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11.发明申请公开(公告)号：US20190150401A1
公开(公告)日：2019-05-23
申请号：US16268857
申请日：2019-02-06
Applicant: Pfizer Inc.
Inventor： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC: A01K5/01 , B65D77/20 , B65D25/04 , B65D1/34 , A01K7/00 , B65D25/18 , A23K20/00 , A23K50/48 , B65D1/36
CPC classification number: A01K5/0121 , A01K7/00 , A23K20/00 , A23K50/48 , B65D1/34 , B65D1/36 , B65D25/04 , B65D25/18 , B65D77/2024 , B65D85/70 , B65D2577/205 , C07D401/14 , C07D471/04
Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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12.发明授权公开(公告)号：US10227346B2
公开(公告)日：2019-03-12
申请号：US15889296
申请日：2018-02-06
Applicant: Pfizer Inc.
Inventor： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC: A61K31/437 , A61K31/4353 , C07D471/04 , C07D401/14
Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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公开(公告)号：US20180002330A1
公开(公告)日：2018-01-04
申请号：US15546887
申请日：2016-01-29
Applicant: Pfizer Inc.
Inventor： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand J. Unwalla
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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公开(公告)号：US20170233371A1
公开(公告)日：2017-08-17
申请号：US15497862
申请日：2017-04-26
Applicant: Pfizer Inc.
Inventor： Mark Edward Schnute , Gõran Mattias Wennerstål , James Robert Blinn , Neelu Kaila , James Richard Kiefer, Jr. , Scot Richard Mente , Ravi G. Kurumbail , Marvin Jay Meyers , Atli Thorarensen , Li Xing , Christoph Wolfgang Zapf , Edouard Zamaratski , Andrew Christopher Flick , Peter Jones
IPC: C07D401/14 , C07D413/14 , C07D405/14 , C07D413/04 , C07D471/04 , C07D487/04 , C07D403/04 , C07D401/04 , C07D417/14
CPC classification number: C07D401/14 , A61K31/454 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5355 , C07D401/04 , C07D403/04 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/406 , A61K2300/00
Abstract: The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.
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公开(公告)号：US09518052B2
公开(公告)日：2016-12-13
申请号：US14710631
申请日：2015-05-13
Applicant: Pfizer Inc.
Inventor： Jotham Wadsworth Coe , Christoph Martin Dehnhardt , Peter Jones , Yogesh Anil Sabnis , Joseph Walter Strohbach , Florian Michel Wakenhut , Gavin Alistair Whitlock
IPC: C07D471/04 , C07D487/04
CPC classification number: A61K31/519 , A61K31/437 , A61K31/4725 , C07D471/04 , C07D487/04
Abstract: A compound having the structure: or a pharmaceutically acceptable salt or solvate thereof, wherein A and A′ are C or N, where C may be substituted by halo or C1-C6 alkyl; R and R0 are selected from the group consisting of H, C1-C6 alkyl, —(CH2)n—W, etc., where W is 5- or 6-membered heteroaryl or heterocyclic containing N, S and/or O atoms, —NR″SO2—R′, etc., where R′ and R″ are C1-C6 alkyl, etc.; wherein each alkyl, etc., may be substituted; or, R and R0 and the N atom to which they are bonded together to form a monocyclic or bicyclic heterocyclic ring, etc.; R1 is H, halo or cyano; R2 and R2′ are H, C1-C6 alkyl, etc.; X is a bond, etc.; R3 is H, C1-C4 alkyl, etc.; Y is a bond, —(CH2)m—, etc. The invention also relates to compositions and uses in the treatment of various diseases.
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Patent Agency Ranking
公开(公告)号：US20160046597A1
公开(公告)日：2016-02-18
申请号：US14448220
申请日：2014-07-31
Applicant: PFIZER INC.
Inventor： Mark Edward Schnute , Göran Mattias Wennerstål , James Robert Blinn , Neelu Kaila , James Richard Kiefer, JR. , Scot Richard Mente , Ravi G. Kurumbail , Marvin Jay Meyers , Atli Thorarensen , Li Xing , Christoph Wolfgang Zapf , Edouard Zamaratski , Andrew Christopher Flick , Peter Jones
IPC: C07D401/04 , C07D413/14 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D401/14 , C07D405/14
CPC classification number: C07D401/14 , A61K31/454 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5355 , C07D401/04 , C07D403/04 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/406 , A61K2300/00
Abstract: The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.
Abstract translation: 本发明提供化合物，药物组合物，抑制受试者的RORγ活性和/或减少IL-17的量的方法，以及使用这些化合物和药物组合物治疗各种医学病症的方法。
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公开(公告)号：US20210069219A1
公开(公告)日：2021-03-11
申请号：US17082102
申请日：2020-10-28
Applicant: Pfizer Inc.
Inventor： Joseph Walter Strohbach , Tsutomu Akama , David Clive Blakemore , Robert Toms Jacobs , Peter Jones , David Christopher Limburg , Martins Sunday Oderinde , Matthew Alexander Perry , Jacob John Plattner , Rubben Federico Torella , Yasheen Zhou , Thean Yeow Yeoh
IPC: A61K31/69 , A61K31/519 , C07F5/02
Abstract: The present invention relates to boron containing compounds of Formula (I) X—Y—Z Formula (I) that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.
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公开(公告)号：US20200039960A1
公开(公告)日：2020-02-06
申请号：US16656702
申请日：2019-10-18
Applicant: Pfizer Inc.
Inventor： Mark Edward Schnute , Göran Mattias Wennerstål , James Robert Blinn , Neelu Kaila , James Richard Kiefer, Jr. , Scot Richard Mente , Ravi G. Kurumbail , Marvin Jay Meyers , Atli Thorarensen , Li Xing , Christoph Wolfgang Zapf , Edouard Zamaratski , Andrew Christopher Flick , Peter Jones
IPC: C07D401/14 , C07D413/14 , A61K31/454 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5355 , C07D407/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D401/04 , C07D403/04 , C07D405/14
Abstract: The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.
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公开(公告)号：US20190270778A1
公开(公告)日：2019-09-05
申请号：US16319985
申请日：2017-07-17
Applicant: Pfizer Inc.
Inventor： Ye Che , Yiqing Feng , Matthew Merrill Hayward , David Hepworth , Peter Jones , Kaila Neelu , Nikolaos Papaioannou
Abstract: The invention relates to cyclic peptide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to cyclic peptide C5a receptor antagonists of formula (Ia) or formula (Ib), or pharmaceutically acceptable salts thereof, wherein R1a, R1b, R2, R3 and R4 areas defined in the description. C5a receptor antagonists are potentially useful in the treatment of a wide range of 1 disorders, including inflammatory disorders and immune disorders.
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公开(公告)号：US10385036B2
公开(公告)日：2019-08-20
申请号：US15547228
申请日：2016-01-29
Applicant: Pfizer Inc.
Inventor： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand J. Unwalla
IPC: C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrrolopyridines, pharmaceutical compositions thereof methods of modulating RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such indoles and pharmaceutical compositions thereof.
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