公开(公告)号：US20210085760A1

公开(公告)日：2021-03-25

申请号：US17118395

申请日：2020-12-10

申请人： Regents of the University of Minnesota ,  REGENXBIO Inc

发明人： R. Scott McIvor ,  Lalitha R. Belur ,  Walter Low ,  Carolyn Fairbanks ,  Karen Kozarsky

IPC分类号： A61K38/47 ,  C12N15/86 ,  C12N7/00

摘要： A method to prevent, inhibit or treat one or more symptoms associated with a disease of the central nervous system by intrathecally, intracerebroventricularly or endovascularly administering a rAAV encoding a gene product associated with the disease, e.g., a mammal in which the gene product is absent or present at a reduced level relative to a mammal without the disease.

公开(公告)号：US20180099030A1

公开(公告)日：2018-04-12

申请号：US15717358

申请日：2017-09-27

申请人： Regents of the University of Minnesota ,  REGENXBIO Inc.

发明人： R. Scott McIvor ,  Lalitha R. Belur ,  Walter Low ,  Carolyn Fairbanks ,  Karen Kozarsky

IPC分类号： A61K38/47

摘要： A method to prevent, inhibit or treat one or more symptoms associated with a disease of the central nervous system by intrathecally, intracerebroventricularly or endovascularly administering a rAAV encoding a gene product associated with the disease, e.g., a mammal in which the gene product is absent or present at a reduced level relative to a mammal without the disease.

公开(公告)号：US09662377B2

公开(公告)日：2017-05-30

申请号：US15135292

申请日：2016-04-21

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Michael Raymond Olin ,  John R. Ohlfest ,  Walter Low

IPC分类号： A61K35/26 ,  A61K35/28 ,  A61K39/00 ,  C12N5/095 ,  A61K31/4375 ,  A61K31/495 ,  A61K31/573 ,  A61K35/30 ,  A61K45/06 ,  C07K16/18 ,  A61K9/00 ,  A61K31/437 ,  A61K39/39 ,  A61K41/00 ,  C07K16/30

CPC分类号： A61K39/0011 ,  A61K9/0014 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/495 ,  A61K31/573 ,  A61K35/30 ,  A61K39/39 ,  A61K41/0038 ,  A61K45/06 ,  A61K2039/5152 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/575 ,  C07K16/18 ,  C07K16/3053 ,  C12N5/0695 ,  C12N2500/90

摘要： The present invention is directed to compositions and methods for treating an animal diagnosed with Glioblastoma multiforme (GBM).

公开(公告)号：US20160263207A1

公开(公告)日：2016-09-15

申请号：US15135292

申请日：2016-04-21

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Michael Raymond Olin ,  John R. Ohlfest ,  Walter Low

IPC分类号： A61K39/00 ,  A61K41/00 ,  A61K31/495 ,  C12N5/095 ,  C07K16/30 ,  A61K9/00 ,  A61K39/39 ,  A61K31/437 ,  A61K31/573

CPC分类号： A61K39/0011 ,  A61K9/0014 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/495 ,  A61K31/573 ,  A61K35/30 ,  A61K39/39 ,  A61K41/0038 ,  A61K45/06 ,  A61K2039/5152 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/575 ,  C07K16/18 ,  C07K16/3053 ,  C12N5/0695 ,  C12N2500/90

摘要： The present invention is directed to compositions and methods for treating an animal diagnosed with Glioblastoma multiforme (GBM).

公开(公告)号：US20180036388A1

公开(公告)日：2018-02-08

申请号：US15717450

申请日：2017-09-27

申请人： Regenxbio Inc.

发明人： R. Scott McIvor ,  Lalitha R. Belur ,  Walter Low ,  Carolyn Fairbanks

IPC分类号： A61K38/47 ,  C12N15/86 ,  C12N7/00 ,  A61K48/00

CPC分类号： A61K38/47 ,  A61K48/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2750/14171 ,  C12N2830/007 ,  C12Y302/01076 ,  H05K999/99

摘要： A method to prevent, inhibit or treat one or more symptoms associated with a disease of the central nervous system by intrathecally, intracerebroventricularly or endovascularly administering a rAAV encoding a gene product associated with the disease, e.g., a mammal in which the gene product is absent or present at a reduced level relative to a mammal without the disease.