公开(公告)号：US07641905B2

公开(公告)日：2010-01-05

申请号：US11154298

申请日：2005-06-15

申请人： Aya Jakobovits ,  Pia M. Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene S. Hubert ,  Karen Jane Meyrick Morrison ,  Robert Kendall Morrison ,  Arthur B. Raitano ,  Daniel E. H. Afar

发明人： Aya Jakobovits ,  Pia M. Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene S. Hubert ,  Karen Jane Meyrick Morrison ,  Robert Kendall Morrison ,  Arthur B. Raitano ,  Daniel E. H. Afar

IPC分类号： A61K39/00

CPC分类号： C07K14/47 ,  A61K47/646 ,  A61K47/6851 ,  A61K47/6901 ,  A61K51/1045

摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.

摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。

公开(公告)号：US07488479B2

公开(公告)日：2009-02-10

申请号：US10099460

申请日：2002-03-13

申请人： Mary Faris ,  Pia M. Challita-Eid ,  Rene S. Hubert ,  Daniel E. H. Afar ,  Arthur B. Raitano ,  Wangmao Ge ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Aya Jakobovits

发明人： Mary Faris ,  Pia M. Challita-Eid ,  Rene S. Hubert ,  Daniel E. H. Afar ,  Arthur B. Raitano ,  Wangmao Ge ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Aya Jakobovits

IPC分类号： A61K39/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  Y02A50/466

摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后， 癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US08647826B2

公开(公告)日：2014-02-11

申请号：US13052002

申请日：2011-03-18

申请人： Mary Faris ,  Pia M. Challita-Eid ,  Rene S. Hubert ,  Daniel E. H. Afar ,  Arthur B. Raitano ,  Wangmao Ge ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Aya Jakobovits

发明人： Mary Faris ,  Pia M. Challita-Eid ,  Rene S. Hubert ,  Daniel E. H. Afar ,  Arthur B. Raitano ,  Wangmao Ge ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Aya Jakobovits

IPC分类号： G01N33/53

CPC分类号： C07K14/4748 ,  A61K31/7088 ,  A61K38/1764 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57434

摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后， 癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US20100266498A1

公开(公告)日：2010-10-21

申请号：US12820083

申请日：2010-06-21

申请人： Mary FARIS ,  Pia M. Challita-Eid ,  Rene S. Hubert ,  Daniel E. H. Afar ,  Arthur B. Raitano ,  Wangmao Ge ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Aya Jakobovits

发明人： Mary FARIS ,  Pia M. Challita-Eid ,  Rene S. Hubert ,  Daniel E. H. Afar ,  Arthur B. Raitano ,  Wangmao Ge ,  Robert Kendall Morrison ,  Karen Jane Meyrick Morrison ,  Aya Jakobovits

IPC分类号： A61K51/10 ,  C07K14/435 ,  A61K39/395 ,  A61P35/00 ,  G01N33/53 ,  C12Q1/68 ,  C12N5/09

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  Y02A50/466

摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.

摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后， 癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。

公开(公告)号：US07736654B2

公开(公告)日：2010-06-15

申请号：US10121024

申请日：2002-04-10

申请人： Aya Jakobovits ,  Pia M. Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene S. Hubert ,  Karen Jane Meyrick Morrison ,  Robert Kendall Morrison ,  Arthur B. Raitano ,  Daniel E. H. Afar

发明人： Aya Jakobovits ,  Pia M. Challita-Eid ,  Mary Faris ,  Wangmao Ge ,  Rene S. Hubert ,  Karen Jane Meyrick Morrison ,  Robert Kendall Morrison ,  Arthur B. Raitano ,  Daniel E. H. Afar

IPC分类号： A61K39/00

CPC分类号： C07K14/47 ,  A61K47/646 ,  A61K47/6851 ,  A61K47/6901 ,  A61K51/1045

摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.

摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。

公开(公告)号：US07199220B2

公开(公告)日：2007-04-03

申请号：US10283903

申请日：2002-10-29

申请人： Arthur B. Raitano ,  Daniel E. H. Afar ,  Gazelle S. Rastegar ,  Steve Chappell Mitchell ,  Rene S. Hubert ,  Pia M. Challita-Eid ,  Mary Faris ,  Aya Jakobovits

发明人： Arthur B. Raitano ,  Daniel E. H. Afar ,  Gazelle S. Rastegar ,  Steve Chappell Mitchell ,  Rene S. Hubert ,  Pia M. Challita-Eid ,  Mary Faris ,  Aya Jakobovits

IPC分类号： C07K14/47 ,  C07K14/705

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/622 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.

公开(公告)号：US07534417B2

公开(公告)日：2009-05-19

申请号：US09793451

申请日：2001-02-26

申请人： Arthur B. Raitano ,  Daniel E. H. Afar ,  Gazelle S. Rastegar ,  Steve Chappell Mitchell ,  Rene S. Hubert ,  Pia M. Challita-Eid ,  Mary Faris ,  Aya Jakobovits

发明人： Arthur B. Raitano ,  Daniel E. H. Afar ,  Gazelle S. Rastegar ,  Steve Chappell Mitchell ,  Rene S. Hubert ,  Pia M. Challita-Eid ,  Mary Faris ,  Aya Jakobovits

IPC分类号： A61K51/10 ,  A61K39/395 ,  C07H21/04 ,  C07K14/00

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/622 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.

摘要翻译： 描述了一种新型基因（称为103P2D6）及其编码的蛋白质。 103P2D6在正常成人组织中不表达，但在前列腺组织异种移植物中高度表达，提供了在前列腺癌中开启的证据。 103P2D6也在一些胎儿组织，乳腺，膀胱，肺，骨，结肠，胰腺，睾丸，宫颈和卵巢癌中表达。 因此，103P2D6为癌症提供诊断和/或治疗靶标，103P2D6基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。

公开(公告)号：US07172898B2

公开(公告)日：2007-02-06

申请号：US10283722

申请日：2002-10-29

申请人： Arthur B. Raitano ,  Daniel E. H. Afar ,  Gazelle S. Rastegar ,  Steve Chappell Mitchell ,  Rene S. Hubert ,  Pia M. Challita-Eid ,  Mary Faris ,  Aya Jakobovits

发明人： Arthur B. Raitano ,  Daniel E. H. Afar ,  Gazelle S. Rastegar ,  Steve Chappell Mitchell ,  Rene S. Hubert ,  Pia M. Challita-Eid ,  Mary Faris ,  Aya Jakobovits

IPC分类号： C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12N1/15 ,  C12N1/21

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/622 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.

摘要翻译： 描述了一种新型基因（称为103P2D6）及其编码的蛋白质。 103P2D6在正常成人组织中不表达，但在前列腺组织异种移植物中高度表达，提供了在前列腺癌中开启的证据。 103P2D6也在一些胎儿组织，乳腺，膀胱，肺，骨，结肠，胰腺，睾丸，宫颈和卵巢癌中表达。 因此，103P2D6为癌症提供诊断和/或治疗靶标，103P2D6基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。

公开(公告)号：US06924358B2

公开(公告)日：2005-08-02

申请号：US09799250

申请日：2001-03-05

申请人： Pia M. Challita-Eid ,  Rene S. Hubert ,  Steve Chappell Mitchell ,  Arthur B. Raitano ,  Mary Faris ,  Daniel E. H. Afar ,  Aya Jakobovits

发明人： Pia M. Challita-Eid ,  Rene S. Hubert ,  Steve Chappell Mitchell ,  Arthur B. Raitano ,  Mary Faris ,  Daniel E. H. Afar ,  Aya Jakobovits

IPC分类号： A61K38/00 ,  C07K14/47 ,  G01N33/574 ,  A61K33/00 ,  C07K1/00 ,  C07H21/04

CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K14/47 ,  Y02A50/465 ,  Y02A50/473

摘要： A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ovarian, breast, pancreatic, stomach, colon, rectal, leukocytic, liver and lung cancers. Consequently, 121P1F1 provides a diagnostic and/or therapeutic target for cancers, and the 121P1F1 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.

摘要翻译： 描述了一种新型基因（称为121P1F1）及其编码的蛋白质。 121P1F1在正常成人组织中表现出组织特异性表达，但其在前列腺，膀胱，肾，脑，骨，子宫颈，子宫，卵巢，乳腺，胰腺，胃，结肠，直肠，白细胞，肝，肺等多种癌症中异常表达 癌症 因此，121P1F1提供癌症的诊断和/或治疗靶标，以及用于引发免疫应答的121P1F1基因或其片段，或其编码的蛋白质或其片段。

公开(公告)号：US08013126B2

公开(公告)日：2011-09-06

申请号：US12324707

申请日：2008-11-26

申请人： Aya Jakobovits ,  Daniel E. H. Afar ,  Pia M. Challita-Eid ,  Elana Levin ,  Steve Chappell Mitchell ,  Rene S. Hubert

发明人： Aya Jakobovits ,  Daniel E. H. Afar ,  Pia M. Challita-Eid ,  Elana Levin ,  Steve Chappell Mitchell ,  Rene S. Hubert

IPC分类号： C12P21/08 ,  C07K16/00 ,  C07K17/00 ,  C07K17/14 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  Y02A50/466

摘要： A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphocytic and lung cancers. Consequently, 84P2A9 provides a diagnostic and/or therapeutic target for cancers, and the 84P2A9 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.

摘要翻译： 描述了一种新型基因（称为84P2A9）及其编码的蛋白质。 虽然84P2A9在正常成人组织中表现出前列腺和睾丸特异性表达，但是异常表达多种癌症，包括前列腺，睾丸，肾，脑，骨，皮肤，卵巢，乳腺，胰腺，结肠，淋巴细胞和肺癌。 因此，84P2A9提供了用于癌症的诊断和/或治疗靶标，以及用于引发免疫应答的84P2A9基因或其片段或其编码的蛋白质或其片段。