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公开(公告)号：US20240299523A1
公开(公告)日：2024-09-12
申请号：US18660419
申请日：2024-05-10
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
CPC classification number: A61K39/092 , A61K39/39 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B Streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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公开(公告)号：US12016913B2
公开(公告)日：2024-06-25
申请号：US17474561
申请日：2021-09-14
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
CPC classification number: A61K39/092 , A61K39/39 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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公开(公告)号：US20230218738A1
公开(公告)日：2023-07-13
申请号：US18192352
申请日：2023-03-29
Applicant: Pfizer Inc.
Inventor： Ye Che , Philip Ralph Dormitzer , Alexey Vyacheslavovich Gribenko , Luke David Handke , Avvari Krishna Prasad , Xiayang Qiu , Mark Edward Ruppen , Xi Song , Kena Anne Swanson , Srinivas Kodali , Xin Xu , KariAnn Sweeney Efferen , Ping Cai , Kristin Rachael Tompkins , Lorna del Pilar Nunez
IPC: C07K14/005 , A61K39/155
CPC classification number: C07K14/005 , A61K39/155 , A61K2039/575
Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.
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公开(公告)号：US20230000966A1
公开(公告)日：2023-01-05
申请号：US17772610
申请日：2020-10-28
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Ye Che , Wei Chen , Laurent Oliver Chorro , Ling Chu , Robert G.K. Donald , Matthew Curtis Griffor , Jianxin Gu , Zeqiang Guan , Jin-Hwan Kim , Srinivas Kodali , Scott Ellis Lomberk , Jason Arnold Lotvin , Nishith Merchant , Justin Keith Moran , Rosalind Pan , Avvari Krishna Prasad , Mark Edward Ruppen , Suddham Singh , David Robert Stead , Karen Kiyoko Takane
IPC: A61K39/108 , C07K14/245
Abstract: In one aspect, the invention relates to a polypeptide derived from E. coli and a fragment thereof, including compositions and methods thereof. Also disclosed herein are compositions that include a polypeptide derived from E. coli and a fragment thereof; and modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. In a further aspect, disclosed herein are mammalian host cells that include sequence(s) encoding a polypeptide derived from E. coli or fragments thereof.
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公开(公告)号：US11260119B2
公开(公告)日：2022-03-01
申请号：US16534457
申请日：2019-08-07
Applicant: Pfizer Inc.
Inventor： Robert G. K. Donald , Annaliesa Sybil Anderson , Laurent Oliver Chorro , Jianxin Gu , Jin-Hwan Kim , Srinivas Kodali , Jason Arnold Lotvin , Justin Keith Moran , Rosalind Pan , Avvari Krishna Prasad , Mark Edward Ruppen , Suddham Singh , Ling Chu , Scott Ellis Lomberk , Karen Kiyoko Takane , Nishith Merchant , Wei Chen
IPC: A61K39/108 , C08B37/00 , A61P31/04 , A61P37/04 , A61K39/00
Abstract: In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
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Patent Agency Ranking
公开(公告)号：US11147865B2
公开(公告)日：2021-10-19
申请号：US16984499
申请日：2020-08-04
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B Streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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17.发明授权公开(公告)号：US11090375B2
公开(公告)日：2021-08-17
申请号：US16899738
申请日：2020-06-12
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
Abstract: The present invention relates to new immunogenic compositions comprising conjughated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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公开(公告)号：US10821171B2
公开(公告)日：2020-11-03
申请号：US16242799
申请日：2019-01-08
Applicant: Pfizer Inc.
Inventor： Ye Che , Philip Ralph Dormitzer , Alexey Vyacheslavovich Gribenko , Luke David Handke , Avvari Krishna Prasad , Xiayang Qiu , Mark Edward Ruppen , Xi Song , Kena Anne Swanson , Srinivas Kodali , Xin Xu , KariAnn Sweeney Efferen , Ping Cai , Kristin Rachael Tompkins , Lorna del Pilar Nunez
IPC: A61K39/155 , C07K14/135 , A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
Abstract: The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.
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公开(公告)号：US10745438B2
公开(公告)日：2020-08-18
申请号：US16505757
申请日：2019-07-09
Applicant: Pfizer Inc.
Inventor： Mingming Han , Rajesh Kumar Kainthan , Jin-Hwan Kim , Avvari Krishna Prasad
IPC: C07K1/107 , C07K14/34 , C07K14/22 , C07K14/315 , A61K39/095 , A61K39/09 , A61K47/64 , C07H3/06 , A61K39/00
Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US20190070283A1
公开(公告)日：2019-03-07
申请号：US16166708
申请日：2018-10-22
Applicant: Pfizer Inc.
Inventor： Mingming Han , Avvari Krishna Prasad , David Cooper , Wendy Jo Watson
IPC: A61K39/09 , A61K39/39 , A61K39/385 , A61K39/00
Abstract: The invention relates to isolated Streptococcus pneumoniae serotype 15B capsular polysaccharide and processes for their preparation. The invention also relates to immunogenic conjugates comprising Streptococcus pneumoniae serotype 15B capsular polysaccharide covalently linked to a carrier protein, processes for their preparation and immunogenic compositions comprising them.
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