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公开(公告)号：US07479211B2
公开(公告)日：2009-01-20
申请号：US10845434
申请日：2004-05-13
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , Y10T29/49002
摘要： A method of forming a biosensor is provided in accordance with the present invention. The method includes providing a metallized electrode support substrate and a sensor support, ablating the electrode support substrate to form electrodes, coupling the sensor support substrate to the electrode support substrate, and positioning spaced-apart electrically conductive tracks across the sensor support substrate so that each track is in electrical communication with one electrode.
摘要翻译： 根据本发明提供了形成生物传感器的方法。 该方法包括提供金属化电极支撑衬底和传感器支撑件，消融电极支撑衬底以形成电极，将传感器支撑衬底连接到电极支撑衬底，以及跨越传感器支撑衬底定位间隔开的导电轨迹， 轨道与一个电极电连通。
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公开(公告)号：US06645359B1
公开(公告)日：2003-11-11
申请号：US09684257
申请日：2000-10-06
IPC分类号： G01N27327
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , Y10T29/49 , Y10T29/49002 , Y10T29/49007 , Y10T29/49117
摘要： A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.
摘要翻译： 提供了一种生物传感器，其包括具有预定反应区的板元件和邻近反应区定位的凹部。 生物传感器还包括位于反应区上的试剂。 在优选的实施方案中，凹部限定反应区的至少一部分。
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公开(公告)号：US07287318B2
公开(公告)日：2007-10-30
申请号：US10703408
申请日：2003-11-07
IPC分类号： H01R43/00
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , Y10T29/49 , Y10T29/49002 , Y10T29/49007 , Y10T29/49117
摘要： A biosensor is provided that comprises a plate element with a pre-determined reaction zone and a recess positioned adjacent to the reaction zone. The biosensor also comprises a reagent that is positioned on the reaction zone. In preferred embodiments, the recess circumscribes at least a portion of the reaction zone.
摘要翻译： 提供了一种生物传感器，其包括具有预定反应区的板元件和邻近反应区定位的凹部。 生物传感器还包括位于反应区上的试剂。 在优选的实施方案中，凹部限定反应区的至少一部分。
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公开(公告)号：US06911621B2
公开(公告)日：2005-06-28
申请号：US10338498
申请日：2003-01-08
IPC分类号： G01N33/483 , B81B1/00 , G01N27/327 , G01N27/49 , G01N33/543 , B23K26/36
CPC分类号： G01N33/5438 , G01N33/54366 , Y10T29/49002
摘要： A method of forming a biosensor is provided. The method includes providing a substrate and a cover including first and second surfaces, positioning a reagent on the substrate, carving a channel by laser ablation in the first surface, and coupling the first surface of the cover to the second surface. The channel includes a first portion having a first height and a second portion having a second height that is less than the first height.
摘要翻译： 提供了形成生物传感器的方法。 该方法包括提供基底和包括第一表面和第二表面的盖，将试剂放置在基底上，通过在第一表面中的激光烧蚀来雕刻通道，以及将盖的第一表面连接到第二表面。 通道包括具有第一高度的第一部分和具有小于第一高度的第二高度的第二部分。
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公开(公告)号：US06814843B1
公开(公告)日：2004-11-09
申请号：US09704235
申请日：2000-11-01
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a top side and a generally flat bottom side. The bottom side is coupled to the substrate to define a sealed portion and an unsealed portion. The unsealed portion cooperates with the substrate to define a channel extending across the reagent.
摘要翻译： 提供一种生物传感器，其包括基板，位于基板上的试剂，以及包括顶侧和大致平坦的底侧的盖。 底侧联接到基底以限定密封部分和未密封部分。 未密封部分与衬底配合以限定穿过试剂的通道。
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公开(公告)号：US06447657B1
公开(公告)日：2002-09-10
申请号：US09729296
申请日：2000-12-04
IPC分类号： G01N2726
CPC分类号： G01N27/3272
摘要： A biosensor is provided that includes first and second plate elements, wherein each plate elements has first and second ends and first and second lateral borders. In addition, the biosensor includes a spacer positioned to lie between the first and second plate elements so that at least a portion of the first and second plate elements cooperate with one another to form opposite walls of a capillary space. Further, the first ends and at least a portion of the lateral borders define a fluid sample-receiving portion in communication with the capillary space. Electrodes are positioned in the capillary space of the biosensor.
摘要翻译： 提供了包括第一和第二板元件的生物传感器，其中每个板元件具有第一和第二端以及第一和第二横向边界。 此外，生物传感器包括定位成位于第一和第二板元件之间的间隔件，使得第一和第二板元件的至少一部分彼此配合以形成毛细管空间的相对壁。 此外，第一端部和横向边界的至少一部分限定了与毛细管空间连通的流体样品接收部分。 电极位于生物传感器的毛细管空间中。
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公开(公告)号：US08506775B2
公开(公告)日：2013-08-13
申请号：US10872008
申请日：2004-06-18
申请人： Nigel Anthony Surridge , Paul Douglas Walling , Melani Sullivan , Vladimir Svetnik , Brian S. Hill
发明人： Nigel Anthony Surridge , Paul Douglas Walling , Melani Sullivan , Vladimir Svetnik , Brian S. Hill
IPC分类号： C12M1/00
CPC分类号： C12M1/00 , C12Q1/001 , G01N27/3272
摘要： A system for testing for analytes in a sample of biological fluid includes a test strip that defines a cavity for receiving the sample. At least two sets of electrodes are adjacent the sample cavity, including one for measuring one property of the sample, and another for measuring one or more other properties of the sample, such as temperature and/or the presence or magnitude of confounding variables. The measurements are combined to yield the desired result. At least one set of working and counter electrodes each have a plurality of elongated “fingers” interdigitated with those of the other electrode in the set. The gaps between fingers can be quite small, so that the two electrode sets together can operate in a small measurement volume of sample. Additional electrodes can be included that measure the presence or sufficiency of the sample, and additional traces on the strip can act as configuration identifiers.
摘要翻译： 用于测试生物流体样品中分析物的系统包括限定用于接收样品的空腔的测试条。 至少两组电极与样品腔相邻，包括一个用于测量样品的一个性质，另一组用于测量样品的一个或多个其他性质，如温度和/或混杂变量的存在或大小。 将测量结合以产生期望的结果。 至少一组工作电极和对电极各自具有与组中的另一电极的那些相互指向的多个细长“指状物”。 手指之间的间隙可以相当小，使得两个电极组合在一起可以在小的测量体积的样品中操作。 可以包括测量样品的存在或充分性的附加电极，并且条带上的附加痕迹可以用作配置标识符。
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公开(公告)号：US06488828B1
公开(公告)日：2002-12-03
申请号：US09620191
申请日：2000-07-20
IPC分类号： G01N27327
CPC分类号： B01L3/5023 , B01L2200/082 , B01L2300/043 , B01L2300/046 , B01L2300/047 , B01L2300/0825 , B01L2300/0887 , B01L2300/105 , B01L2400/0406 , G01N33/52
摘要： A recloseable biosensor is provided that comprises a substrate, a sample site positioned on the substrate, and an openable and recloseable cover coupled to the substrate. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.
摘要翻译： 提供了一种可重新开关的生物传感器，其包括衬底，位于衬底上的样品位置以及耦合到衬底的可打开和可再封闭的盖。 该盖可操作以选择性地阻止对样品位置的访问。 盖子包括一个连接到基片的固定端，一个相对的自由端，和一个延伸穿过样品位置的中间部分。 中间部分可释放地和可重新闭合地粘附到基底上。
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公开(公告)号：US4713250A
公开(公告)日：1987-12-15
申请号：US872125
申请日：1986-06-09
CPC分类号： A23K50/40 , A23K10/14 , Y10S426/805
摘要： Disclosed is a process for preparing a composition which improves the palatability of dog foods. According to the process, a staged enzyme reaction is employed to first digest either a proteinaceous or an amylaceous substrate. The reaction product of the first stage is emulsified with fat, and the resulting emulsion is reacted with lipase and protease, under conditions effective to provide a material which, when applied to a dog food, significantly enhances its palatability. A preferred farinaceous substrate, to be acted upon by an amylase enzyme for the first stage reaction, is corn. Preferred proteinaceous substrates, to be acted upon by protease enzyme, for the first stage reaction include soy, whey, chicken skins, and cheese solids. The resulting product is produced rapidly, contains large quantities of free fatty acids, and has a high level of palatability.
摘要翻译： 公开了一种制备改善狗食的适口性的组合物的方法。 根据该方法，使用分阶段的酶反应来首先消化蛋白质或淀粉底物。 将第一阶段的反应产物与脂肪乳化，并且所得乳液在有效提供当施用于狗食时显着增强其适口性的物质的条件下与脂肪酶和蛋白酶反应。 用于第一阶段反应的用淀粉酶作用的优选的谷物底物是玉米。 用于第一阶段反应的由蛋白酶酶作用的优选的蛋白质底物包括大豆，乳清，鸡皮和干酪固体。 所得产品快速生产，含有大量的游离脂肪酸，具有高水平的适口性。
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公开(公告)号：US06413395B1
公开(公告)日：2002-07-02
申请号：US09465870
申请日：1999-12-16
IPC分类号： G01N27327
CPC分类号： G01N27/3271 , B01L3/5027
摘要： According to an aspect of the invention a biosensor apparatus is provided, comprising a base, electrodes positioned on the base, a cover including ports, a plate positioned on the base and including apertures in communication with at least one of the electrodes, a cover including ports in communication with the plate and offset from the apertures, and at least one reagent positioned between the plate and the cover. According to a preferred embodiment the plate includes microstructures extending into the ports of the cover.
摘要翻译： 根据本发明的一个方面，提供了一种生物传感器装置，其包括基座，位于基座上的电极，包括端口的盖，位于基座上的板，并且包括与至少一个电极连通的孔，盖包括 与板连通并与孔偏移的端口以及位于板和盖之间的至少一个试剂。 根据优选实施例，板包括延伸到盖的端口中的微结构。
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