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公开(公告)号：US20180044399A1
公开(公告)日：2018-02-15
申请号：US15525906
申请日：2015-11-09
Applicant: RINAT NEUROSCIENCE CORP. , CELLECTIS
Inventor： Arvind RAJPAL , Shobha Chowdary POTLURI , Laurent POIROT , Alexandre JUILLERAT , Thomas Charles PERTEL , Donna Marie STONE , Barbra Johnson SASU
IPC: C07K14/705 , C07K14/725 , A61K35/17 , C07K16/28 , C12N5/0783
CPC classification number: C07K14/70503 , A61K35/17 , A61K2039/5156 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/2803 , C07K16/3069 , C07K2317/622 , C07K2317/76 , C07K2319/03 , C07K2319/70 , C07K2319/74 , C12N5/0636 , C12N2510/00
Abstract: The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and, an intracellular domain wherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein said ITSM is a sequence of amino acid TX1YX2X3X4, wherein X1 is an amino acid X2 is an amino acid X3 is an amino acid and X4 is V or
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公开(公告)号：US20160257746A1
公开(公告)日：2016-09-08
申请号：US15160742
申请日：2016-05-20
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui LIU , Wei-Hsien HO , Pavel STROP , Magdalena Grazyna DORYWALSKA , Arvind RAJPAL , David Louis SHELTON , Thomas-Toan TRAN
CPC classification number: C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
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公开(公告)号：US20140357844A1
公开(公告)日：2014-12-04
申请号：US14460871
申请日：2014-08-15
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Shu-Hui LIU , Wei-Hsien HO , Pavel STROP , Magdalena Grazyna DORYWALSKA , Arvind RAJPAL , David Louis SHELTON , Thomas-Toan TRAN
CPC classification number: C07K16/28 , A61K38/08 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K16/3076 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
Abstract translation: 本发明提供特异性结合滋养层细胞表面抗原-2（Trop-2）的抗体。 本发明进一步提供了包含此类抗体的抗体缀合物，编码抗体的核酸，以及获得此类抗体的方法。 本发明还涉及这些抗体和Trop-2抗体缀合物用于治疗与Trop-2表达（例如癌症）如结肠，食管，胃，头颈部，肺， 卵巢癌或胰腺癌。
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公开(公告)号：US20220002428A1
公开(公告)日：2022-01-06
申请号：US17373965
申请日：2021-07-13
Applicant: Pfizer Inc. , Bristol-Myers Squibb Company
Inventor： Jing MIN , Yanli WU , Rory F. FINN , Barrett R. THIELE , Wei LIAO , Ronald P. GLADUE , Arvind RAJPAL , Timothy J. PARADIS , Peter BRAMS , Brigitte DEVAUX , Yi WU , Kristopher TOY , Heidi N. LEBLANC , Haichun HUANG
IPC: C07K16/28
Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
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公开(公告)号：US20180171018A1
公开(公告)日：2018-06-21
申请号：US15878344
申请日：2018-01-23
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K39/395 , A61K47/68 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/00
CPC classification number: C07K16/2878 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/6801 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , A61K2300/00
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
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Patent Agency Ranking
公开(公告)号：US20210188991A1
公开(公告)日：2021-06-24
申请号：US17129833
申请日：2020-12-21
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K39/395 , A61K31/454 , A61K31/704 , A61K31/69 , A61K47/68
Abstract: The present invention relates bispecific antibodies that specific binds to BCMA (B-Cell Maturation Antigen) and CD3 (Cluster of Differentiation 3). Method of making the bispecific antibodies and method of using the bispecific antibodies for the treatment of multiple myeloma are also provided.
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公开(公告)号：US20190241669A1
公开(公告)日：2019-08-08
申请号：US16384719
申请日：2019-04-15
Applicant: Pfizer Inc.
Inventor： Tracy Chia-Chien KUO , Bijan Andre BOLDAJIPOUR , Javier Fernando CHAPARRO RIGGERS , Philippe DUCHATEAU , Roman Ariel GALETTO , Alexandre JUILLERAT , Thomas Charles PERTEL , Arvind RAJPAL , Barbra Johnson SASU , Cesar Adolfo SOMMER , Julien VALTON , Thomas John VAN BLARCOM
IPC: C07K16/28 , C07K14/705 , A61K31/7076 , A61K35/17 , C12N15/63 , C07K14/725 , A61K39/00
CPC classification number: C07K16/2878 , A61K31/7076 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/505 , A61K2039/5156 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/2863 , C07K16/2896 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C07K2319/33 , C12N15/63
Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).
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公开(公告)号：US20240018252A1
公开(公告)日：2024-01-18
申请号：US18456399
申请日：2023-08-25
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K31/454 , A61K39/395 , A61K38/07 , A61P35/00 , A61K31/704
CPC classification number: C07K16/2878 , C07K16/2809 , A61K31/454 , A61K39/3955 , A61K38/07 , A61P35/00 , A61K31/704 , C07K2317/31 , A61K39/00
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
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公开(公告)号：US20190135932A1
公开(公告)日：2019-05-09
申请号：US16245816
申请日：2019-01-11
Applicant: Pfizer Inc. , Bristol-Myers Squibb Company
Inventor： Jing MIN , Yanli WU , Rory F. FINN , Barrett R. THIELE , Wei LIAO , Ronald P. GLADUE , Arvind RAJPAL , Timothy J. PARADIS , Peter BRAMS , Brigitte DEVAUX , Yi WU , Kristopher TOY , Heidi N. LEBLANC , Haichun HUANG
IPC: C07K16/28
Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
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公开(公告)号：US20180298108A1
公开(公告)日：2018-10-18
申请号：US16017974
申请日：2018-06-25
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K39/395 , A61K31/704 , A61K31/454 , A61K47/68
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
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