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公开(公告)号：US20120288896A1
公开(公告)日：2012-11-15
申请号：US13558256
申请日：2012-07-25
申请人： Ruth Greferath , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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12.发明申请METHODS OF TREATING AMYLOIDOSIS COMPRISING THE USE OF ANTI-AMYLOID BETA ANTIBODIES 审中-公开治疗包含抗Aβ抗体的AMYLOIDOSIS的方法公开(公告)号：US20120244165A1
公开(公告)日：2012-09-27
申请号：US13461658
申请日：2012-05-01
申请人： Ruth Greferath , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
IPC分类号： A61K39/395 , A61P25/28
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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公开(公告)号：US20070135389A1
公开(公告)日：2007-06-14
申请号：US11497566
申请日：2006-08-01
申请人： Claude Nicolau , Jean-Marie Lehn
发明人： Claude Nicolau , Jean-Marie Lehn
CPC分类号： A61K31/6615 , A61K31/665 , C07F9/65746
摘要： The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
摘要翻译： 本发明涉及三水合磷酸肌醇的各种盐，包括三水合磷酸肌醇的钙，锂，铍，镁，钾，锶，钡，铷和铯盐，包含这些盐的组合物，制备各种盐的方法和使用方法 的上述盐。 使用方法包括在个体中施用有效量的上述盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症。
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14.发明申请Calcium salt of myo-inositol 1,6:2,3:4,5 tripyrophosphate as an allosteric effector of hemoglobin 审中-公开肌醇1,6：2,3：4,5三磷酸钙作为血红蛋白的变构效应物公开(公告)号：US20060241086A1
公开(公告)日：2006-10-26
申请号：US11384012
申请日：2006-03-17
CPC分类号： C07F9/65746 , A61K31/6615
摘要： The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
摘要翻译： 本发明涉及三水合磷酸肌醇的各种盐，包括三水合磷酸肌醇的钙，锂，铍，镁，钾，锶，钡，铷和铯盐，包含这些盐的组合物，制备各种盐的方法和使用方法 的上述盐。 使用方法包括在个体中施用有效量的上述盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症。
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15.发明授权Palmitoylated AB 1-15 in a liposome as a treatment for amyloid associated diseases 有权脂质体中的棕榈酰化AB 1-15作为淀粉样蛋白相关疾病的治疗公开(公告)号：US08603487B2
公开(公告)日：2013-12-10
申请号：US12386140
申请日：2009-04-14
申请人： Andrea Pfeifer , Claude Nicolau
发明人： Andrea Pfeifer , Claude Nicolau
IPC分类号： A61K39/385 , A61K38/10 , A61K39/00
CPC分类号： A61K39/0008 , C07K16/18 , Y10S424/812
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis.In particular, the present invention provides novel methods and compositions for eliciting a highly specific and highly effective immune response in an organism, but particularly within an animal, particularly a mammal or a human, which is capable of preventing or alleviating amyloidosis, or the symptoms associated with amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD), including diseases or conditions characterized by a loss of cognitive memory capacity such as, for example, mild cognitive impairment (MCI).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样样蛋白（包括淀粉样变性）引起或与之相关的疾病和病症。 特别地，本发明提供了新颖的方法和组合物，用于在生物体内，特别是能够预防或缓解淀粉样变性的动物，特别是哺乳动物或人类中引发高度特异性和高度有效的免疫应答，或症状 与淀粉样变性有关的一组疾病和病症，包括继发淀粉样变性和年龄相关性淀粉样变性，包括但不限于神经系统疾病如阿尔茨海默氏病（AD），包括特征在于认知丧失的疾病或病症 记忆能力，例如轻度认知障碍（MCI）。
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16.发明申请公开(公告)号：US20130190524A1
公开(公告)日：2013-07-25
申请号：US13591930
申请日：2012-08-22
申请人： Jean-Marie Lehn , Srinivasu Pothukanuri , Alexandros Koumbis , Carolina Duarte , Claude Nicolau
发明人： Jean-Marie Lehn , Srinivasu Pothukanuri , Alexandros Koumbis , Carolina Duarte , Claude Nicolau
IPC分类号： C07F9/144
CPC分类号： C07F9/144 , C07F9/093 , C07F9/6561 , C07F9/65744 , C07F9/65746
摘要： The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.
摘要翻译： 本发明涉及环磷酸的多磷酸化和焦磷酸衍生物。 更具体地说，本发明涉及肌醇的多磷酸化和焦磷酸衍生物。 本发明还涉及肌醇和其它类似的，更亲脂的衍生物的多磷酸化和焦磷酸衍生物的组合物，以及它们作为变构效应器，细胞信号分子类似物和治疗剂的用途。
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公开(公告)号：US07807175B2
公开(公告)日：2010-10-05
申请号：US11637607
申请日：2006-12-12
申请人： Andrea Pfeifer , Claude Nicolau
发明人： Andrea Pfeifer , Claude Nicolau
IPC分类号： A61K39/385 , A61K38/10
CPC分类号： A61K39/0008 , C07K16/18 , Y10S424/812
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis.In particular, the present invention provides novel methods and compositions for eliciting a highly specific and highly effective immune response in an organism, but particularly within an animal, particularly a mammal or a human, which is capable of preventing or alleviating amyloidosis, or the symptoms associated with amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD), including diseases or conditions characterized by a loss of cognitive memory capacity such as, for example, mild cognitive impairment (MCI).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样样蛋白（包括淀粉样变性）引起或与之相关的疾病和病症。 特别地，本发明提供了新颖的方法和组合物，用于在生物体内，特别是能够预防或缓解淀粉样变性的动物，特别是哺乳动物或人类中引发高度特异性和高度有效的免疫应答，或症状 与淀粉样变性有关的一组疾病和病症，包括继发淀粉样变性和年龄相关性淀粉样变性，包括但不限于神经系统疾病如阿尔茨海默氏病（AD），包括特征在于认知丧失的疾病或病症 记忆能力，例如轻度认知障碍（MCI）。
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公开(公告)号：US07772375B2
公开(公告)日：2010-08-10
申请号：US11637213
申请日：2006-12-11
申请人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
IPC分类号： C07K16/18 , C12N5/12 , A61K39/395 , A61K31/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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公开(公告)号：US20070166311A1
公开(公告)日：2007-07-19
申请号：US11637213
申请日：2006-12-11
申请人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
发明人： Ruth Greferath , David Hickman , Andreas Muhs , Andrea Pfeifer , Claude Nicolau
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , G01N2333/4709 , A61K2300/00
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供新的方法和组合物，其包含具有特异性识别和结合来自β-淀粉样蛋白范围的特异性表位的能力的高度特异性和高效抗体。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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20.发明授权Procedure for the enhancement of the resistance to arsenite and arsenate of Thiobacillus ferrooxidans and Bacillus subtilis 失效提高硫氧化硫杆菌和枯草芽孢杆菌对亚砷酸盐和砷酸盐耐药性的方法
公开(公告)号：US4716114A
公开(公告)日：1987-12-29
申请号：US719337
申请日：1985-04-03
申请人： Claude Nicolau , Jacques Raimond
发明人： Claude Nicolau , Jacques Raimond
IPC分类号： C07K14/195 , C12N15/74 , C22B3/18 , C12N15/00
CPC分类号： C22B3/18 , C07K14/195 , C12N15/74 , Y02P10/234
摘要： A process for increasing the resistance of Thiobacillus ferrooxidans and Bacillus subtilis to As (III) and As (V) by plasmid transformation.
摘要翻译： 通过质粒转化将硫酸硫杆菌硫杆菌和枯草芽孢杆菌的抗性提高到As（III）和As（V）的方法。
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