公开(公告)号：US20100173403A1

公开(公告)日：2010-07-08

申请号：US12729688

申请日：2010-03-23

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: C12M3/06

CPC classification number: C12N5/0087

Abstract: A method of “non-isopycnic” cell isolation and purification has the steps of adding a sample of blood to a defined volume to a corresponding ratio volume of EDTA solution to produce a volume of anti-coagulated blood; taking a predetermined volume of the anti-coagulated blood and placing it in a first tube containing a selected defined volume of PSS, wherein the selected defined volume of PSS is taken from a group of defined volumes of PSS, as each defined volume of PSS establishes a specific cell type to be purified; centrifuging the tube for a first predetermined time and speed to form a volume of supernatant of plasma/PSS and a bottom sedimented volume of mostly red blood cells; extracting the supernatant to within a proximity of an interface between the sedimented red blood cells and the supernatant; transferring an appropriate, pre-selected volume amount of the supernatant into a second tube holding a defined volume of physiological media; mixing the solutions gently; centrifuging for a second predetermined speed and time; and pouring off the supernatant wherein at the bottom of the tube will be a cell button containing a volume of the selected purified cells in a high percentage and a very small quantity or low percentage of some contaminating non-selected cells. This method is useful in establishing high purity concentrations of selected cells from whole blood such as monocytes, lymphocytes, neutrophils and basophils.

Abstract translation: “非等同生物”细胞分离和纯化的方法具有以下步骤：将规定体积的血液样品加入到相应的EDTA溶液体积中以产生一定体积的抗凝血液; 取预定体积的抗凝血液并将其置于含有选定的定义体积的PSS的第一管中，其中所选定义体积的PSS取自一组定义体积的PSS，因为每个确定的PSS体积建立 要纯化的特定细胞类型; 将管离心第一预定时间和速度以形成血浆/ PSS的上清液体积和主要为红细胞的底部沉积体积; 将上清液提取到沉淀的红细胞与上清液之间的界面附近; 将适当的预先选定体积的上清液转移到保持限定体积的生理介质的第二管中; 轻轻混合溶液; 离心第二预定速度和时间; 并倒出上清液，其中在管的底部将是含有一定体积的所选纯化细胞的细胞按钮，其中高纯度的细胞和非常少量或低百分比的一些污染性未选择的细胞。 该方法可用于从全血如单核细胞，淋巴细胞，嗜中性粒细胞和嗜碱性粒细胞中建立高纯度浓度的选定细胞。

公开(公告)号：US07727764B2

公开(公告)日：2010-06-01

申请号：US11616999

申请日：2006-12-28

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: C12N5/071 ,  C12N5/02

CPC classification number: C12N5/0087

Abstract: A method of “non-isopycnic” cell isolation and purification has the steps of adding a sample of blood to a defined volume to a corresponding ratio volume of EDTA solution to produce a volume of anti-coagulated blood; taking a predetermined volume of the anti-coagulated blood and placing it in a first tube containing a selected defined volume of PSS, wherein the selected defined volume of PSS is taken from a group of defined volumes of PSS, as each defined volume of PSS establishes a specific cell type to be purified; centrifuging the tube for a first predetermined time and speed to form a volume of supernatant of plasma/PSS and a bottom sedimented volume of mostly red blood cells; extracting the supernatant to within a proximity of an interface between the sedimented red blood cells and the supematant; transferring an appropriate, pre-selected volume amount of the supernatant into a second tube holding a defined volume of physiological media; mixing the solutions gently; centrifuging for a second predetermined speed and time; and pouring off the supernatant wherein at the bottom of the tube will be a cell button containing a volume of the selected purified cells in a high percentage and a very small quantity or low percentage of some contaminating non-selected cells. This method is useful in establishing high purity concentrations of selected cells from whole blood such as monocytes, lymphocytes, neutrophils and basophils.

Abstract translation: “非等同生物”细胞分离和纯化的方法具有以下步骤：将规定体积的血液样品加入到相应的EDTA溶液体积中以产生一定体积的抗凝血液; 取预定体积的抗凝血液并将其置于含有选定的定义体积的PSS的第一管中，其中所选定义体积的PSS取自一组定义体积的PSS，因为每个确定的PSS体积建立 要纯化的特定细胞类型; 将管离心第一预定时间和速度以形成血浆/ PSS的上清液体积和主要为红细胞的底部沉积体积; 将上清液提取到沉淀的红细胞和上清液之间的界面附近; 将适当的预先选定体积的上清液转移到保持限定体积的生理介质的第二管中; 轻轻混合溶液; 离心第二预定速度和时间; 并倒出上清液，其中在管的底部将是含有一定体积的所选纯化细胞的细胞按钮，其中高纯度的细胞和非常少量或低百分比的一些污染性未选择的细胞。 该方法可用于从全血如单核细胞，淋巴细胞，嗜中性粒细胞和嗜碱性粒细胞中建立高纯度浓度的选定细胞。

公开(公告)号：US20090017743A1

公开(公告)日：2009-01-15

申请号：US11775941

申请日：2007-07-11

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: B60S1/02

CPC classification number: B60S1/54

Abstract: An air flow device for generating an air flow 30 across a windshield 4 of a vehicle 2, the air flow device has one or more means 10 for generating an air flow 32 located in proximity on a lateral end or side of the windshield 4, the one or more means 10 for generating an air flow 30 directs the flow of air laterally onto the windshield 4. The one or more means 10 for generating an air flow 30 has one or more fans 20 rotatable about an axis 22. Each fan 20 has a plurality of fan blades 24 for intaking air near the axis of rotation 22 of the fan blade 24, the fan blades 24 extend longitudinally having a cross section of increasing curvature to a substantially flattened unshaped terminal end 24E for directing the air flow 30 laterally. The one or more fans 20 can be driven by a single motor 25. Alternatively, each fan 20 may include a motor 25 for driving the fan blade 24.

Abstract translation: 一种用于在车辆2的挡风玻璃4上产生空气流30的空气流动装置，空气流动装置具有一个或多个装置10，用于产生位于挡风玻璃4的侧面或侧面附近的气流32， 用于产生空气流30的一个或多个装置10将空气流横向地引导到挡风玻璃4上。用于产生空气流30的一个或多个装置10具有可绕轴线22旋转的一个或多个风扇20.每个风扇20具有 用于在风扇叶片24的旋转轴线22附近吸入空气的多个风扇叶片24，风扇叶片24纵向延伸，具有增加的曲率的横截面，以基本上扁平的未形状的未形状的终端24E，用于横向引导空气流30。 一个或多个风扇20可以由单个电动机25驱动。或者，每个风扇20可以包括用于驱动风扇叶片24的电动机25。

公开(公告)号：US20220241147A1

公开(公告)日：2022-08-04

申请号：US17162372

申请日：2021-01-29

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: A61H31/00 ,  A61H23/06

Abstract: A simplified method of clearing a blockage caused by an obstruction in a person who is choking has the steps of standing the choking person behind a seat back of a chair, doubling the choking person over the seat back thereby having the choking person's head and chest pointing straight downwardly, and striking a back of the choking person repeatedly to drive the obstruction downwardly out of the throat towards the mouth of the choking person under the assistance of gravity to clear the obstruction. The method may further include the step of pressing the choking person's abdomen against the top of the seat back.

公开(公告)号：US10398628B2

公开(公告)日：2019-09-03

申请号：US15692734

申请日：2017-08-31

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: A61J7/00 ,  B26D3/30 ,  B26D7/01 ,  B26D5/10 ,  A61J3/06 ,  B26D1/08

Abstract: A multiple pill cutting device has a pivoting housing structure holding a blade holding assembly. The pivoting housing structure has a top housing pivotably connected at one end to a bottom housing. The bottom housing has a plurality of pill holding openings arranged in one or more rows. The one or more rows of pill holding openings have a slotted channel extending along a length of the bottom housing through and bisecting each pill holding opening. The blade holding assembly has one or more extending cutting blades. One blade is configured to align with each slotted channel when the top housing pivots closing onto the bottom housing, this moves the one or more cutting blades of the blade holding assembly to enter the slotted channels and cut pills held in the pill holding openings.

公开(公告)号：US08938890B2

公开(公告)日：2015-01-27

申请号：US13303875

申请日：2011-11-23

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: A43B7/14 ,  A43B3/26 ,  A43B23/07 ,  A43B5/00 ,  A43B7/28 ,  A43B23/28 ,  A43B23/04 ,  A43B21/06 ,  A43B23/02 ,  A43B1/00 ,  A43B3/00 ,  A43B3/30 ,  A43B5/04 ,  A63C17/00

CPC classification number: A43B7/14 ,  A43B1/0072 ,  A43B3/0063 ,  A43B3/0078 ,  A43B3/26 ,  A43B3/30 ,  A43B5/00 ,  A43B5/0405 ,  A43B7/28 ,  A43B21/06 ,  A43B23/0265 ,  A43B23/0295 ,  A43B23/047 ,  A43B23/07 ,  A43B23/28 ,  A63C17/0086

Abstract: An expandable shoe has a top portion, a pair of side portions, a back portion, a sole, a heel and a first elastic member. The first elastic member joins the top portion to the pair of side portions at a critical location which is at the junction of the top portion and the side portions. The first elastic member is in the shape of an inverted “U” extending along the front of the shoe. The expandable shoe may further have a second elastic member joining the back portion to the side portions at the critical locations at the junctions of the back and side portions and the junctions of the back and the rear of the sole. The second elastic member is in the shape of an upright “U”.

Abstract translation: 可膨胀靴具有顶部，一对侧部，后部，鞋底，跟部和第一弹性构件。 第一弹性构件在位于顶部和侧部的接合处的临界位置处将顶部连接到一对侧部。 第一弹性构件是沿着鞋的前部延伸的倒U形的形状。 可膨胀的鞋还可以具有第二弹性构件，该第二弹性构件将鞋底的后部和后部的后部和侧部的接合处的接合处的关键位置处的后部连接到侧部。 第二弹性构件呈直立的“U”形状。

公开(公告)号：US20140075677A1

公开(公告)日：2014-03-20

申请号：US13621888

申请日：2012-09-18

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: A47G9/10

CPC classification number: A47G9/1027 ,  A47G9/1081

Abstract: The neck supporting pillow with some special features: inflatable, this will give complete control over firmness, soft sponge-like material on the outside, to make the contact points soft, neck-support part is like a ridge, approximate width of the curvature of the neck. Anterior convexity of this neck supporting ridge is the most important feature. When the user lies on his or her back, back of the head will slide into a center head rest recess. This completes the anatomical-specific features. On either side of the head-rest recess is a slightly raised area to rest face on lying-on the right or left side.

Abstract translation: 颈部支撑枕头有一些特点：充气，这样可以完全控制坚固度，软海绵状材料在外面，使接触点柔软，颈部支撑部分像脊，近似宽度的曲率 颈部。 这个颈支撑脊的前凸是最重要的特征。 当用户躺在他或她的背部时，头部的后面将滑入中央头枕座。 这完成了解剖特征。 头枕休息区的任一侧是躺在右侧或左侧的略微抬高的面部，以放置在脸部。

公开(公告)号：US20120202168A1

公开(公告)日：2012-08-09

申请号：US13185563

申请日：2011-07-19

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: A61C17/00

CPC classification number: A61C19/063

Abstract: An improved dental hygiene device for wearing in the mouth over the teeth and along gums has a flexible open-support structure. The flexible open-support structure has two opposing facing bases, an inner base and an outer base. Each base extends the length of the device and has a curvature to fit over the teeth and along gums of a wearer of the device. The inner base fits between teeth and the tongue, while the outer base fits between the teeth and the cheeks and lips region of the mouth. A plurality of arch-shaped ribs extends from the inner base over to the outer base joining the two bases to form the flexible open-support structure. The support structure has a means for receiving and holding a cream or paste and delivering the cream or paste to the teeth and gums. The cream or paste is automatically wetted by the production of saliva allowing the cream or paste to wick and migrate into the mouth.

Abstract translation: 改进的牙齿清洁装置具有柔软的开放支撑结构，用于在牙齿上和口齿上佩戴口腔。 柔性开放支撑结构具有两个相对的对置基部，内部基部和外部基部。 每个基部延伸装置的长度，并且具有曲率以配合在齿上并沿着装置的使用者的牙龈。 内部基座适合于牙齿和舌头之间，而外部基座适合于牙齿与嘴唇的脸颊和嘴唇区域之间。 多个拱形肋从内部基部延伸到连接两个基部的外部基座，以形成柔性开放支撑结构。 支撑结构具有用于接收和保持奶油或糊状物并将奶油或糊剂递送到牙齿和牙龈的装置。 奶油或糊状物通过产生唾液而自动润湿，从而使奶油或糊状物吸收并移入口中。

公开(公告)号：US08156933B2

公开(公告)日：2012-04-17

申请号：US11425533

申请日：2006-06-21

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: A61M11/00 ,  B05B17/06

CPC classification number: A61M15/0065 ,  A61M11/001 ,  A61M11/005 ,  A61M15/0016 ,  A61M15/0021 ,  A61M15/0085 ,  A61M2202/064 ,  A61M2205/8206 ,  A61M2205/8237

Abstract: A nebulizer apparatus according to the present invention has an enclosure including a primary chamber of ambient air, a medicant chamber and a secondary chamber. The secondary chamber is for containing water and includes an ultrasonic transducer and is in communication with the primary chamber. The apparatus further has a first switch for activating pump means for evacuating air from the primary chamber after which the transducer is activated for a predetermined time. The pump stops after a predetermined pressure is achieved. The apparatus has a valve that opens allowing a dose of powdered medicine in the medicant chamber to move into the vapor-rich primary chamber to seed and form a cloud laden with medicine. A mouthpiece is attached to said primary chamber to allow the patient to suck and inhale the cloud. The mouthpiece may further include a one way valve that seals the mouthpiece during evacuation and upon the patient sucking the tubing of the mouthpiece the valve opens to allow the cloud to be inhaled.

Abstract translation: 根据本发明的喷雾器装置具有包括环境空气的主室，药剂室和次室的外壳。 次级室用于容纳水并且包括超声换能器并与主室连通。 该装置还具有用于启动泵装置的第一开关，用于从主室排出空气，在此之后，传感器被激活预定时间。 达到预定压力后，泵停止。 该装置具有打开的阀门，允许药剂室中的粉末药物的量移动到富蒸气的初级室中以种植并形成充满药物的云。 吸嘴连接到所述主室以允许患者吸入和吸入云。 接口还可以包括单向阀，其在抽空期间密封接口管，并且在患者吸入接口管的管道时，阀打开以允许云被吸入。

公开(公告)号：US20090051314A1

公开(公告)日：2009-02-26

申请号：US11842439

申请日：2007-08-21

Applicant: Puthalath Koroth Raghuprasad

Inventor： Puthalath Koroth Raghuprasad

IPC: H02J7/14

CPC classification number: H02K53/00

Abstract: A power generation apparatus 100 has a moving permanent magnet 10 having a north polarity (N) at a first end 11 and a south polarity (S) at an opposite second end 12; a pair of electromagnets 20,22 are positioned with one being in proximity to each end 11,12 of the moving permanent magnet 10. Each electromagnet 20, 22 has a coil 25, 26 wrapped around a central iron core 27, 28. When activated the electromagnets 20, 22 provide a repulsive force of the same polarity as the nearest respective end 11 or 12 of the permanent magnet 10. The apparatus 100 further has one or more switches 32, 33 for activating each electromagnet 20, 22 and a central coil 40 encircling the permanent magnet 10 and a battery 50 connected to the central coil 40. Within the central core 40 the permanent magnet 10 is moving repeatedly toward each electromagnet 20 and 22 and as the N or S end of the magnet 10 approaches the electromagnet 20 or 22 of the same polarity the one or more switches 32, 33 turns the closest electromagnetic coil 25 or 26 on creating a repulsive electromagnetic field pushing the magnet 10 in an opposite direction towards the opposite electromagnet 20 or 22. These movements also switch power off of the one electromagnet 20 or 22 and thereafter switching the power on of the opposite electromagnet 20 or 22 creating a repulsive magnetic field to push the magnet 10 in a returning opposite direction. Each movement of the magnet 10 generates an electric current in the central coil 40 to power a light 30 used to activate the switches 32, 33 and to charge the battery 50 while any excess electricity generated can be used to power other devices.

Abstract translation: 发电装置100具有在第一端11具有北极性（N）的移动永磁体10和在相对的第二端12处的南极性（S） 一对电磁体20,22被定位成一个靠近移动永磁体10的每个端部11,12。每个电磁体20,22具有围绕中心铁芯27,28缠绕的线圈25,26。当被激活时 电磁体20,22提供与永磁体10的最近的相应端11或12具有相同极性的排斥力。装置100还具有一个或多个用于激活每个电磁体20,22的开关32,33和一个中心线圈 环绕永磁体10和连接到中心线圈40的电池50.在中心芯40内，永磁体10朝向每个电磁体20和22重复移动，并且随着磁体10的N或S端接近电磁体20 或22相同的极性，一个或多个开关32,33在产生排斥电磁场时转动最近的电磁线圈25或26，以推动磁体10朝向相对电磁体20或22的相反方向。 这些运动也切断一个电磁体20或22的电源，然后切换相对电磁体20或22的电源，产生排斥磁场，以推动磁体10返回相反的方向。 磁体10的每个运动在中心线圈40中产生电流，以对用于启动开关32,33的光30供电，并且在产生的任何多余的电力可以用于为其他装置供电的同时为电池50充电。