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    IMMUNOGENIC GLYCOPROTEIN CONJUGATES
    16.
    发明公开
    IMMUNOGENIC GLYCOPROTEIN CONJUGATES 审中-公开

    公开(公告)号：US20240033367A1

    公开(公告)日：2024-02-01

    申请号：US18330144

    申请日：2023-06-06

    Applicant: Pfizer Inc.

    Inventor： Jianxin Gu ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad ,  Yu-Ying Yang

    IPC: A61K47/64 ,  A61K39/09

    CPC classification number: A61K47/6415 ,  A61K39/092 ,  A61K47/646 ,  A61K2039/6037

    Abstract: The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing ((2-oxoethyl)thio)). In an aspect the invention provides oxo-eT linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ((2-oxoethyl)thio) spacer having the formula (I):






    wherein:
    A is a group (C═X)m wherein X is S or O and m is 0 or 1;
    B is a bond, O, or CH2; and when m is 0, B can also be (C═O);
    R is a C2-C16 alkylene, C2-C16 heteroakylene, NH—C(═O)—C2-C16 alkylene, or NH—C(═O)—C2-C16 heteroakylene, wherein said alkylene and heteroalkylene are optionally substituted by 1, 2 or 3 groups independently selected from COOR′ where R′ is selected from H, methyl, ethyl or propyl.




    The invention further relates to immunogenic compositions comprising such glycoconjugates, and to methods for the preparation and use of such glycoconjugates and immunogenic compositions.

    Immunogenic glycoprotein conjugates
    17.
    发明授权
    Immunogenic glycoprotein conjugates 有权

    公开(公告)号：US11707529B2

    公开(公告)日：2023-07-25

    申请号：US16852697

    申请日：2020-04-20

    Applicant: Pfizer Inc.

    Inventor： Jianxin Gu ,  Rajesh Kumar Kainthan ,  Jin-Hwan Kim ,  Avvari Krishna Prasad ,  Yu-Ying Yang

    IPC: C07K1/107 ,  A61K47/64 ,  A61K39/09 ,  A61K39/00

    CPC classification number: A61K47/6415 ,  A61K39/092 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/627 ,  C07K1/1077

    Abstract: The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing ((2-oxoethyl)thio)). In an aspect the invention provides oxo-eT linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ((2-oxoethyl)thio) spacer having the formula (I):




    wherein:
    A is a group (C═X)m wherein X is S or O and m is 0 or 1;
    B is a bond, O, or CH2; and when m is 0, B can also be (C═O);
    R is a C2-C16 alkylene, C2-C16 heteroakylene, NH—C(═O)—C2-C16 alkylene, or NH—C(═O)—C2-C16 heteroakylene, wherein said alkylene and heteroalkylene are optionally substituted by 1, 2 or 3 groups independently selected from COOR′ where R′ is selected from H, methyl, ethyl or propyl.


    The invention further relates to immunogenic compositions comprising such glycoconjugates, and to methods for the preparation and use of such glycoconjugates and immunogenic compositions.

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