公开(公告)号：US10717755B2

公开(公告)日：2020-07-21

申请号：US16265256

申请日：2019-02-01

申请人： Reata Pharmaceuticals, Inc.

发明人： Xin Jiang ,  John Allen Walling ,  Melanie J. Bevill ,  Christopher S. Seadeek ,  Jared P. Smit

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/207 ,  A61P3/10 ,  C07H1/06 ,  A61P25/02 ,  A61K31/7048

摘要： Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20190241599A1

公开(公告)日：2019-08-08

申请号：US16265256

申请日：2019-02-01

申请人： Reata Pharmaceuticals, Inc.

发明人： Xin Jiang ,  John Allen Walling ,  Melanie J. Bevill ,  Christopher S. Seadeek ,  Jared P. Smit

IPC分类号： C07H15/207 ,  A61P3/10 ,  A61P25/02 ,  C07H1/06

摘要： Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US10093614B2

公开(公告)日：2018-10-09

申请号：US15615393

申请日：2017-06-06

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric Anderson ,  Xin Jiang ,  Melean Visnick

IPC分类号： C07C255/47 ,  C07C271/24 ,  C07C275/26 ,  C07C311/07 ,  C07D209/56 ,  C07D211/44 ,  C07D261/08 ,  C07J63/00 ,  C07C311/09 ,  C07D231/12 ,  C07D295/195 ,  C07D307/20 ,  C07D487/08

摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

公开(公告)号：US09174941B2

公开(公告)日：2015-11-03

申请号：US13939818

申请日：2013-07-11

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric Anderson ,  Gary L. Bolton ,  Bradley Caprathe ,  Xin Jiang ,  Chitase Lee ,  William H. Roark ,  Melean Visnick

IPC分类号： C07D231/54 ,  C07D239/70 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D487/04

CPC分类号： C07C255/47 ,  C07D231/54 ,  C07D239/70 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D487/04

摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.

摘要翻译： 本文公开了新型抗氧化剂炎症调节剂，包括下式的那些：其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用该化合物及其组合物的方法。

公开(公告)号：US20150148384A1

公开(公告)日：2015-05-28

申请号：US14406854

申请日：2013-06-14

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric Anderson ,  Christopher F. Bender ,  Xin Jiang ,  Xiaofeng Liu ,  Haizhou Sun ,  Melean Visnick

IPC分类号： C07J71/00

CPC分类号： C07J71/001 ,  A61K31/336 ,  C07D493/22 ,  C07J63/008 ,  C07J75/00

摘要： Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided.

摘要翻译： 本文公开了新型的A环环氧化三萜化合物及其衍生物，包括式（I）的那些，其中变量在本文中定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品。 还提供了可用于制备化合物的方法和中间体，以及使用化合物的方法，例如抗氧化剂炎症调节剂及其组合物。

公开(公告)号：US20240043465A1

公开(公告)日：2024-02-08

申请号：US18168495

申请日：2023-02-13

申请人： Reata Pharmaceuticals, Inc.

发明人： Xin Jiang ,  John Allen Walling ,  Melanie J. Bevill ,  Christopher S. Seadeek ,  Jared P. Smit

IPC分类号： C07H15/207 ,  A61P3/10 ,  C07H1/06 ,  A61P25/02 ,  A61K31/7048

CPC分类号： C07H15/207 ,  A61P3/10 ,  C07H1/06 ,  A61P25/02 ,  A61K31/7048 ,  C07B2200/13

摘要： Disclosed are co-crystal forms of N-(2-(5-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetra-hydro-2H-pyran-2-yl)oxy)-3′-fluoro-[1,1′-biphenyl]-2-yl)ethyl)-acetamide and L-proline or D-proline, their pharmaceutical compositions, processes of manufacture, and methods of use for treating neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US11814338B2

公开(公告)日：2023-11-14

申请号：US17457808

申请日：2021-12-06

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric Anderson ,  Gary L. Bolton ,  Bradley Caprathe ,  Xin Jiang ,  Chitase Lee ,  William H. Roark ,  Melean Visnick

IPC分类号： C07D231/54 ,  C07C255/47 ,  C07D239/70 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D487/04 ,  C07D413/04

CPC分类号： C07C255/47 ,  C07D231/54 ,  C07D239/70 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D487/04

摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula:




wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.

公开(公告)号：US11584775B2

公开(公告)日：2023-02-21

申请号：US15760662

申请日：2016-09-23

申请人： REATA PHARMACEUTICALS, INC.

发明人： Melean Visnick ,  Xin Jiang ,  Martha R. Hotema ,  Chitase Lee ,  Bradley William Caprathe ,  William H. Roark ,  Gary L. Bolton

IPC分类号： C07J63/00 ,  C07J71/00 ,  A61P29/00

摘要： Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions of these derivatives or analogs, methods for their manufacture, and methods for their use, including for the prevention and treatment of diseases or disorders associated with overproduction of IL-17.

公开(公告)号：US10556858B2

公开(公告)日：2020-02-11

申请号：US16115028

申请日：2018-08-28

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric Anderson ,  Xin Jiang ,  Melean Visnick

IPC分类号： C07C271/24 ,  C07C275/26 ,  C07D307/20 ,  C07D211/44 ,  C07D231/12 ,  C07D295/195 ,  C07C275/34 ,  C07C255/47 ,  C07J63/00 ,  C07C311/09 ,  C07D261/08 ,  C07D487/08 ,  C07C311/07 ,  C07D209/56

摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

公开(公告)号：US09670147B2

公开(公告)日：2017-06-06

申请号：US14753297

申请日：2015-06-29

申请人： REATA PHARMACEUTICALS, INC.

发明人： Eric Anderson ,  Xin Jiang ,  Melean Visnick

IPC分类号： C07C255/47 ,  C07C271/24 ,  C07C275/26 ,  C07C311/07 ,  C07D209/56 ,  C07D211/44 ,  C07D231/12 ,  C07D261/08 ,  C07J63/00 ,  C07C311/09 ,  C07D307/20 ,  C07D487/08 ,  C07D295/195

CPC分类号： C07C255/47 ,  C07C271/24 ,  C07C275/26 ,  C07C311/07 ,  C07C311/09 ,  C07C2603/52 ,  C07D209/56 ,  C07D211/44 ,  C07D231/12 ,  C07D261/08 ,  C07D295/195 ,  C07D307/20 ,  C07D487/08 ,  C07J63/008

摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.