公开(公告)号：US09974321B2

公开(公告)日：2018-05-22

申请号：US15442574

申请日：2017-02-24

申请人： CHINA NATIONAL RESEARCH INSTITUTE OF FOOD AND FERMENTATION INDUSTRIES

发明人： Muyi Cai ,  Ruizeng Gu ,  Jun Lu ,  Tao Ma ,  Xingchang Pan ,  Zhe Dong ,  Yong Ma ,  Yaguang Xu ,  Yongqing Ma ,  Zhentao Jin ,  Liang Chen ,  Lu Lu ,  Wenying Liu ,  Ying Wei ,  Haixin Zhang ,  Yan Liu ,  Kelu Cao ,  Jing Wang ,  Guoming Li ,  Ming Zhou

IPC分类号： A23J1/04 ,  A23J3/04 ,  A23J3/34 ,  A23L33/17 ,  A23L17/20 ,  C07K14/46 ,  A23L33/18

CPC分类号： A23J1/04 ,  A23J3/04 ,  A23J3/34 ,  A23J3/341 ,  A23L17/20 ,  A23L33/17 ,  A23L33/18 ,  A23V2002/00 ,  C07K14/461 ,  A23V2200/304 ,  A23V2250/542 ,  A23V2250/55

摘要： Disclosed are a fish protein oligopeptide with low allergenicity and slight fishiness, and industrial preparation method and application thereof. The method comprises the following steps: 1) washing fresh fish flesh and/or fish wastes, crushing, and adding water to obtain a mixture; 2) performing thermal denaturation on the mixture to obtain a denaturized protein solution; 3) centrifuging the denaturized protein solution to obtain a precipitate, and adding water into the precipitate and grinding, to obtain a slurry; 4) adjusting the slurry to pH 6-9, and sequentially adding a neutral protease, a papain and an alkaline protease to conduct enzymolysis, and after enzyme inactivation, to obtain an enzymatic hydrolysate; 5) centrifuging the enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant, to obtain the fish protein oligopeptide with low allergenicity and slight fishiness. The method completely eliminates the allergenicity and fishiness of fish proteins, and prevents release of bitter components.

公开(公告)号：US09930906B1

公开(公告)日：2018-04-03

申请号：US15588224

申请日：2017-05-05

申请人： Swallow Solutions, LLC

发明人： Eric Horler ,  Jacqueline Hind ,  JoAnne Robbins ,  Elfi Anggreani ,  Marcus Brody ,  Malcond Valladares ,  Eric James

IPC分类号： A23L2/66 ,  A23L2/44 ,  A23L2/60 ,  A23L2/56 ,  A23L2/52

CPC分类号： A23L2/66 ,  A23G9/045 ,  A23L2/44 ,  A23L2/52 ,  A23L2/56 ,  A23L2/60 ,  A23V2002/00 ,  A23V2200/242 ,  A23V2200/244 ,  A23V2200/30 ,  A23V2250/032 ,  A23V2250/044 ,  A23V2250/046 ,  A23V2250/506 ,  A23V2250/54252 ,  A23V2250/55 ,  A23V2250/708

摘要： Provided herein are protein beverages. In particular, provided herein are protein beverages that are thickened, stable, and ready to drink beverages designed for consumption by subjects (e.g., subjects having a need for thickened beverages). In some embodiments, the subjects are subjects having dysphagia.

公开(公告)号：US20170319666A1

公开(公告)日：2017-11-09

申请号：US15656099

申请日：2017-07-21

申请人： MEGMILK SNOW BRAND CO., LTD.

发明人： Aiko OHMACHI ,  Hiroaki MATSUYAMA ,  Yoshikazu MORITA ,  Yuko ISHIDA ,  Takayuki NARA ,  Ken KATO ,  Atsushi SERIZAWA ,  Hiroshi UENO ,  Hiroshi URAZONO

IPC分类号： A61K38/46 ,  A23C9/152 ,  A23C9/16 ,  A61K9/16 ,  A23C9/146 ,  A61K9/00 ,  A61K38/57

CPC分类号： A61K38/465 ,  A23C9/1465 ,  A23C9/1526 ,  A23C9/16 ,  A23V2002/00 ,  A23V2200/00 ,  A61K9/0095 ,  A61K9/1682 ,  A61K38/57 ,  C12Y301/27 ,  A23V2200/306 ,  A23V2250/55

摘要： The invention relates to a powdered milk product includes angiogenin and/or angiogenin hydrolysate in an amount of 1.4 to 24 mg/15 g, and cystatin and/or cystatin hydrolysate in the mass ratio to the angiogenin and/or angiogenin hydrolysate of 0.03 to 1.3.

公开(公告)号：US09648897B2

公开(公告)日：2017-05-16

申请号：US14566363

申请日：2014-12-10

申请人： Mario Sandoval Huertas ,  Marta Miguel Castro ,  Marta Garces Rimon ,  Rosina Lopez Fandiño

发明人： Mario Sandoval Huertas ,  Marta Miguel Castro ,  Marta Garces Rimon ,  Rosina Lopez Fandiño

IPC分类号： A23J1/08 ,  A23J3/34 ,  A23L33/18 ,  A23C20/02 ,  A23G3/44 ,  A23G3/52 ,  A23P30/40 ,  A23L9/10

CPC分类号： A23J1/08 ,  A23C20/02 ,  A23G3/44 ,  A23G3/52 ,  A23J3/341 ,  A23L9/12 ,  A23L33/18 ,  A23P30/40 ,  A23V2002/00 ,  A23V2200/226 ,  A23V2250/5428 ,  A23V2250/55

摘要： The invention relates to healthy food compositions with a gel or foam texture that have antioxidant properties, are rich in proteins, low-fat, lactose- and casein-free and easy-to-chew, comprising a neutral-flavored egg hydrolysate as a basic ingredient.These compositions are presented as an alternative to sweet and salty dishes using dairy products as a base because they have similar flavor, appearance and texture characteristics. These compositions are also presented as new foods that are particularly indicated for being consumed by people who are lactose intolerant or who have obesity issues.

公开(公告)号：US09597308B2

公开(公告)日：2017-03-21

申请号：US14713830

申请日：2015-05-15

申请人： Viva Pharmaceutical, Inc.

发明人： Xueju Xie ,  Rhett Sean Daniels

IPC分类号： A61K31/315 ,  C07F15/02 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  A61K31/555

CPC分类号： A61K31/315 ,  A23L33/165 ,  A23L33/175 ,  A23L33/18 ,  A23V2002/00 ,  A61K31/555 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  C07F15/025 ,  A23V2200/30 ,  A23V2200/322 ,  A23V2200/324 ,  A23V2250/156 ,  A23V2250/1586 ,  A23V2250/1588 ,  A23V2250/1592 ,  A23V2250/1608 ,  A23V2250/161 ,  A23V2250/1612 ,  A23V2250/1626 ,  A23V2250/1642 ,  A23V2250/55

摘要： A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to zinc to form a chelate ring. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with zinc. A compound having a chelate formulation with zinc being chelated by an N-acetyl-L-cysteine ligand.

公开(公告)号：US20160375061A1

公开(公告)日：2016-12-29

申请号：US14902518

申请日：2014-07-02

申请人： INTERNATIONAL NUTRITION RESEARCH COMPANY

发明人： Claude VINCENT

IPC分类号： A61K35/20 ,  A61K31/4415 ,  A61K31/355 ,  A61K31/4375 ,  A61K31/59 ,  A61K31/202 ,  A61K38/44 ,  A61K38/06 ,  A61K33/06 ,  A61K38/19 ,  A61K31/198 ,  A61K31/405 ,  A61K31/155 ,  A61K33/30 ,  A61K33/04 ,  A61K31/366 ,  A61K31/401 ,  A61K9/00 ,  A61K38/38

CPC分类号： A61K35/20 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/175 ,  A23L33/18 ,  A23L33/19 ,  A23V2002/00 ,  A61K9/0053 ,  A61K31/155 ,  A61K31/198 ,  A61K31/202 ,  A61K31/355 ,  A61K31/366 ,  A61K31/401 ,  A61K31/405 ,  A61K31/426 ,  A61K31/4375 ,  A61K31/4415 ,  A61K31/59 ,  A61K33/04 ,  A61K33/06 ,  A61K33/30 ,  A61K38/06 ,  A61K38/08 ,  A61K38/193 ,  A61K38/38 ,  A61K38/446 ,  A61K2300/00 ,  C12Y115/01001 ,  A23V2200/326 ,  A23V2200/328 ,  A23V2250/0604 ,  A23V2250/062 ,  A23V2250/0626 ,  A23V2250/0628 ,  A23V2250/065 ,  A23V2250/1578 ,  A23V2250/187 ,  A23V2250/1882 ,  A23V2250/5424 ,  A23V2250/54242 ,  A23V2250/55 ,  A23V2250/7052 ,  A23V2250/7056 ,  A23V2250/71 ,  A23V2250/712

摘要： A composition suitable for use as a health product, including a mixture of active ingredients made up of at least: a lactoserum hydrolysate with a molecular weight between 200 and 5000 daltons, alpha-lactalbumin, at least one AMPK, MAPK, PPAR and/or SIRT1 cycle regulator, and milk calcium. The composition is particularly useful as a medical nutrition product or orally administered drug, to prevent and/or combat various diseases.

摘要翻译： 适合用作健康产品的组合物，包括由至少由分子量在200和5000道尔顿之间的乳糖水解产物，α-乳清蛋白，至少一种AMPK，MAPK，PPAR和/或 SIRT1循环调节剂和牛奶钙。 该组合物特别可用作医疗营养产品或口服药物，以预防和/或对抗各种疾病。

公开(公告)号：US20160022770A1

公开(公告)日：2016-01-28

申请号：US14872641

申请日：2015-10-01

申请人： Wisconsin Alumni Research Foundation

发明人： Denise M. Ney ,  Eric Chi-Liang Yen ,  David W. Nelson ,  Patrick Solverson

IPC分类号： A61K38/17 ,  A23L1/305 ,  A61K9/00

CPC分类号： A61K38/1709 ,  A23L33/18 ,  A23V2002/00 ,  A61K9/0053 ,  A61K38/018 ,  A61K38/22 ,  A23V2200/306 ,  A23V2200/332 ,  A23V2250/55

摘要： Methods for improving the health of a female human or non-human animal are disclosed. The methods include the step of administering to the animal compositions including an effective amount of glycomacropeptide (GMP) for effectuating the methods. Specifically, the methods can be used to increase the rate of fat metabolism or fat oxidation, decrease percentage of body fat, increase the rate of bone mineralization, increase bone mineral content, increase bone mineral density, and/or increase bone strength in the animal.GMP-containing compositions can be used according to the disclosed methods to treat obesity and related metabolic conditions, or to treat or prevent osteoporosis, osteopenia, and other conditions related to loss of bone mineral content or bone strength.

公开(公告)号：US20150337010A1

公开(公告)日：2015-11-26

申请号：US14327070

申请日：2014-07-09

申请人： Tunghai University

发明人： Wen-Dee CHIANG ,  Wan-Teng LIN

IPC分类号： C07K5/10 ,  A23L1/305

CPC分类号： C07K5/10 ,  A23L33/18 ,  A23V2002/00 ,  A61K38/07 ,  C07K5/101 ,  A23V2200/324 ,  A23V2250/55

摘要： This invention discloses an isolated peptide containing an amino acid sequence of SEQ ID No.1. The isolated peptide is capable of providing the effects in suppressing hepatocyte apoptosis, attenuating hepatic triglyceride accumulation, suppressing the expression of inflammatory cytokines, inhibiting expression of pro-apoptotic proteins, enhancing expression of survival factor and inhibiting the expression of biomarker of hepatic fibrosis. Therefore, this invention discloses the peptide as the effective ingredient in a composition for treating or preventing liver related diseases.

摘要翻译： 本发明公开了含有SEQ ID No.1的氨基酸序列的分离肽。 分离的肽能够提供抑制肝细胞凋亡，减轻肝脏甘油三酯积累，抑制炎症细胞因子表达，抑制促凋亡蛋白表达，增强生存因子表达和抑制肝纤维化生物标志物表达的作用。 因此，本发明公开了作为治疗或预防肝脏相关疾病的组合物中的有效成分的肽。

公开(公告)号：US20150265658A1

公开(公告)日：2015-09-24

申请号：US14667247

申请日：2015-03-24

申请人： The University of Tokyo ,  ALMADO Inc.

发明人： Yoriko ATOMI ,  Miho SHIMIZU ,  Yukio HASEBE

IPC分类号： A61K35/57 ,  A61Q5/08 ,  A61Q19/00 ,  A61K8/98

CPC分类号： A61K35/57 ,  A23L33/16 ,  A23L33/17 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/981 ,  A61K2800/28 ,  A61K2800/412 ,  A61Q5/08 ,  A61Q19/007 ,  A61Q19/08 ,  A23V2200/318 ,  A23V2250/1578 ,  A23V2250/20 ,  A23V2250/55

摘要： Providing an agent for activating a sirtuin gene and an application thereof. The agent for activating a sirtuin gene is characterized to contain an egg shell membrane ingredient, for example an egg shell membrane-containing powder or soluble egg shell membrane ingredient.

摘要翻译： 提供活化sirtuin基因的药剂及其应用。 用于活化sirtuin基因的试剂的特征在于含有蛋壳膜成分，例如含蛋壳膜的粉末或可溶性蛋壳膜成分。

公开(公告)号：US20150257411A1

公开(公告)日：2015-09-17

申请号：US14436108

申请日：2013-10-21

申请人： DSM IP ASSETS B.V.

发明人： Arthur Maurits Christiaan Janse ,  Cecile Veerman ,  Gerardus Johannes Franciscus Smolders

IPC分类号： A23J3/34 ,  A23J3/14 ,  C12P21/06

CPC分类号： A23J3/346 ,  A23J1/125 ,  A23J3/14 ,  A23L33/18 ,  A23V2002/00 ,  C12P21/06 ,  C12Y304/11 ,  C12Y304/21 ,  C12Y304/22 ,  C12Y304/23 ,  C12Y304/24 ,  C12Y304/24028 ,  C12Y304/25 ,  A23V2250/548 ,  A23V2250/55

摘要： The present invention provides a rice bran hydrolysate which comprises of more than 90%, preferably of more than 95%, of (poly) peptides with a molecular weight (MW) of more than 500 Da and which has a DH (Degree of Hydrolysis) of at least 10%, preferably between 10 and 16%. According to another aspect of the invention a process to produce a rice bran hydrolysate is provided.

摘要翻译： 本发明提供了一种米糠水解产物，其包含分子量（MW）大于500Da并具有DH（水解度）的多于90％，优选大于95％的（多）肽， 至少10％，优选10至16％。 根据本发明的另一方面，提供了生产米糠水解产物的方法。