公开(公告)号：US10112897B2

公开(公告)日：2018-10-30

申请号：US15459840

申请日：2017-03-15

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton

IPC: C07C327/34

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US09012674B1

公开(公告)日：2015-04-21

申请号：US14535953

申请日：2014-11-07

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton

IPC: C07C327/34 ,  A61K31/265 ,  C07C327/00

CPC classification number: C07D277/08 ,  A61K31/165 ,  A61K31/265 ,  A61K31/426 ,  A61K31/513 ,  C07C323/57 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C327/26 ,  C07C327/32 ,  C07C327/34 ,  C07C329/06 ,  C07D241/08 ,  C07D277/14 ,  C07D327/04

Abstract: A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

Abstract translation: 新型取代的N-乙酰基-L-半胱氨酸（NAC）衍生物和使用该化合物治疗疾病和/或病症的方法，包括但不限于中枢神经系统的疾病和/或病症或涉及中枢神经系统 CNS），包括精神分裂症肾上腺脑白质营养不良，线粒体疾病（例如Leigh综合征，阿尔卑斯病和MELAS），亨廷顿病，头痛性痴呆，HIV相关神经认知障碍，缺氧缺血性脑病，药物渴求和药物成瘾。

公开(公告)号：US20240059649A1

公开(公告)日：2024-02-22

申请号：US18488215

申请日：2023-10-17

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC: C07C327/34 ,  C07D327/04 ,  C07D241/08 ,  C07C323/57 ,  C07C323/60 ,  C07C323/58 ,  C07C323/59 ,  C07C327/32 ,  C07C329/06 ,  C07D277/14 ,  C07C327/26 ,  C07D277/08

CPC classification number: C07C327/34 ,  C07D327/04 ,  C07D241/08 ,  C07C323/57 ,  C07C323/60 ,  C07C323/58 ,  C07C323/59 ,  C07C327/32 ,  C07C329/06 ,  C07D277/14 ,  C07C327/26 ,  C07D277/08 ,  A61K31/265

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US20170210716A1

公开(公告)日：2017-07-27

申请号：US15481728

申请日：2017-04-07

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC: C07D277/08 ,  C07C323/60 ,  C07C327/26 ,  C07D241/08 ,  C07C329/06

CPC classification number: C07C327/34 ,  A61K31/165 ,  A61K31/265 ,  A61K31/426 ,  A61K31/513 ,  C07C323/57 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C327/26 ,  C07C327/32 ,  C07C329/06 ,  C07D241/08 ,  C07D277/08 ,  C07D277/14 ,  C07D327/04

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers′ disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US20210395194A1

公开(公告)日：2021-12-23

申请号：US17216285

申请日：2021-03-29

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC: C07C327/34 ,  C07D327/04 ,  C07D241/08 ,  C07C323/57 ,  C07C323/60 ,  C07C323/58 ,  C07C323/59 ,  C07C327/32 ,  C07C329/06 ,  C07D277/14 ,  C07C327/26 ,  C07D277/08

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US20170183303A1

公开(公告)日：2017-06-29

申请号：US15459840

申请日：2017-03-15

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton

IPC: C07C327/34

CPC classification number: C07D277/08 ,  A61K31/165 ,  A61K31/265 ,  A61K31/426 ,  A61K31/513 ,  C07C323/57 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C327/26 ,  C07C327/32 ,  C07C327/34 ,  C07C329/06 ,  C07D241/08 ,  C07D277/14 ,  C07D327/04

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US09630937B2

公开(公告)日：2017-04-25

申请号：US14535855

申请日：2014-11-07

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC: A61K31/265 ,  C07D277/14 ,  C07D241/08 ,  C07C323/58 ,  C07C323/59 ,  C07C323/57 ,  C07C327/04 ,  C07C327/34 ,  C07C327/32 ,  C07C329/06 ,  C07D327/04 ,  C07C323/60

CPC classification number: C07D277/08 ,  A61K31/165 ,  A61K31/265 ,  A61K31/426 ,  A61K31/513 ,  C07C323/57 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C327/26 ,  C07C327/32 ,  C07C327/34 ,  C07C329/06 ,  C07D241/08 ,  C07D277/14 ,  C07D327/04

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US20190315683A1

公开(公告)日：2019-10-17

申请号：US16443793

申请日：2019-06-17

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton ,  Garry Smith

IPC: C07C327/34 ,  C07C323/60 ,  C07D277/14 ,  C07C327/26 ,  C07D277/08 ,  C07C327/32 ,  C07C329/06 ,  C07C323/59 ,  C07C323/58 ,  C07C323/57 ,  C07D241/08 ,  C07D327/04

Abstract: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

公开(公告)号：US20150344419A1

公开(公告)日：2015-12-03

申请号：US14535883

申请日：2014-11-07

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  Mark A. Wolf ,  Keith D. Barnes ,  Garry Smith

IPC: C07C327/08

CPC classification number: C07C327/34 ,  C07C327/08 ,  C07C2601/08 ,  C07C2601/14

Abstract: The invention relates to compounds of the following formula: and their pharmaceutically acceptable salts, pharmaceutical compositions containing this compounds, and methods of using this compound for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

Abstract translation: 本发明涉及下式的化合物及其药学上可接受的盐，含有该化合物的药物组合物，以及使用该化合物治疗各种疾病或病症的方法，包括但不限于疾病和/或病症，或 涉及中枢神经系统（CNS），包括精神分裂症肾上腺脑白质营养不良，线粒体疾病（例如Leigh综合征，阿尔卑斯病和MELAS），亨廷顿舞蹈病，拔毛病，艾滋病毒相关神经认知障碍，缺氧缺血性脑病，药物渴求和药物 瘾。

公开(公告)号：US20150133544A1

公开(公告)日：2015-05-14

申请号：US14535953

申请日：2014-11-07

Applicant: Promentis Pharmaceuticals, Inc.

Inventor： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton

IPC: C07C327/34

CPC classification number: C07D277/08 ,  A61K31/165 ,  A61K31/265 ,  A61K31/426 ,  A61K31/513 ,  C07C323/57 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C327/26 ,  C07C327/32 ,  C07C327/34 ,  C07C329/06 ,  C07D241/08 ,  C07D277/14 ,  C07D327/04

Abstract: A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

Abstract translation: 新型取代的N-乙酰基-L-半胱氨酸（NAC）衍生物和使用该化合物治疗疾病和/或病症的方法，包括但不限于中枢神经系统的疾病和/或病症或涉及中枢神经系统 CNS），包括精神分裂症肾上腺脑白质营养不良，线粒体疾病（例如Leigh综合征，阿尔卑斯病和MELAS），亨廷顿病，头痛性痴呆，HIV相关神经认知障碍，缺氧缺血性脑病，药物渴求和药物成瘾。