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公开(公告)号：US20180221467A1
公开(公告)日：2018-08-09
申请号：US15946664
申请日：2018-04-05
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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12.发明申请Immunogenic Compositions Comprising Conjugated Capsular Saccharide Antigens and Uses Thereof 有权包含共轭荚膜糖抗原的免疫原性组合物及其用途公开(公告)号：US20150202309A1
公开(公告)日：2015-07-23
申请号：US14597488
申请日：2015-01-15
Applicant: PFIZER INC.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
CPC classification number: A61K47/4833 , A61K39/092 , A61K47/646 , A61K2039/6037 , A61K2039/70 , Y02A50/466
Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.
Abstract translation: 本发明涉及包含结合性肺炎链球菌荚膜糖抗原（糖缀合物）的新的免疫原性组合物及其应用。 本发明的免疫原性组合物通常将包含至少一种来自PREVNAR，SYNFLORIX和/或PREVNAR 13中没有发现的肺炎链球菌血清型的糖缀合物。 本发明还涉及使用所述新型免疫原性组合物对人受试者，特别是婴儿和老年人免疫肺炎球菌感染。
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公开(公告)号：US20230355735A1
公开(公告)日：2023-11-09
申请号：US18338961
申请日：2023-06-21
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06
CPC classification number: A61K39/095 , A61K47/646 , A61K47/64 , A61K39/092 , A61K45/06 , A61K47/6415 , A61K2039/6068
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US11110160B2
公开(公告)日：2021-09-07
申请号：US16774309
申请日：2020-01-28
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K39/095 , A61K47/64 , A61K39/09 , A61K45/06 , A61K39/00
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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Patent Agency Ranking
15.发明申请公开(公告)号：US20210196810A1
公开(公告)日：2021-07-01
申请号：US17194224
申请日：2021-03-06
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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16.发明申请公开(公告)号：US20200306357A1
公开(公告)日：2020-10-01
申请号：US16899738
申请日：2020-06-12
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
Abstract: The present invention relates to new immunogenic compositions comprising conjughated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.
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公开(公告)号：US09950054B2
公开(公告)日：2018-04-24
申请号：US15347034
申请日：2016-11-09
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , Avvari Krishna Prasad , Yu-ying Yang
IPC: A61K45/06 , A61K39/095 , A61K39/09 , A61K47/48 , A61K39/00
CPC classification number: A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
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公开(公告)号：US09517274B2
公开(公告)日：2016-12-13
申请号：US14420822
申请日：2013-08-12
Applicant: PFIZER INC.
Inventor： Jianxin Gu , Jin-hwan Kim , A. Krishna Prasad , Yu-ying Yang
CPC classification number: A61K39/095 , A61K39/092 , A61K45/06 , A61K47/64 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/627
Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
Abstract translation: 本发明提供了包含通过（2 - （（2-氧代乙基）硫基）乙基）氨基甲酸酯（eTEC）间隔物共价结合载体蛋白质的糖的eTEC连接的糖缀合物，包含这种糖缀合物的免疫原性组合物，以及制备和使用 这样的糖缀合物和免疫原性组合物。
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19.发明授权Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof 有权包含共轭荚膜糖抗原的免疫原性组合及其用途公开(公告)号：US09492559B2
公开(公告)日：2016-11-15
申请号：US14597488
申请日：2015-01-15
Applicant: Pfizer Inc.
Inventor： Emilio Anthony Emini , Wendy Jo Watson , Avvari Krishna Prasad , Mingming Han , Jin-Hwan Kim , Jianxin Gu , Yu-ying Yang , Rajesh Kumar Kainthan , David Cooper , Michael William Pride , Kathrin Ute Jansen
IPC: A61K39/00 , A61K39/02 , A61K39/09 , A61K39/385 , A61K47/48
CPC classification number: A61K47/4833 , A61K39/092 , A61K47/646 , A61K2039/6037 , A61K2039/70 , Y02A50/466
Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.
Abstract translation: 本发明涉及包含结合性肺炎链球菌荚膜糖抗原（糖缀合物）的新的免疫原性组合物及其应用。 本发明的免疫原性组合物通常将包含至少一种来自PREVNAR，SYNFLORIX和/或PREVNAR 13中没有发现的肺炎链球菌血清型的糖缀合物。 本发明还涉及使用所述新型免疫原性组合物对人受试者，特别是婴儿和老年人免疫肺炎球菌感染。
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