公开(公告)号：US10966980B2

公开(公告)日：2021-04-06

申请号：US14822265

申请日：2015-08-10

Applicant: Pfizer Inc.

Inventor： Michael L. Vazquez ,  Neelu Kaila ,  Jamison B. Tuttle ,  Patrick Robert Verhoest ,  Matthew R. Reese ,  Karen J. Coffman ,  Tarek Samad ,  James M. Duerr ,  Simone Sciabola ,  Mihir D. Parikh

IPC: C07D487/04 ,  C07D519/00 ,  C07D491/052 ,  C07D498/08 ,  C07D491/044 ,  A61K45/06 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5386

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing them, and therapeutic uses thereof.

公开(公告)号：US20190144429A1

公开(公告)日：2019-05-16

申请号：US16261689

申请日：2019-01-30

Applicant: Pfizer Inc.

Inventor： Mark Edward Schnute ,  Gõran Mattias Wennerstål ,  James Robert Blinn ,  Neelu Kaila ,  James Richard Kiefer, JR. ,  Scot Richard Mente ,  Ravi G. Kurumbail ,  Marvin Jay Meyers ,  Atli Thorarensen ,  Li Xing ,  Christoph Wolfgang Zapf ,  Edouard Zamaratski ,  Andrew Christopher Flick ,  Peter Jones

IPC: C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D403/04 ,  C07D487/04 ,  C07D471/04 ,  C07D417/14 ,  C07D413/04 ,  C07D407/14 ,  C07D401/04 ,  A61K31/5355 ,  A61K31/519 ,  A61K31/506 ,  A61K31/497 ,  A61K31/454

Abstract: The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.

公开(公告)号：US09545405B2

公开(公告)日：2017-01-17

申请号：US14691606

申请日：2015-04-21

Applicant: Pfizer Inc.

Inventor： Matthew Frank Brown ,  Ashley Edward Fenwick ,  Mark Edward Flanagan ,  Andrea Gonzales ,  Timothy Allan Johnson ,  Neelu Kaila ,  Mark J. Mitton-Fry ,  Joseph Walter Strohbach ,  Ruth E. TenBrink ,  John David Trzupek ,  Rayomand Jal Unwalla ,  Michael L. Vazquez ,  Mihir D. Parikh

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  C07D487/04 ,  C07D519/00 ,  A61K31/5386 ,  C07D207/18

CPC classification number: A61K31/519 ,  A61K31/5386 ,  C07D207/18 ,  C07D487/04 ,  C07D519/00

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

公开(公告)号：US20150246048A1

公开(公告)日：2015-09-03

申请号：US14715046

申请日：2015-05-18

Applicant: Pfizer Inc.

Inventor： Matthew Frank Brown ,  Ashley Edward Fenwick ,  Mark Edward Flanagan ,  Andrea Gonzales ,  Timothy Allan Johnson ,  Neelu Kaila ,  Mark J. Mitton-Fry ,  Joseph Walter Strohbach ,  Ruth E. TenBrink ,  John David Trzupek ,  Rayomand Jal Unwalla ,  Michael L. Vazquez ,  Mihir D. Parikh

IPC: A61K31/519 ,  A61K31/5386

CPC classification number: A61K31/519 ,  A61K31/5386 ,  C07D207/18 ,  C07D487/04 ,  C07D519/00

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract translation: 本文描述的是吡咯并[2,3-d]嘧啶衍生物，它们用作Janus Kinase（JAK）抑制剂，以及含有它们的药物组合物。

公开(公告)号：US20180273504A1

公开(公告)日：2018-09-27

申请号：US15547228

申请日：2016-01-29

Applicant: Pfizer Inc.

Inventor： Mark Edward Schnute ,  Andrew Christopher Flick ,  Peter Jones ,  Neelu Kaila ,  Scot Richard Mente ,  John David Trzupek ,  Michael L. Vazquez ,  Goran Mattias Wennerstal ,  Li Xing ,  Edouard Zamaratski ,  Liying Zhang ,  Rayomand J. Unwalla

IPC: C07D401/04 ,  A61P29/00 ,  A61P37/06 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/04 ,  A61P29/00 ,  A61P37/06 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrro-lopyridines, pharmaceutical compositions thereof methods of modulating RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such indoles and pharmaceutical compositions thereof.

公开(公告)号：US09035074B2

公开(公告)日：2015-05-19

申请号：US14183946

申请日：2014-02-19

Applicant: Pfizer Inc.

Inventor： Matthew Frank Brown ,  Ashley Edward Fenwick ,  Mark Edward Flanagan ,  Andrea Gonzales ,  Timothy Allan Johnson ,  Neelu Kaila ,  Mark J. Mitton-Fry ,  Joseph Walter Strohbach ,  Ruth E. TenBrink ,  John David Trzupek ,  Rayomand Jal Unwalla ,  Michael L. Vazquez ,  Mihir D. Parikh

IPC: C07D207/18 ,  C07D487/04 ,  C07D519/00

CPC classification number: A61K31/519 ,  A61K31/5386 ,  C07D207/18 ,  C07D487/04 ,  C07D519/00

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract translation: 本文描述的是吡咯并[2,3-d]嘧啶衍生物，它们用作Janus Kinase（JAK）抑制剂，以及含有它们的药物组合物。

公开(公告)号：US20190387710A1

公开(公告)日：2019-12-26

申请号：US16563022

申请日：2019-09-06

Applicant: Pfizer Inc.

Inventor： Mark Edward Schnute ,  Andrew Christopher Flick ,  Peter Jones ,  Neelu Kaila ,  Scot Richard Mente ,  John David Trzupek ,  Michael L. Vazquez ,  Goran Mattias Wennerstal ,  Li Xing ,  Edouard Zamaratski ,  Liying Zhang ,  Rayomand Jal Unwalla

IPC: A01K5/01 ,  B65D25/18 ,  B65D25/04 ,  B65D1/36 ,  B65D1/34 ,  A01K7/00 ,  B65D77/20 ,  A23K20/00 ,  A23K50/48 ,  C07D471/04 ,  C07D401/14

Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

公开(公告)号：US10336748B2

公开(公告)日：2019-07-02

申请号：US15546887

申请日：2016-01-29

Applicant: Pfizer Inc.

Inventor： Mark Edward Schnute ,  Andrew Christopher Flick ,  Peter Jones ,  Neelu Kaila ,  Scot Richard Mente ,  John David Trzupek ,  Michael L. Vazquez ,  Goran Mattias Wennerstal ,  Li Xing ,  Edouard Zamaratski ,  Liying Zhang ,  Rayomand J. Unwalla

IPC: C07D471/04

Abstract: The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

公开(公告)号：US20190150401A1

公开(公告)日：2019-05-23

申请号：US16268857

申请日：2019-02-06

Applicant: Pfizer Inc.

Inventor： Mark Edward Schnute ,  Andrew Christopher Flick ,  Peter Jones ,  Neelu Kaila ,  Scot Richard Mente ,  John David Trzupek ,  Michael L. Vazquez ,  Goran Mattias Wennerstal ,  Li Xing ,  Edouard Zamaratski ,  Liying Zhang ,  Rayomand Jal Unwalla

IPC: A01K5/01 ,  B65D77/20 ,  B65D25/04 ,  B65D1/34 ,  A01K7/00 ,  B65D25/18 ,  A23K20/00 ,  A23K50/48 ,  B65D1/36

CPC classification number: A01K5/0121 ,  A01K7/00 ,  A23K20/00 ,  A23K50/48 ,  B65D1/34 ,  B65D1/36 ,  B65D25/04 ,  B65D25/18 ,  B65D77/2024 ,  B65D85/70 ,  B65D2577/205 ,  C07D401/14 ,  C07D471/04

Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

公开(公告)号：US10227346B2

公开(公告)日：2019-03-12

申请号：US15889296

申请日：2018-02-06

Applicant: Pfizer Inc.

Inventor： Mark Edward Schnute ,  Andrew Christopher Flick ,  Peter Jones ,  Neelu Kaila ,  Scot Richard Mente ,  John David Trzupek ,  Michael L. Vazquez ,  Goran Mattias Wennerstal ,  Li Xing ,  Edouard Zamaratski ,  Liying Zhang ,  Rayomand Jal Unwalla

IPC: A61K31/437 ,  A61K31/4353 ,  C07D471/04 ,  C07D401/14

Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.