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公开(公告)号：US07553413B2
公开(公告)日：2009-06-30
申请号：US11342982
申请日：2006-01-30
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator of this invention having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator has agitator blades extending outwardly from the lower end. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. The concentrator has a top with an upper opening through which the upper end of the actuator stem extends, and a lower opening in which the filter is positioned. The concentrator chamber can have a cylindrical inner wall, and the agitator blades can have an outer edge in close proximity to the inner wall with the space between the outer edge and the inner wall being less than the diameter of the gel beads. The filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. The method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. The plasma is introduced into a concentration chamber containing a plurality of dehydrated concentrator gel beads and an agitator. Then water is removed from the plasma while stirring the beads to reduce plasma polarization and breaking up clumps of beads that form during the agitation. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.
摘要翻译： 本发明的等离子体浓缩器具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器。 搅拌器具有从下端向外延伸的搅拌器叶片。 搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。 集中器具有顶部，其具有上部开口，致动器杆的上端延伸穿过该上部开口，以及下部开口，过滤器定位在该开口中。 浓缩器室可以具有圆柱形内壁，并且搅拌器叶片可以具有紧邻内壁的外边缘，外边缘和内壁之间的空间小于凝胶珠的直径。 选择过滤器以在环境重力条件下阻止等离子体的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。 该方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。 将等离子体引入含有多个脱水浓缩器凝胶珠和搅拌器的浓缩室中。 然后在搅拌珠子的同时从等离子体中除去水，以减少等离子极化并破坏在搅拌过程中形成的珠粒团块。 然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。
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公开(公告)号：US08596470B2
公开(公告)日：2013-12-03
申请号：US13400188
申请日：2012-02-20
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator system operable to use centrifugation to fractionate a multiple component material, such as a suspension including blood, comprises a buoy. The buoy can be carried in a separation container and has a tuned density that is configured to reach an equilibrium position in the multiple component material. A guide surface is carried on a buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
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13.发明申请公开(公告)号：US20120145652A1
公开(公告)日：2012-06-14
申请号：US13400188
申请日：2012-02-20
IPC分类号： B01D43/00
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator system operable to use centrifugation to fractionate a multiple component material, such as a suspension including blood, comprises a buoy. The buoy can be carried in a separation container and has a tuned density that is configured to reach an equilibrium position in the multiple component material. A guide surface is carried on a buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译： 可操作以使用离心分离多组分材料（例如包括血液的悬浮液）的分离器系统包括浮标。 浮标可以携带在分离容器中，并且具有被配置为在多组分材料中达到平衡位置的调节密度。 引导表面承载在浮标上表面上并且倾斜于靠近浮标周界的堆积位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。
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14.发明授权公开(公告)号：US08119013B2
公开(公告)日：2012-02-21
申请号：US12897401
申请日：2010-10-04
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译： 使用离心分离悬浮液如血液的分离器包括分离容器和浮标。 浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。 引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。 浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。
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15.发明授权Apparatus and method for preparing platelet rich plasma and concentrates thereof 有权制备富血小板血浆及其浓缩物的装置及方法公开(公告)号：US07866485B2
公开(公告)日：2011-01-11
申请号：US11831605
申请日：2007-07-31
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B01D33/067 , B01D35/00 , B01D24/32 , B04B3/00
CPC分类号： A61M1/3496 , A61M1/3482 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , B04B5/0442 , B04B2005/0478
摘要： A Platelet Rich Plasma separator assembly is disclosed. The assembly can include a cylindrical outer wall closed at the top by an upper plate and closed at the bottom. A bottom plate having an upper surface sloped down to a central opening. The top edge of the inner wall terminates at a distance from the upper plate to define an annular erythrocyte passageway therebetween. The inner wall has an outer surface and an inner surface that slopes radially inward from its top edge to its bottom at an angle of from 0.2 to 5 degrees with a central axis of the inner wall. A cylindrical depth filter is positioned between the inner surface of the outer wall and the outer surface of the inner wall in communication with the inner wall through the erythrocyte passageway.
摘要翻译： 公开了一种富血小板血浆分离器组件。 组件可以包括在顶部由上板封闭并在底部封闭的圆柱形外壁。 底板，其具有向下倾斜到中心开口的上表面。 内壁的顶边缘终止于距上板一定距离处，以在其间限定环形红细胞通道。 内壁具有外表面和内表面，内表面与内壁的中心轴线以从0.2到5度的角度从其顶部边缘到其底部向内径向倾斜。 圆柱形深度过滤器位于外壁的内表面和内壁的外表面之间，通过红细胞通道与内壁连通。
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16.发明授权Method and apparatus for preparing platelet rich plasma and concentrates thereof 有权制备富血小板血浆及其浓缩物的方法和装置公开(公告)号：US07708152B2
公开(公告)日：2010-05-04
申请号：US11342761
申请日：2006-01-30
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译： 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏 。
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公开(公告)号：US08105495B2
公开(公告)日：2012-01-31
申请号：US12987605
申请日：2011-01-10
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
CPC分类号： A61M1/3496 , A61M1/3482 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , B04B5/0442 , B04B2005/0478
摘要： A process for separating platelet rich plasma from a blood sample using a platelet rich plasma separator system is disclosed. The system includes an inner wall having a top edge and a central axis that is surrounded by a depth filter having a capacity to receive all of the erythrocytes in the blood sample, where an inner surface of the inner wall has an angle of about 0.2° from the central axis of the inner wall. The process includes spinning the inner cylinder at its central axis at a speed that separates the erythrocytes from plasma and platelets and causes the erythrocytes to collect against an inner surface of the depth filter. The cylinder is continually spun for a sufficient time to allow substantially all of the erythrocytes to flow up the inner surface and over the top edge into the depth filter, leaving platelet enriched plasma (PRP) in the inner cylinder, such that upon discontinuing the spinning, permits the platelet enriched plasma to flow to the bottom of the inner cylinder.
摘要翻译： 公开了一种使用富血小板血浆分离器系统从血液样品中分离富血小板血浆的方法。 该系统包括具有顶部边缘和中心轴线的内壁，该内壁被深度过滤器包围，该深度过滤器具有容纳血液样本中的所有红细胞的能力，其中内壁的内表面具有约0.2°的角度 从内壁的中心轴线。 该方法包括以将红细胞与血浆和血小板分离的速度在其中心轴处旋转内筒，并使红细胞收集在深度过滤器的内表面上。 气瓶连续旋转足够的时间，以使基本上所有的红细胞都能从内表面上升到顶部边缘上方进入深度过滤器，从而在内筒中留下富含血小板的血浆（PRP），从而在停止纺丝时 允许富含血小板的血浆流到内筒的底部。
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公开(公告)号：US20110284460A1
公开(公告)日：2011-11-24
申请号：US13198038
申请日：2011-08-04
IPC分类号： B01D21/00
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , A61M2202/0427 , B01L3/50215 , B01L2200/026
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
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19.发明申请Method and Apparatus for Preparing Platelet Rich Plasma and Concentrates Thereof 失效制备富血小板血浆及其浓缩物的方法和装置公开(公告)号：US20110281714A1
公开(公告)日：2011-11-17
申请号：US13193849
申请日：2011-07-29
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B04B7/18
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译： 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏 。
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公开(公告)号：US20110100919A1
公开(公告)日：2011-05-05
申请号：US12987605
申请日：2011-01-10
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
CPC分类号： A61M1/3496 , A61M1/3482 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , B04B5/0442 , B04B2005/0478
摘要： A process for separating platelet rich plasma from a blood sample using a platelet rich plasma separator system is disclosed. The system includes an inner wall having a top edge and a central axis that is surrounded by a depth filter having a capacity to receive all of the erythrocytes in the blood sample, where an inner surface of the inner wall has an angle of about 0.2° from the central axis of the inner wall. The process includes spinning the inner cylinder at its central axis at a speed that separates the erythrocytes from plasma and platelets and causes the erythrocytes to collect against an inner surface of the depth filter. The cylinder is continually spun for a sufficient time to allow substantially all of the erythrocytes to flow up the inner surface and over the top edge into the depth filter, leaving platelet enriched plasma (PRP) in the inner cylinder, such that upon discontinuing the spinning, permits the platelet enriched plasma to flow to the bottom of the inner cylinder.
摘要翻译： 公开了一种使用富血小板血浆分离器系统从血液样品中分离富血小板血浆的方法。 该系统包括具有顶部边缘和中心轴线的内壁，该内壁被深度过滤器包围，该深度过滤器具有容纳血液样本中的所有红细胞的能力，其中内壁的内表面具有约0.2°的角度 从内壁的中心轴线。 该方法包括以将红细胞与血浆和血小板分离的速度在其中心轴处旋转内筒，并使红细胞收集在深度过滤器的内表面上。 气瓶连续旋转足够的时间，以使得基本上所有的红细胞都能从内表面和顶部边缘上方流入深度过滤器，从而使血小板富集等离子体（PRP）留在内筒中，从而在停止纺丝时 允许富含血小板的血浆流到内筒的底部。
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