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公开(公告)号：US20240122865A1
公开(公告)日：2024-04-18
申请号：US18275634
申请日：2022-02-15
Applicant: Pfizer Inc.
Inventor： Justin Leigh Bellenger , Ye Che , Miguel Angel Garcia , Lei Hu , Mark Carl Noe , Shuai Shi
CPC classification number: A61K9/5123 , A61K9/4858 , A61K39/12
Abstract: The present disclosure provides methods of protecting ribonucleic acid (RNA) from degradation under certain conditions by contacting the RNA with an amino acid. The present disclosure also provides compositions comprising such amino acid(s) and RNA.
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公开(公告)号：US20220000999A1
公开(公告)日：2022-01-06
申请号：US17474561
申请日：2021-09-14
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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3.发明公开公开(公告)号：US20240189410A1
公开(公告)日：2024-06-13
申请号：US18535116
申请日：2023-12-11
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Marina A. Gonzalez-Garis , Lei Hu , Isis Kanevsky , Paul Arthur Liberator , Justin Keith Moran , Lynn Marie Phelan , Michael William Pride , Shuai Shi , Naveen Surendran
CPC classification number: A61K39/08 , A61K39/39 , A61P31/04 , A61K2039/55561
Abstract: The present invention relates to immunogenic compositions that comprise a Clostridioides difficile toxoid A and/or a C. difficile toxoid B, and an adjuvant, and methods of use thereof. The present invention further relate to a methods for eliciting an enhanced immune response in a human against a C. difficile infection. The methods include administering to the human an effective dose of an immunogenic composition, which includes a C. difficile toxoid and an adjuvant, wherein the composition is administered two times.
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公开(公告)号：US20200368340A1
公开(公告)日：2020-11-26
申请号：US16984499
申请日：2020-08-04
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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Patent Agency Ranking
公开(公告)号：US10751402B2
公开(公告)日：2020-08-25
申请号：US15800373
申请日：2017-11-01
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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公开(公告)号：US20180125958A1
公开(公告)日：2018-05-10
申请号：US15800373
申请日：2017-11-01
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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公开(公告)号：US20240299523A1
公开(公告)日：2024-09-12
申请号：US18660419
申请日：2024-05-10
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
CPC classification number: A61K39/092 , A61K39/39 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B Streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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公开(公告)号：US12016913B2
公开(公告)日：2024-06-25
申请号：US17474561
申请日：2021-09-14
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
CPC classification number: A61K39/092 , A61K39/39 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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公开(公告)号：US11147865B2
公开(公告)日：2021-10-19
申请号：US16984499
申请日：2020-08-04
Applicant: Pfizer Inc.
Inventor： Annaliesa Sybil Anderson , Leena Shriram Bagle , Amardeep Singh Bhupender Bhalla , Miguel Angel Garcia , Lei Hu , Lakshmi Khandke , Avvari Krishna Prasad , Cindy Xudong Yang
Abstract: The invention relates to immunogenic compositions comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B Streptococcus (GBS), conjugated to a carrier protein, and optionally including an aluminum-based adjuvant. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.
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