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11.发明授权公开(公告)号：US07553653B2
公开(公告)日：2009-06-30
申请号：US11230374
申请日：2005-09-19
申请人： Emilio Kakkis , Daniel Oppenheimer , Paul Fitzpatrick , Robert Heft , Alejandra Gamez , Lin Wang , Woomi Kim , Mary Straub , Marianne Patch , Raymond C. Stevens
发明人： Emilio Kakkis , Daniel Oppenheimer , Paul Fitzpatrick , Robert Heft , Alejandra Gamez , Lin Wang , Woomi Kim , Mary Straub , Marianne Patch , Raymond C. Stevens
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C07K2299/00 , Y02A90/26
摘要： The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.
摘要翻译： 本发明涉及蛋白质苯丙氨酸氨裂解酶的用途，以及所述蛋白质的生物活性衍生物用于预防或治疗与人或动物体内苯丙氨酸不平衡有关的疾病。 更具体地说，本发明涉及上述分子用于预防或治疗体内苯丙氨酸失衡的治疗用途。 本发明还涉及包含药物活性量的上述治疗分子以及使用所述治疗组合物的治疗方法的治疗组合物。 最后，本发明涉及用于选择所述蛋白质的更多治疗上有效的变体以及所选择的变体本身的方法。
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公开(公告)号：US4914871A
公开(公告)日：1990-04-10
申请号：US244540
申请日：1988-09-12
申请人： Paul Fitzpatrick
发明人： Paul Fitzpatrick
IPC分类号： B24B33/02
CPC分类号： B24B33/02
摘要： Thin wall, torque sensitive pinion gears, sun gears or other such workparts are driven in rotation in a fixture during honing of the internal diameter to minimize out-of-roundness. The fixture for honing multiple workparts at a time includes a workpart driving means having multiple workpart driving gears each meshed with a respective one of the workparts. Each workpart driving gear is mounted on a hollow rotatable bushing arranged end-to-end with respect to adjacent bushings and dog-bone shaped driver members interconnect and are drivingly received in adjacent bushings. Means is connected to one of the dog-bone shaped members to rotate same and thereby cause the workpart driver gears to rotate the workparts in unison during honing.
摘要翻译： 珩磨内径时，薄壁，扭矩敏感小齿轮，太阳齿轮或其他这样的工件在固定装置中旋转地被驱动以最小化不圆度。 一次用于珩磨多个工件的夹具包括具有多个工件驱动齿轮的工件驱动装置，每个工件驱动装置与相应的一个工件啮合。 每个工件驱动齿轮安装在相对于相邻衬套端对端布置的中空可旋转衬套上，并且狗骨形的驱动器构件互连并且被驱动地容纳在相邻衬套中。 装置连接到其中一个狗骨形构件以使其旋转，从而使得工件驱动齿轮在珩磨期间一致地旋转工件。
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公开(公告)号：US4485657A
公开(公告)日：1984-12-04
申请号：US347747
申请日：1982-02-10
申请人： Robert R. Ridley , Paul Fitzpatrick
发明人： Robert R. Ridley , Paul Fitzpatrick
摘要： A tool is provided for pressure forming teeth in the periphery of a cylindrical, tubular workpiece such as a power transmission member by rolling. The tool has an improved tooth generating configuration which improves the flow characteristics of the metal in the workpiece and develops uniformity of tooth wall thickness during the tooth generating process.
摘要翻译： 提供了一种用于通过滚动在诸如动力传递构件的圆柱形管状工件的周边中压力成形齿的工具。 该工具具有改进的齿发生构造，其改善了工件中金属的流动特性，并且在牙齿产生过程中形成了牙槽壁厚度的均匀性。
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公开(公告)号：US4199903A
公开(公告)日：1980-04-29
申请号：US897626
申请日：1978-04-19
申请人： Paul Fitzpatrick
发明人： Paul Fitzpatrick
CPC分类号： B24B33/085
摘要： An abrading tool (20, 20a, 20b) is disclosed as having a tapered arbor (22) and an abrasive insert 24 including a helical element (28) with a plurality of coils (30) that receive the arbor in an axially incompressibly mounted relationship. An abrasive strip (32) of a helical shape on the coils performs a machining operation upon tool rotation. The abrasive strip on each coil is spaced from the abrasive strip on adjacent coils. Nuts (40, 44, 46) threaded on the arbor provide a means for adjustably positioning the abrasive insert axially along the arbor to control the diameter of each coil in order to initially size the insert and to subsequently compensate for wear of the abrasive strip. Different embodiments disclosed include a helical spacer (34, 36) which spaces the coils of the helical element, coils which are directly engaged with each other and define a helical groove (64) that receives a spacer (66) located between the abrasive strip on each coil, and passages (56, 58, 60, 62) through the arbor and the insert for feeding fluid to the abrasive strip.
摘要翻译： 公开了一种研磨工具（20,20a，20b）具有锥形心轴（22）和包括具有多个线圈（30）的螺旋元件（28）的研磨插入件24，所述多个线圈（30）以轴向不可压缩安装的关系 。 线圈上的螺旋状研磨条（32）在工具旋转时进行加工操作。 每个线圈上的研磨条与相邻线圈上的研磨条隔开。 在心轴上螺纹的螺母（40,44,46）提供了一种用于沿着心轴轴向地可调节地定位研磨插入件的装置，以控制每个线圈的直径，以便初始地对插入物进行尺寸并随后补偿研磨带的磨损。 所公开的不同实施例包括螺旋间隔物（34,36），其间隔螺旋形元件的线圈，线圈彼此直接接合并限定螺旋槽（64），该螺旋槽接纳位于磨料带之间的间隔物（66） 每个线圈和通过心轴的通道（56,58,60,62）和用于将流体输送到研磨带的插入件。
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公开(公告)号：US4188755A
公开(公告)日：1980-02-19
申请号：US897625
申请日：1978-04-19
申请人： Paul Fitzpatrick
发明人： Paul Fitzpatrick
CPC分类号： B24B33/08 , Y10S451/905
摘要： An expandable abrading tool (20, 20a, 20b) disclosed includes a rotatable arbor (22) and an abrasive insert (24, 24a, 24b) having stacked washers (26) which receive the arbor and are mounted thereon in a clamped relationship. Each washer has a round outer edge including an abrasive (32) secured thereto for performing a cutting operation upon tool rotation. The washers each have a frustoconical shape that points toward one axial end of the insert. A threaded clamp (38, 40, 42, 44) which provides a means for clamping the ends (34, 36) of the insert is adjustable to increase the clamping force in order to flatten the washers and thereby control the washer diameters. The insert can thus be initially sized for use and can be adjusted to compensate for wear of the abrasive. Different embodiments of the abrasive insert include the washers with slightly smaller spacers (28) interposed therebetween in an alternating relationship, the washers directly engaged with each other, and flutes (46) in the outer edges of the washers. It is preferable but not absolutely necessary that the flutes (46) be aligned in an axial relationship along the insert length. The washers are made from a suitable spring metal, preferably a copper alloy such as bronze with a component such as beryllium, so that the clamping force required to provide the flattening thereof is not too great. The flutes (46) also lessen the required clamping force to flatten the washers.
摘要翻译： 所公开的可膨胀研磨工具（20,20a，20b）包括可旋转的心轴（22）和具有堆叠的垫圈（26）的研磨插入件（24,24a，24b），其接收心轴并以夹紧的关系安装在其上。 每个垫圈具有包括固定在其上的磨料（32）的圆形外边缘，用于在工具旋转时执行切割操作。 垫圈各自具有指向插入件的一个轴向端部的截头圆锥形状。 提供用于夹紧插入件的端部（34,36）的装置的螺纹夹具（38,40,42,44）是可调节的，以增加夹紧力，以使垫圈变平，从而控制垫圈直径。 因此，插入件可以初始尺寸使用，并且可以调节以补偿研磨剂的磨损。 磨料刀片的不同实施例包括具有交替关系的介于其间的稍小的间隔件（28）的垫圈，彼此直接接合的垫圈以及垫圈的外边缘中的槽纹（46）。 优选但不是绝对必要的是，凹槽（46）沿插入件长度以轴向对准。 垫圈由合适的弹簧金属制成，优选铜合金，例如具有诸如铍的成分的青铜，使得提供其扁平化所需的夹紧力不会太大。 凹槽（46）也减小了所需的夹紧力以使垫圈变平。
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公开(公告)号：US4173852A
公开(公告)日：1979-11-13
申请号：US913612
申请日：1978-06-08
申请人： Paul Fitzpatrick
发明人： Paul Fitzpatrick
CPC分类号： B24B33/085
摘要： A rotatable cutting tool (10) of the disclosure includes an expandable cutting section (40) and a leading end having an expandable pilot (16) for properly aligning the tool during use. The trailing end of the tool preferably also has an expandable pilot (18) for aligning the tool during movement back through a bore which has been machined. A unitary body (20) of the tool has a helical slot (24) extending axially therethrough and has an inner tapered surface (26) for mounting the tool on a tapered arbor (12) such that movement therealong by nuts (34, 36, 38) engaged with axial end surfaces of the pilots controls the size of the cutting section and the pilots. The expandable tool construction is particularly adaptable for abrasion tools and is disclosed with abrasive particles (22) secured to the cutting section.
摘要翻译： 本公开的可旋转切割工具（10）包括可扩展切割部分（40）和具有可扩展引导件（16）的前端，用于在使用期间使工具正确对准。 该工具的后端优选地还具有可扩展的先导件（18），用于在通过已加工的孔的移动过程中对准该工具。 工具的整体（20）具有一个轴向延伸延伸的螺旋槽（24），并具有用于将工具安装在锥形心轴（12）上的内锥形表面（26），从而使螺母槽（34,36， 38）与飞行员的轴向端面接合，控制切割部分和飞行员的大小。 可扩展工具结构特别适用于磨损工具，并且公开了固定到切割部分的磨料颗粒（22）。
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