gad Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
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15.发明申请NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS OF BREAST CANCER 审中-公开新型核酸和氨基酸序列及其用于诊断乳腺癌的测定及其使用方法公开(公告)号：US20090286957A1
公开(公告)日：2009-11-19
申请号：US12350814
申请日：2009-01-08
申请人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tavor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar
发明人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tavor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar
IPC分类号： C07K14/435
CPC分类号： G01N33/57415 , C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
摘要翻译： 乳腺癌的新型标记物既敏感又准确。 这些标志物在乳腺癌中特异性地过表达，与正常的乳腺组织相反。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与乳腺癌的可能诊断相关的信息。 本发明的标记物单独或组合显示乳腺癌与非癌状态之间的高度差异检测。
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16.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer 有权核苷酸和氨基酸序列，以及其用于诊断前列腺癌的测定和方法公开(公告)号：US07368548B2
公开(公告)日：2008-05-06
申请号：US11043806
申请日：2005-01-27
申请人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotem Sorek , Michal Ayalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
发明人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotem Sorek , Michal Ayalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
CPC分类号： C07K14/705 , C07K14/47 , C07K14/82 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57434
摘要： Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of prostate cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between prostate cancer and non-cancerous states.
摘要翻译： 前列腺癌的新型标记既灵敏又准确。 此外，这些标记能够区分前列腺癌和良性前列腺增生（“BPH”）。 与正常的前列腺组织和/或BPH相反，这些标记物在前列腺癌中过度表达。 这些标记物在患者样品中单独或组合的测量提供了诊断者可以与前列腺癌的可能诊断相关的信息。 本发明的标记物单独或组合显示前列腺癌与非癌状态之间的高度差异检测。
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17.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer 审中-公开新型核苷酸和氨基酸序列，以及其用于诊断前列腺癌的测定和方法公开(公告)号：US20080014590A1
公开(公告)日：2008-01-17
申请号：US11812518
申请日：2007-06-19
申请人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotern Sorek , Michal Avalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
发明人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotern Sorek , Michal Avalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
IPC分类号： G01N33/574 , C07H21/04 , C07K14/82 , C07K16/30 , C12Q1/68
摘要： Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of prostate cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between prostate cancer and non-cancerous states.
摘要翻译： 前列腺癌的新型标记既灵敏又准确。 此外，这些标记能够区分前列腺癌和良性前列腺增生（“BPH”）。 与正常的前列腺组织和/或BPH相反，这些标记物在前列腺癌中过度表达。 这些标记物在患者样品中单独或组合的测量提供了诊断者可以与前列腺癌的可能诊断相关的信息。 本发明的标记物单独或组合显示前列腺癌与非癌状态之间的高度差异检测。
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18.发明申请Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Cardiac Disease 审中-公开新型核苷酸和氨基酸序列及其用于诊断心脏病的测定及方法公开(公告)号：US20100248270A1
公开(公告)日：2010-09-30
申请号：US12623957
申请日：2009-11-23
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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19.发明申请Novel Nucleotide and Amino Acid Sequences, and Assays and Methods of Use Thereof for Diagnosis of Lung Cancer 审中-公开新型核苷酸和氨基酸序列及其用于肺癌诊断的方法及方法公开(公告)号：US20100068736A1
公开(公告)日：2010-03-18
申请号：US12557253
申请日：2009-09-10
申请人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
发明人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
IPC分类号： G01N33/53 , C07K2/00 , C07K16/00 , G01N33/574
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。
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20.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer 失效核苷酸和氨基酸序列，以及其用于诊断肺癌的测定和方法公开(公告)号：US07667001B1
公开(公告)日：2010-02-23
申请号：US11978554
申请日：2007-10-30
申请人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Avalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
发明人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad S. Cojocaru , Michal Avalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
IPC分类号： C07K16/00
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。
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