-
公开(公告)号：US06489359B2
公开(公告)日：2002-12-03
申请号：US10050076
申请日：2001-10-23
IPC分类号： A61K31155
CPC分类号： C07C305/24
摘要： The present invention relates to new sulphoxybenzamides of general formula I, processes for preparing them as well as their use as medicaments.
-
12.发明授权Benzylamine and phenylethylamine derivatives, processes for preparing the same and their use as medicaments 有权苄胺和苯乙胺衍生物，其制备方法及其作为药物的用途公开(公告)号：US06288277B1
公开(公告)日：2001-09-11
申请号：US09423160
申请日：2000-04-03
申请人： Ralf Anderskewitz , Kurt Schromm , Ernst-Otto Renth , Franz Birke , Hans Michael Jennewein , Christopher John Montague Meade
发明人： Ralf Anderskewitz , Kurt Schromm , Ernst-Otto Renth , Franz Birke , Hans Michael Jennewein , Christopher John Montague Meade
IPC分类号： C07C21100
CPC分类号： C07D295/192 , C07C217/58 , C07C217/60 , C07C271/16 , C07C317/22 , C07C323/20 , C07C2601/04
摘要： The present invention relates to new phenylamine derivatives, processes for preparing them and their use as pharmaceutical compositions. The phenylamines according to the invention correspond to the general formula I
摘要翻译： 本发明涉及新的苯胺衍生物，其制备方法及其作为药物组合物的用途。 根据本发明的苯胺对应于通式I
-
13.发明授权Benzamidine derivatives and the use thereof as medicaments with LTB4-antagonistic effect 有权苄脒衍生物及其作为具有LTB4拮抗作用的药物的用途公开(公告)号：US06197824B1
公开(公告)日：2001-03-06
申请号：US09242389
申请日：2000-06-02
申请人： Kurt Schromm , Ralf Anderskewitz , Ernst-Otto Renth , Franz Birke , Hans Michael Jennewein , Christopher John Montague Meade
发明人： Kurt Schromm , Ralf Anderskewitz , Ernst-Otto Renth , Franz Birke , Hans Michael Jennewein , Christopher John Montague Meade
IPC分类号： A61K31155
CPC分类号： C07D295/088 , C07C257/18 , C07C271/64
摘要： Novel benzamidines, having LTB4-antagonistic activity, of the formula methods for their preparation, their and their use as medicaments.
摘要翻译： 具有LTB4拮抗活性的新型苯甲脒，其制备方法及其作为药物的用途。
-
14.发明授权Benzamidine derivatives and the use thereof as medicaments with LTB4-antagonistic effect 有权苄脒衍生物及其作为具有LTB4拮抗作用的药物的用途公开(公告)号：US06265612B1
公开(公告)日：2001-07-24
申请号：US09728856
申请日：2000-12-01
申请人： Kurt Schromm , Ralf Anderskewitz , Ernst-Otto Renth , Franz Birke , Hans Michael Jennewein , Christopher John Montague Meade
发明人： Kurt Schromm , Ralf Anderskewitz , Ernst-Otto Renth , Franz Birke , Hans Michael Jennewein , Christopher John Montague Meade
IPC分类号： C07C25718
CPC分类号： C07D295/088 , C07C257/18 , C07C271/64
摘要： The present invention relates to new benzamidine derivatives, processes for preparing them and their use in pharmaceutical compositions. The new benzamidine derivatives correspond to general formula 1
摘要翻译： 本发明涉及新的苄脒衍生物，其制备方法及其在药物组合物中的用途。 新的苯甲脒衍生物对应于通式1
-
公开(公告)号：US06861547B2
公开(公告)日：2005-03-01
申请号：US10138955
申请日：2002-05-05
申请人： Joerg Brandenburg , Rolf Schmid , Rainer Soyka , Ralf Anderskewitz , Rolf Bauer , Rainer Hamm , Jutta Kroeber
发明人： Joerg Brandenburg , Rolf Schmid , Rainer Soyka , Ralf Anderskewitz , Rolf Bauer , Rainer Hamm , Jutta Kroeber
IPC分类号： C07C255/54 , C07C269/00 , C07C271/00 , C07C271/20 , C07C271/64 , C07C309/00
CPC分类号： C07C271/20 , C07C255/54 , C07C269/00 , C07C271/00 , C07C271/64
摘要： The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I) wherein: R1 denotes a group selected from among methyl, ethyl, propyl, cyclopentyl, cyclohexyl, phenyl, benzyl and —C(Me2)phenyl, each of which is optionally mono-, di- or trisubstituted by hydroxy; and, R2 denotes a group selected from among methyl, ethyl, propyl and benzyl.
摘要翻译： 本发明涉及适用于大规模工业用途的制备通式（I）化合物的方法，其中：R 1表示选自甲基，乙基，丙基，环戊基，环己基，苯基，苄基和-C （Me 2）苯基，其各自任选被羟基单，二或三取代; 并且R 2表示选自甲基，乙基，丙基和苄基的基团。
-
公开(公告)号：US06417382B1
公开(公告)日：2002-07-09
申请号：US09757253
申请日：2001-01-09
申请人： Joerg Brandenburg , Rolf Schmid , Rainer Soyka , Ralf Anderskewitz , Rolf Bauer , Rainer Hamm , Jutta Kroeber
发明人： Joerg Brandenburg , Rolf Schmid , Rainer Soyka , Ralf Anderskewitz , Rolf Bauer , Rainer Hamm , Jutta Kroeber
IPC分类号： C07C30900
摘要： The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I) wherein: R1 denotes a group selected from among methyl, ethyl, propyl, cyclopentyl, cyclohexyl, phenyl, benzyl and —C(Me2)phenyl, each of which is optionally mono-, di- or trisubstituted by hydroxy; and, R2 denotes a group selected from among methyl, ethyl, propyl and benzyl.
-
公开(公告)号：US08759386B2
公开(公告)日：2014-06-24
申请号：US13353621
申请日：2012-01-19
IPC分类号： A61K31/4155 , C07D231/10 , C07D403/12 , C07D405/12 , C07D409/12
CPC分类号： C07D403/12 , C07D405/12 , C07D409/12
摘要： Pyrazole compounds of formula (Ia) or (Ib) and pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, n and R3 have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical formulations containing the compounds and to pharmaceutical formulations containing the compounds in combination with one or more active substances.
摘要翻译： 式（Ia）或（Ib）的吡唑化合物及其药学上可接受的盐，其中Ra，Rb，Rc，Rd，Y1，Y2，Y3，Y4，Y5，Z，R1，R2，n和R3具有以下含义之一 如说明书和权利要求书中所指出的，它们作为药物的用途，含有该化合物的药物制剂和含有与一种或多种活性物质组合的化合物的药物制剂。
-
公开(公告)号：US07723381B2
公开(公告)日：2010-05-25
申请号：US11409482
申请日：2006-04-21
申请人： Ralf Anderskewitz , Horst Dollinger , Rolf Goeggel , Birgit Jung , Joerg Kley , Juergen Mack , Peter Nickolaus , Rainer Walter
发明人： Ralf Anderskewitz , Horst Dollinger , Rolf Goeggel , Birgit Jung , Joerg Kley , Juergen Mack , Peter Nickolaus , Rainer Walter
IPC分类号： A61K31/343 , C07D307/78
CPC分类号： C07D209/34 , C07D307/83 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
摘要翻译： 适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛炎症性疾病的式1化合物及其异构体及其药理学上可接受的盐，对映异构体，外消旋体，水合物或溶剂化物 的外周或中枢神经系统或癌症，以及含有这些化合物的药物组合物。
-
公开(公告)号：US07214703B2
公开(公告)日：2007-05-08
申请号：US10771756
申请日：2004-02-04
申请人： Ralf Anderskewitz , Horst Dollinger , Claudia Heine , Pascale Arielle Jane-Josee Pouzet , Thierry Bouyssou , Franz Birke
发明人： Ralf Anderskewitz , Horst Dollinger , Claudia Heine , Pascale Arielle Jane-Josee Pouzet , Thierry Bouyssou , Franz Birke
IPC分类号： A01N43/38 , A61K31/40 , C07D487/02
CPC分类号： C07D487/04 , C07D491/14 , C07D495/14
摘要： Disclosed are compounds of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar1, Ar2, A, R1, R2, R3, E1, E2, X and n are as defined in the description and claims, which are effective modulators of chemokine activity.
摘要翻译： 公开了式（I）的化合物或其立体异构体或其药学上可接受的盐，其中Ar 1，Ar 2，A，R 1， >，R 2，R 3，E 1，E 2，X和n如 描述和权利要求，其是趋化因子活性的有效调节剂。
-
20.发明申请Cyanothiophenes, their preparation and their use in pharmaceutical compositions 审中-公开氰噻吩，它们的制备及其在药物组合物中的应用公开(公告)号：US20060094764A1
公开(公告)日：2006-05-04
申请号：US11250018
申请日：2005-10-13
申请人： Ralf Anderskewitz , Gerd Morschhaeuser , Ruediger Streicher , Thomas Trieselmann , Rainer Walter
发明人： Ralf Anderskewitz , Gerd Morschhaeuser , Ruediger Streicher , Thomas Trieselmann , Rainer Walter
IPC分类号： A61K31/4436 , A61K31/381 , C07D333/38 , C07D409/02
CPC分类号： C07D333/38 , C07D409/12
摘要： The present invention relates to cyanothiophenes of general formula wherein the Rs are defined as in the claims, the tautomers, their stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly a glugacon receptor-antagonistic activity.
摘要翻译： 本发明涉及通式的氰基噻吩，其中Rs如权利要求中所定义，互变异构体，其立体异构体，其混合物及其盐具有有价值的药理学性质，特别是glugacon受体拮抗活性。
-
-
-
-
-
-
-
-
-
搜索结果
50 条记录 (耗时 0.027 秒)
