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公开(公告)号：US06660286B1
公开(公告)日：2003-12-09
申请号：US09317499
申请日：1999-05-24
IPC分类号： A01K9107
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/1075 , A61K9/4858 , Y10S514/938 , Y10S514/975 , Y10S977/775 , Y10S977/801 , Y10S977/907 , Y10S977/915
摘要： An emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.
摘要翻译： 公开了一种包含共溶剂并通过生物相容性表面活性剂稳定化的生育酚乳剂作为治疗药物的载体或载体，其基本上不含有乙醇，并且可通过各种途径施用于动物或人类。 乳液中还包含聚乙二醇化维生素E.聚乙二醇化α-生育酚包括在维生素E的环羟基处由琥珀酸二酯连接的聚乙二醇亚单位，并且用作α-生育酚乳液中的主要表面活性剂，稳定剂和第二溶剂。
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公开(公告)号：US06479540B1
公开(公告)日：2002-11-12
申请号：US09671753
申请日：2000-09-27
IPC分类号： A61K31355
CPC分类号： A61K9/0019 , A61K9/1075 , A61K47/22 , Y10S514/937 , Y10S514/938 , Y10S977/907
摘要： Tocol-based compositions of charged amphiphilic and water soluble pharmaceutically active compounds or their charged precursors are prepared by forming a tocol-soluble ion pair with an oppositely charged ion-pair forming compound capable of forming a tocol-soluble ion-pair with the active compound. Also disclosed are novel compounds tocopherolsuccinate-aspartate and tocopherolsuccinate-glutamate, which are useful as ion-pair forming compounds.
摘要翻译： 通过与能够与活性化合物形成可溶性离子对的相反电荷的离子对形成化合物形成可溶性离子对，制备带电两亲和水溶性药物活性化合物或其带电前体的基于Tocol的组合物 还公开了可用作离子对形成化合物的新型化合物生育酚琥珀酸天冬氨酸和生育酚琥珀酸谷氨酸盐。
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公开(公告)号：US10463689B2
公开(公告)日：2019-11-05
申请号：US12904791
申请日：2010-10-14
摘要： The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
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14.发明授权Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same 有权用于疏水性药物的药物递送系统及其组合物公开(公告)号：US08241664B2
公开(公告)日：2012-08-14
申请号：US11911446
申请日：2006-04-14
CPC分类号： A61K31/568 , A61K9/0053 , A61K9/06 , A61K9/1075 , A61K9/4858 , A61K31/22 , A61K31/573 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/44 , C07J1/00 , A61K2300/00
摘要： A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
摘要翻译： 提供了用于口服给药具有增强和延长的吸收和改善的药代动力学的疏水性药物的药物递送系统。 在一个实施方案中，公开了包含睾酮和睾酮酯的制剂，例如棕榈酸睾酮。 还提供了用本发明制剂治疗激素缺乏或影响男性避孕的方法。
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15.发明申请ORAL TESTOSTERONE ESTER FORMULATIONS AND METHODS OF TREATING TESTOSTERONE DEFICIENCY COMPRISING SAME 有权口服维生素E制剂和治疗包含其中的TESTOSTERONE缺陷的方法公开(公告)号：US20110251167A1
公开(公告)日：2011-10-13
申请号：US12758770
申请日：2010-04-12
IPC分类号： A61K31/568 , A61P5/26
CPC分类号： A61K31/568 , A61K9/0053 , A61K9/0095 , A61K9/107 , A61K47/12 , A61K47/44
摘要： A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
摘要翻译： 提供了十一酸睾酮的药物制剂。 还提供了用本发明制剂治疗睾酮缺乏症或其症状的方法。
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16.发明申请Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use 审中-公开病毒，细菌和真菌相互作用的层状叶绿酸盐及其使用方法公开(公告)号：US20100272769A1
公开(公告)日：2010-10-28
申请号：US12274772
申请日：2008-11-20
申请人： Jerald W. Darlington, JR. , John Hughes , Panayiotis P. Constantinides , Mingming Fang , Jason H. St. Onge
发明人： Jerald W. Darlington, JR. , John Hughes , Panayiotis P. Constantinides , Mingming Fang , Jason H. St. Onge
CPC分类号： A61K35/02 , A01N59/00 , A61K33/06 , A61K33/12 , Y02A50/463
摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses, bacteria and fungi. Accordingly, provided herein are methods of inactivating a virus, bacteria or fungus and methods of treating a viral, bacterial or fungal infection. Methods of delivering a therapeutic agent to a mammalian subject and methods of inactivating a virus in the gastrointestinal tract of an animal are also provided.
摘要翻译： 层状页硅酸盐可用于吸附和/或结合病毒，细菌和真菌，从而灭活病毒，细菌和真菌。 因此，本文提供了灭活病毒，细菌或真菌的方法以及治疗病毒，细菌或真菌感染的方法。 还提供了向哺乳动物受试者递送治疗剂的方法和在动物的胃肠道中灭活病毒的方法。
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17.发明申请CHOLESTEROL-INTERACTING LAYERED PHYLLOSILICATES AND METHODS OF REDUCING HYPERCHOLESTEREMIA IN A MAMMAL 失效胆固醇相互作用的层状物质和减少牛皮癣在哺乳动物中的方法公开(公告)号：US20080292720A1
公开(公告)日：2008-11-27
申请号：US12124748
申请日：2008-05-21
IPC分类号： A61K33/00
CPC分类号： A61K33/00 , A61K31/19 , A61K31/27 , A61K31/35 , A61K31/366 , A61K31/397 , A61K31/405 , A61K31/435 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/575 , A61K31/60 , A61K31/70 , A61K45/06 , A61K2300/00
摘要： Layered phyllosilicates are useful for adsorbing and/or binding to cholesterol and, thereby, reducing blood cholesterol in a patient. Accordingly, provided herein is a method of reducing hypercholesteremia in a mammal comprising administering to said mammal a protonated and at least partially exfoliated layered phyllosilicate material alone and in combination with other cholesterol-reducing agents in an amount effective to reduce hypercholesteremia in said mammal.
摘要翻译： 层状页硅酸盐可用于吸附和/或结合胆固醇，从而降低患者的血液胆固醇。 因此，本文提供的是减少哺乳动物的高胆固醇血症的方法，其包括向所述哺乳动物单独施用质子化和至少部分剥落的层状页硅酸盐材料，并与其它降胆固醇剂组合施用有效降低所述哺乳动物中的高胆固醇血症的量。
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公开(公告)号：US20080184618A1
公开(公告)日：2008-08-07
申请号：US11959021
申请日：2007-12-18
申请人： Jerald W. Darlington , John Hughes , Panayiotis P. Constantinides , Mingming Fang , Jason H. St. Onge
发明人： Jerald W. Darlington , John Hughes , Panayiotis P. Constantinides , Mingming Fang , Jason H. St. Onge
CPC分类号： C09C1/42 , A01N59/00 , A61K9/0014 , A61K9/0034 , A61K9/06 , A61K33/00 , A61K45/06 , A61K47/02 , C01P2004/61 , A61K2300/00
摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses. Accordingly, provided herein are methods of inactivating a virus and methods of treating a viral infection. Methods of delivering a therapeutic agent to a mammalian subject and methods of inactivating a virus in the gastrointestinal tract of an animal are also provided.
摘要翻译： 层状页硅酸盐可用于吸附和/或结合病毒，从而灭活病毒。 因此，本文提供了灭活病毒的方法和治疗病毒感染的方法。 还提供了向哺乳动物受试者递送治疗剂的方法和在动物的胃肠道中灭活病毒的方法。
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公开(公告)号：US07030155B2
公开(公告)日：2006-04-18
申请号：US10151066
申请日：2002-05-17
IPC分类号： A61K43/16
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/1075
摘要： A method of making an emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes, is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated α-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of α-tocopherol.
摘要翻译： 公开了一种生产含有助溶剂并通过生物相容性表面活性剂稳定化的生育酚乳液作为治疗药物的载体或载体的方法，所述载体或载体基本上不含有乙醇，并且可通过各种途径施用于动物或人类。 乳液中还包含聚乙二醇化维生素E.聚乙二醇化α-生育酚包括在维生素E的环羟基处由琥珀酸二酯连接的聚乙二醇亚单位，并且用作α-生育酚乳液中的主要表面活性剂，稳定剂和第二溶剂。
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公开(公告)号：US06982282B2
公开(公告)日：2006-01-03
申请号：US10151079
申请日：2002-05-17
IPC分类号： A61K31/337 , A61P35/00
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/1075 , A61K9/4858 , Y10S514/938 , Y10S514/975 , Y10S977/775 , Y10S977/801 , Y10S977/907 , Y10S977/915
摘要： An emulsion of α-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated α-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of α-tocopherol.
摘要翻译： 公开了通过生物相容性表面活性剂稳定的α-生育酚乳剂，作为治疗药物的载体或载体，其基本上不含乙醇，并且可通过各种途径施用于动物或人。 乳液中还包含聚乙二醇化维生素E.聚乙二醇化α-生育酚包括在维生素E的环羟基处由琥珀酸二酯连接的聚乙二醇亚单位，并且用作α-生育酚乳液中的主要表面活性剂，稳定剂和第二溶剂。
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