公开(公告)号：US20150045312A1

公开(公告)日：2015-02-12

申请号：US14456834

申请日：2014-08-11

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  Chad Beyer

IPC: A61K31/4965 ,  A61K38/05 ,  A61K31/497

CPC classification number: A61K31/4965 ,  A61K31/497 ,  A61K38/05

Abstract: Methods of treating autism, autistic spectrum disorders or Fragile X syndrome comprised of administering molecules that engage the cystine-glutamate exchange (System xc−) and/or elevate the extracellular levels of glutathione in the CNS. Preferred compounds are cysteine/cystine prodrugs or N-acetyl cysteine (NAC) prodrugs.

Abstract translation: 治疗自闭症，自闭症谱系障碍或脆性X综合征的方法包括施用与胱氨酸 - 谷氨酸交换（系统xc-）接合的分子和/或提高CNS中谷胱甘肽的细胞外水平。 优选的化合物是半胱氨酸/胱氨酸前药或N-乙酰半胱氨酸（NAC）前药。

公开(公告)号：US10961187B2

公开(公告)日：2021-03-30

申请号：US16443793

申请日：2019-06-17

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC: C07C327/34 ,  C07C323/60 ,  C07D277/14 ,  C07C327/26 ,  C07D277/08 ,  C07C327/32 ,  C07C329/06 ,  C07C323/59 ,  C07C323/58 ,  C07C323/57 ,  C07D241/08 ,  C07D327/04 ,  A61K31/265 ,  A61K31/165 ,  A61K31/426 ,  A61K31/513

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US10358414B2

公开(公告)日：2019-07-23

申请号：US15481728

申请日：2017-04-07

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC: C07D277/08 ,  C07D241/08 ,  C07C323/60 ,  C07C327/26 ,  C07C329/06 ,  C07C327/34 ,  C07D327/04 ,  C07C323/57 ,  C07C323/58 ,  C07C323/59 ,  C07C327/32 ,  C07D277/14 ,  A61K31/265 ,  A61K31/165 ,  A61K31/426 ,  A61K31/513

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers′ disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US09193681B1

公开(公告)日：2015-11-24

申请号：US14535883

申请日：2014-11-07

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  Mark A. Wolf ,  Keith D. Barnes ,  Garry Smith

IPC: A01N43/40 ,  C07C327/08

CPC classification number: C07C327/34 ,  C07C327/08 ,  C07C2601/08 ,  C07C2601/14

Abstract: The invention relates to compounds of the following formula: and their pharmaceutically acceptable salts, pharmaceutical compositions containing this compounds, and methods of using this compound for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

Abstract translation: 本发明涉及下式的化合物及其药学上可接受的盐，含有该化合物的药物组合物，以及使用该化合物治疗各种疾病或病症的方法，包括但不限于疾病和/或病症，或 涉及中枢神经系统（CNS），包括精神分裂症肾上腺脑白质营养不良，线粒体疾病（例如Leigh综合征，阿尔卑斯病和MELAS），亨廷顿舞蹈病，拔毛病，艾滋病毒相关神经认知障碍，缺氧缺血性脑病，药物渴求和药物 瘾。

公开(公告)号：US20150133470A1

公开(公告)日：2015-05-14

申请号：US14535855

申请日：2014-11-07

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC: C07D277/14 ,  C07D241/08 ,  C07C323/58 ,  C07C323/59 ,  C07C327/32 ,  C07C329/06

CPC classification number: C07D277/08 ,  A61K31/165 ,  A61K31/265 ,  A61K31/426 ,  A61K31/513 ,  C07C323/57 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C327/26 ,  C07C327/32 ,  C07C327/34 ,  C07C329/06 ,  C07D241/08 ,  C07D277/14 ,  C07D327/04

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

Abstract translation: 新型取代的N-乙酰基-L-半胱氨酸（NAC）衍生物和相关化合物以及使用这些化合物治疗疾病和/或病症的方法，包括但不限于中枢神经的疾病和/或病症或涉及中枢神经 系统（CNS），包括精神分裂症肾上腺脑白质营养不良，线粒体疾病（例如Leigh综合征，阿尔卑斯病和MELAS），亨廷顿舞蹈病，拔毛病，艾滋病毒相关神经认知障碍，缺氧缺血性脑病，药物渴求和药物成瘾。

公开(公告)号：US20130338165A1

公开(公告)日：2013-12-19

申请号：US13919768

申请日：2013-06-17

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： David A. Baker ,  Daniel G. Lawton ,  Chad Beyer ,  Michael Neary

IPC: A61K31/198

CPC classification number: A61K31/198 ,  A61K31/4965 ,  A61K31/497 ,  C07D277/14

Abstract: Methods of treating Parkinson's Disease comprising administering compounds that up-regulate cystine-glutamate exchange (system Xc−) and/or increase glutathione levels in the brain cells. Preferred compounds are cysteine/cystine prodrugs or N-acetyl cysteine (NAC) prodrugs.

Abstract translation: 治疗帕金森病的方法包括给予上调胱氨酸 - 谷氨酸交换（系统Xc-）的化合物和/或增加脑细胞中的谷胱甘肽水平。 优选的化合物是半胱氨酸/胱氨酸前药或N-乙酰半胱氨酸（NAC）前药。