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    USE OF PEPTIDE LL-37 AS A THERAPEUTIC AGENT
    13.
    发明申请
    USE OF PEPTIDE LL-37 AS A THERAPEUTIC AGENT 审中-公开
    使用作为治疗药物的肽LL-37

    公开(公告)号：US20100210539A1

    公开(公告)日：2010-08-19

    申请号：US12677802

    申请日：2008-09-09

    申请人： Dorian Bevec ,  Fabio Cavalli ,  Vera Cavalli ,  Gerald Bacher

    发明人： Dorian Bevec ,  Fabio Cavalli ,  Vera Cavalli ,  Gerald Bacher

    IPC分类号： A61K38/16 ,  C07K14/00 ,  A61P35/00 ,  A61P29/00 ,  A61P25/00 ,  A61P11/00 ,  A61P9/00 ,  A61P3/00

    CPC分类号： A61K38/22 ,  A23L33/18 ,  A23L33/40 ,  A23V2002/00 ,  Y02A50/385 ,  Y02A50/402 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/423 ,  A23V2200/308 ,  A23V2200/318 ,  A23V2200/322 ,  A23V2200/324 ,  A23V2200/326 ,  A23V2250/55

    摘要： The present invention is directed to the use of the peptide compound Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

    摘要翻译： 本发明涉及肽化合物Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg- 作为预防和/或治疗癌症的治疗剂的Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2 ，自身免疫性疾病，纤维化疾病，炎症性疾病，神经变性疾病，感染性疾病，肺部疾病，心脏和血管疾病以及代谢疾病。 此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys- Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr- Glu-Ser-NH 2任选地与至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂一起。

    USE OF A PEPTIDE AS A THERAPEUTIC AGENT
    15.
    发明申请
    USE OF A PEPTIDE AS A THERAPEUTIC AGENT 审中-公开
    使用作为治疗剂的肽

    公开(公告)号：US20100204129A1

    公开(公告)日：2010-08-12

    申请号：US12677112

    申请日：2008-09-09

    申请人： Dorian Bevec ,  Fabio Cavalli ,  Vera Cavalli ,  Gerald Bacher

    发明人： Dorian Bevec ,  Fabio Cavalli ,  Vera Cavalli ,  Gerald Bacher

    IPC分类号： A61K38/16 ,  C07K19/00 ,  A61P31/06 ,  A61P35/00 ,  A61P9/00 ,  A61P11/00

    CPC分类号： A61K38/046 ,  A61K38/00 ,  C07K14/575 ,  Y02A50/387 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/406 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/423 ,  Y02A50/471 ,  Y02A50/481

    摘要： The present invention is directed to the use of the peptide compound Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases.Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

    摘要翻译： 本发明涉及肽化合物Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-D-Arg-Pro-Lys-Pro-Gln- Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2作为预防和/或治疗癌症，自身免疫性疾病，纤维化疾病，炎症性疾病，神经变性疾病，感染性疾病，肺部疾病，心脏 和血管疾病和代谢疾病。 此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu- Leu-Gly-Pro-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH 2任选与至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂 和/或稀释剂。