利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

15 条记录 (耗时 0.015 秒)

    Propionic acids, propionic acid esters, and related compounds
    1.
    发明授权
    Propionic acids, propionic acid esters, and related compounds 有权
    丙酸，丙酸酯和相关化合物

    公开(公告)号：US09193681B1

    公开(公告)日：2015-11-24

    申请号：US14535883

    申请日：2014-11-07

    申请人： Promentis Pharmaceuticals, Inc.

    发明人： Michael Neary ,  Mark A. Wolf ,  Keith D. Barnes ,  Garry Smith

    IPC分类号： A01N43/40 ,  C07C327/08

    CPC分类号： C07C327/34 ,  C07C327/08 ,  C07C2601/08 ,  C07C2601/14

    摘要： The invention relates to compounds of the following formula: and their pharmaceutically acceptable salts, pharmaceutical compositions containing this compounds, and methods of using this compound for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

    摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，含有该化合物的药物组合物，以及使用该化合物治疗各种疾病或病症的方法，包括但不限于疾病和/或病症，或 涉及中枢神经系统（CNS），包括精神分裂症肾上腺脑白质营养不良，线粒体疾病（例如Leigh综合征，阿尔卑斯病和MELAS），亨廷顿舞蹈病，拔毛病，艾滋病毒相关神经认知障碍，缺氧缺血性脑病，药物渴求和药物 瘾。

    PROPIONIC ACIDS, PROPIONIC ACID ESTERS, AND RELATED COMPOUNDS
    6.
    发明申请
    PROPIONIC ACIDS, PROPIONIC ACID ESTERS, AND RELATED COMPOUNDS 有权
    丙酸，丙酸酯及相关化合物

    公开(公告)号：US20150344419A1

    公开(公告)日：2015-12-03

    申请号：US14535883

    申请日：2014-11-07

    申请人： Promentis Pharmaceuticals, Inc.

    发明人： Michael Neary ,  Mark A. Wolf ,  Keith D. Barnes ,  Garry Smith

    IPC分类号： C07C327/08

    CPC分类号： C07C327/34 ,  C07C327/08 ,  C07C2601/08 ,  C07C2601/14

    摘要： The invention relates to compounds of the following formula: and their pharmaceutically acceptable salts, pharmaceutical compositions containing this compounds, and methods of using this compound for the treatment of various diseases or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

    摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐，含有该化合物的药物组合物，以及使用该化合物治疗各种疾病或病症的方法，包括但不限于疾病和/或病症，或 涉及中枢神经系统（CNS），包括精神分裂症肾上腺脑白质营养不良，线粒体疾病（例如Leigh综合征，阿尔卑斯病和MELAS），亨廷顿舞蹈病，拔毛病，艾滋病毒相关神经认知障碍，缺氧缺血性脑病，药物渴求和药物 瘾。

    Method for producing carboxylic acid thioester
    7.
    发明授权
    Method for producing carboxylic acid thioester 有权

    公开(公告)号：US10377706B2

    公开(公告)日：2019-08-13

    申请号：US15988300

    申请日：2018-05-24

    申请人： Mitsubishi Chemical Corporation

    发明人： Akihiro Goto

    IPC分类号： C07C327/06 ,  C07C327/22 ,  C07C327/24 ,  C07C327/26 ,  C07C327/32 ,  C07D213/70 ,  C07C327/08 ,  C07D277/74 ,  C07B61/00

    摘要： According to the present invention, there is provided a method for producing carboxylic acid thioester, comprising reacting a compound represented by the following formula (I), carboxylic acid and thiol in the presence of a catalyst including at least one Group 2 metal compound. The production method is a production method which is simple in reaction operation, which places a small load on the environment and the human body and which enables carboxylic acid thioester to be catalytically obtained at a high yield even at a normal temperature and a normal pressure (25° C., 1 atm). In the formula (I), R1 and R2 each independently represent a hydrocarbon group having 1 to 20 carbon atoms.

    COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
    8.
    发明申请
    COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 审中-公开
    用于治疗代谢性疾病的化合物

    公开(公告)号：US20110166233A1

    公开(公告)日：2011-07-07

    申请号：US13034201

    申请日：2011-02-24

    申请人： Shalini Sharma ,  Reid W. Von Borstel

    发明人： Shalini Sharma ,  Reid W. Von Borstel

    IPC分类号： A61K31/192 ,  C07C327/08 ,  A61P3/10 ,  A61P3/04 ,  A61P3/06 ,  A61P9/10

    CPC分类号： A61K31/185 ,  C07C327/12

    摘要： Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0, 1, 2, 3, or 4; q is 0 or 1; t is 0 or 1; R1 is alkyl having from 1 to 3 carbon atoms; R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; one of R3 and R4 is hydrogen or hydroxy and the other is hydrogen; or R3 and R4 together are ═O; R5 is hydrogen or alkyl having one, two, three, four or five carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon. Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of Formula I.

    摘要翻译： 公开了可用于治疗各种代谢紊乱（例如胰岛素抵抗综合征，糖尿病，多囊卵巢综合征，高脂血症，脂肪肝疾病，恶病质，肥胖症，动脉粥样硬化和动脉硬化）的药剂。 其中n为1或2; m为0,1,2,3或4; q为0或1; t为0或1; R1是具有1至3个碳原子的烷基; R2是氢，卤素，具有1至3个碳原子的烷基或具有1至3个碳原子的烷氧基; R3和R4之一是氢或羟基，另一个是氢; 或R3和R4一起为= O; R5是氢或具有一个，两个，三个，四个或五个碳原子的烷基; A是未取代的或被1或2个选自：卤素，羟基，具有1或2个碳原子的烷基，全氟甲基，具有1或2个碳原子的烷氧基和全氟甲氧基取代的苯基; 或具有3至6个环碳原子的环烷基，其中环烷基是未取代的或一个或两个环碳独立地被甲基或乙基单取代; 或具有1或2个选自N，S和O的环杂原子的5或6元杂芳环，杂芳环通过环碳与式I化合物的其余部分共价结合。 或者，该试剂可以是式I化合物的药学上可接受的盐。