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    Crystalline Forms Of Rosuvastatin Calcium Salt
    14.
    发明申请
    Crystalline Forms Of Rosuvastatin Calcium Salt 有权
    罗苏伐他汀钙盐的结晶形式

    公开(公告)号：US20080194604A1

    公开(公告)日：2008-08-14

    申请号：US11883008

    申请日：2006-01-23

    申请人： Fritz Blatter ,  Paul Adriaan Van Der Schaaf ,  Martin Szelagiewicz

    发明人： Fritz Blatter ,  Paul Adriaan Van Der Schaaf ,  Martin Szelagiewicz

    IPC分类号： A61K31/505 ,  C07D239/42

    CPC分类号： C07D239/42

    摘要： Bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid] (also known as rosuvastatin) calcium salt and hydrates can exist in new crystal forms B and C. These crystal forms provide a higher diversity on crystalline materials to optimize manufacture, formulation and biological efficiency.

    摘要翻译： 双[（E）-7- [4-（4-氟苯基）-6-异丙基-2- [甲基（甲基磺酰基）氨基]嘧啶-5-基] - （3R，5S）-3,5-二羟基庚-6- - 烯酸]（也称为瑞舒伐他汀）钙盐和水合物可以以新的晶型B和C存在。这些晶体形式在结晶材料上提供更高的多样性以优化制造，配制和生物效率。

    Crystalline forms of rosuvastatin calcium salt
    15.
    发明授权
    Crystalline forms of rosuvastatin calcium salt 有权
    瑞舒伐他汀钙盐的结晶形式

    公开(公告)号：US07932387B2

    公开(公告)日：2011-04-26

    申请号：US11883008

    申请日：2006-01-23

    申请人： Fritz Blatter ,  Paul Adriaan Van Der Schaaf ,  Martin Szelagiewicz

    发明人： Fritz Blatter ,  Paul Adriaan Van Der Schaaf ,  Martin Szelagiewicz

    IPC分类号： C07D239/42 ,  A61K31/505 ,  A61P3/06

    CPC分类号： C07D239/42

    摘要： Bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid] (also known as rosuvastatin) calcium salt and hydrates can exist in new crystal forms B and C. These crystal forms provide a higher diversity on crystalline materials to optimize manufacture, formulation and biological efficiency.

    摘要翻译： 双[（E）-7- [4-（4-氟苯基）-6-异丙基-2- [甲基（甲基磺酰基）氨基]嘧啶-5-基] - （3R，5S）-3,5-二羟基庚-6- - 烯酸]（也称为瑞舒伐他汀）钙盐和水合物可以以新的晶型B和C存在。这些晶体形式在结晶材料上提供更高的多样性以优化制造，配制和生物效率。

    Process for the synthesis of amine ethers from secondary amino oxides
    20.
    发明授权
    Process for the synthesis of amine ethers from secondary amino oxides 有权

    公开(公告)号：US07402675B2

    公开(公告)日：2008-07-22

    申请号：US10919776

    申请日：2004-08-17

    申请人： Andreas Hafner ,  Hans Jürg Kirner ,  Franz Schwarzenbach ,  Paul Adriaan Van Der Schaaf ,  Peter Nesvadba

    发明人： Andreas Hafner ,  Hans Jürg Kirner ,  Franz Schwarzenbach ,  Paul Adriaan Van Der Schaaf ,  Peter Nesvadba

    IPC分类号： C07D211/54

    CPC分类号： C07D401/14 ,  C04B35/632 ,  C07D209/44 ,  C07D211/94 ,  C07D217/26 ,  C07D241/08 ,  C07D401/12 ,  C07D405/12 ,  C08K5/3412

    摘要： An amine ether of formula A wherein a is 1 or 2; and when a is 1, E is E′; when a is 2, E is L; E′ is C1-C36 alkyl; C3-C18 alkenyl; C2-C18 alkinyl; C5-C18 cycloalkyl; C5-C18 cycloalkenyl; a radical of a saturated or unsaturated aliphatic bicyclic or tricyclic hydrocarbon of 7 to 12 carbon atoms; C2-C7alkyl or C3-C7alkenyl substituted by halogen; C7-C15 aralkyl or C7-C15 aralkyl substituted by C1-C4 alkyl or phenyl; or E′ is a radical of formula (VII) as explained in claim 1; T′ is tertiary C4-C18alkyl or phenyl, each of which are unsubstituted or substituted by halogen, OH, COOR21 or C(O)—R22; or T′ is C5-C12cycloalkyl; C5-C12cycloalkyl which is interrupted by at least one O or —NR18—; a polycyclic alkyl radical having 7-18 carbon atoms, or the same radical which is interrupted by at least one O or —NR18—; or T′ is —C(G1)(G2)-T″; or C1-C18alkyl or C5-C12cycloalkyl substituted by T″ is hydrogen, halogen, NO2, cyano, or is a monovalent organic radical comprising 1-50 carbon atoms; or T″ and T′ together form a divalent organic linking group completing, together with the hindered amine nitrogen atom and the quaternary carbon atom substituted by G1 and G2, an optionally substituted five- or six-membered ring structure; and all other residues are as defined in claim 1, are obtained in good yield from the corresponding N-oxyl hindered amine precursor by reaction with a hydrocarbon E1-H or H-L-H in the presence of an organic hydroperoxide and a catalytic amount of copper or a copper compound. The products of present process find utility as polymerization regulators and/or light stabilizers for organic material.