公开(公告)号：US20190189417A1

公开(公告)日：2019-06-20

申请号：US16147683

申请日：2018-09-29

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Heather Gamble ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/14 ,  H01J49/04 ,  G01N30/72

CPC classification number: H01J49/147 ,  G01N30/7206 ,  H01J27/205 ,  H01J49/0422 ,  H01J49/145

Abstract: An ion source comprising a chamber and an electron collector is described. In one configuration, the chamber comprises a sample inlet and an ion outlet. The chamber may also include an electron inlet configured to receive electrons from an electron source. The electron collector can be arranged in opposition to the electron inlet. The chamber can be configured to direct an electron beam from the electron source along a path with the chamber transverse to a path between the gas inlet and the ion outlet. The chamber may comprise an ion guide that includes a guide axis offset from an axis of the ion outlet.

公开(公告)号：US11705319B2

公开(公告)日：2023-07-18

申请号：US17340041

申请日：2021-06-06

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Mehrnaz Sarrafzadeh ,  Gholamreza Javahery ,  Charles Jolliffe ,  Lisa Cousins

IPC: H01J49/12 ,  H01J49/10 ,  H01J37/32

CPC classification number: H01J49/123 ,  H01J37/32009 ,  H01J49/107

Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.

公开(公告)号：US20220102130A1

公开(公告)日：2022-03-31

申请号：US17340041

申请日：2021-06-06

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Mehrnaz Sarrafzadeh ,  Gholamreza Javahery ,  Charles Jolliffe ,  Lisa Cousins

IPC: H01J49/12 ,  H01J27/10 ,  H01J37/32

Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.

公开(公告)号：US20200350150A1

公开(公告)日：2020-11-05

申请号：US16869115

申请日：2020-05-07

Applicant: PERKINELMER HEALTH SCIENCES CANADA INC

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/04 ,  H01J49/26

Abstract: A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.

公开(公告)号：US20190341241A1

公开(公告)日：2019-11-07

申请号：US15970517

申请日：2018-05-03

Applicant: Perkinelmer Health Sciences Canada Inc.

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/16 ,  H01J49/06 ,  H01J49/42

Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.